The noninvasive sampling of dermal interstitial fluid (ISF) for the monitoring of clinical biomarkers is a greatly appealing area of research. The identification of molecular biomarkers in biological fluids has been accelerated with -omics analyses but remains limited in ISF because of its time-consuming and complex extraction process. Here, the generation of microneedle (MN) patches made of superabsorbent acrylate-based hydrogels for the rapid sampling of dermal ISF is described to explore its proteome. In depth, iterative optimization allows the identification of novel acrylate-based compositions with the required chemical, mechanical, and biocompatibility properties allowing proteomic analysis of the extracted ISF for the first time after sampling with swelling MNs. The generated MN arrays show no cytotoxic effect, successfully cross the stratum corneum, and can collect up to 6 µL of dermal ISF in 10 min in vivo. Proteomics lead to the detection of 176 clinically relevant biomarkers in the collected samples validating the use of ISF as a relevant bodily fluid for disease monitoring and diagnostic. Importantly, it is discovered that extraction fingerprint is strongly dependent on the MNs chemistry, and thus specific biomarkers could be selectively extracted by tuning the composition of the patch, making the system versatile and specific. 相似文献
Quantum Information Processing - In this note, I attempt to explore the quantum Colonel Blotto game and contrast it with the classical Colonel Blotto game; in particular, I will focus on an... 相似文献
Some form of mechanochemical experience has existed from fine grinding of materials since prehistoric times, yet the first systematic investigations on the chemical effects of mechanical action were carried out only at the end of the nineteenth century. Walthére Spring studied the consolidation and reactions of powdered materials due to high pressure at the University of Liège, in order to understand the formation of minerals in the earth’s crust and M. Carey Lea carried out experiments on the decomposition of compounds by grinding in a mortar. In some of his experiments mechanical action produced distinctly different result from the effect of heat. The first part of this paper compares the circumstances and results of Spring and Lea. The other important period in the history of mechanochemistry was the 1960s, the time when the first dedicated conferences were organized and a broader community of mechanochemists formed. This happened in the Soviet Union and Eastern Europe where several groups were working on subjects related to mechanochemistry. In 1968, the first dedicated conference was organized as a special session of the yearly meeting of Soviet colloid chemists. An attempt is made to reconstruct the circumstances leading to that event and the roles played by Rebinder and Thiessen in bringing it together. The next conference on mechanochemistry was already a separate event and it started a yearly series. Extensions have led to the INCOME conferences, including this one in Ko?ice in 2017. 相似文献
Our goal is the determination of the material flow processes around the mixing screws and introducing a new mixing index which can characterize the perform 相似文献
One dimensional (1D) nanostructures attract considerable attention, enabling a broad application owing to their unique properties. However, the precise mechanism of 1D morphology attainment remains a matter of debate. In this study, ultrafast picosecond (ps) laser-induced treatment on upconversion nanoparticles (UCNPs) is offered as a tool for 1D-nanostructures formation. Fragmentation, reshaping through recrystallization process and bioadaptation of initially hydrophobic (β-Na1.5Y1.5F6: Yb3+, Tm3+/β-Na1.5Y1.5F6) core/shell nanoparticles by means of one-step laser treatment in water are demonstrated. “True” 1D nanostructures through “Medusa”-like structures can be obtained, maintaining anti-Stokes luminescence functionalities. A matter of the one-dimensional UCNPs based on direction of energy migration processes is debated. The proposed laser treatment approach is suitable for fast UCNP surface modification and nano-to-nano transformation, that open unique opportunities to expand UCNP applications in industry and biomedicine.
Quantum Information Processing - Historically, the information efficiency of the secret key in quantum key distribution (QKD) schemes based on binary signal formats was limited to 1 bit/particle.... 相似文献
Microalgae-based biorefineries for the production of renewable biofuels like biodiesel, upgraded bio-oil, biochar, biogas and other high-value chemicals have received great attention in recent decades as potential major sources of energy for the future. Microalgae are a suitable species to produce biodiesel and other high energy density by-products; however, it is questionable whether a net energy gain can be realized or not considering the whole processing chain. In the present study, the energy balances of different algae-based biofuel and bioenergy production technologies are investigated in detail and compared to each other corresponding to a cradle-to-grave overall energetic analysis. The study includes cultivation, harvesting, cell pretreatments (cell disruption, drying, grinding), lipid extraction, transesterification, gasification and hydrothermal liquefaction with bio-oil stabilization and hydroprocessing. The energy consumption and energy gain are estimated for each operational step to determine the net energy ratio (NER, energy output over energy input) for the overall technologies studied. Our detailed investigation enables to detect the most energy consuming unit operation, that is, the bottleneck point(s) of the microalgae-based technologies which should be still improved in the future for the sake of more efficient algae-based biorefineries. The investigation makes also possible to evaluate and compare the different large scale alternatives for biomass transformation. Positive energy balances with a NER value of 1.109 and 1.137 are found in two already existing processes: open raceway ponds and closed photobioreactors, respectively. Our work gives also a detailed algorithm that can be followed at the evaluation of other microalgae-based biorefineries. 相似文献
While severe plastic deformation (SPD) on bulk samples has been widely applied for modifying the H-sorption properties, there has been little attention towards the use of SPD on powder materials. In this context, the aim of the present work was to compare the H-storage properties of high-pressure torsion (HPT) consolidated products obtained from two distinct Mg powder precursors: atomized micro-sized and condensed ultrafine powder particles. The results showed that the nature of the initial powder precursor had a pronounced effect on the H-sorption behavior. The HPT product obtained from the condensed ultrafine powder showed faster absorption kinetics than the consolidated product obtained from the atomized powder. However, the HPT product obtained from atomized powder could absorb more hydrogen and showed faster desorption kinetics corresponding to a lower activation energy. These results are discussed by taking into account the effectiveness of the HPT process to refine the grain sizes and differences in the dispersion of fine MgO oxide particles. 相似文献