Reduced‐scale test to assess the effect of fire barriers on the flaming combustion of cored composites: An upholstery‐material case study

Herein, we describe a reduced‐scale test (“Cube” test), measuring the fire performance of specimens including a fire barrier (FB) and a flammable core material, which acts as the main fuel load. The specimen is intended to reproduce a cross‐section of a composite product where heat/mass transfer occurs primarily in a direction perpendicular to the FB. The Cube test procedure and benefits are discussed in this work by adopting residential upholstery furniture as an exemplary study. One flexible polyurethane foam, one polypropylene cover fabric, and 10 commercially available FBs were selected. They were used to compare the fire performance of FBs, measured in terms of peak of heat release rate, in the ASTM E1474‐14 standard test and the newly developed Cube test. Edge effects severely affected the performance of FBs in the ASTM E1474‐14 standard test but not in the Cube test. Furthermore, appropriate test conditions were determined in the Cube test to measure the so‐called “wetting point,” that is, the time and value of heat release rate measured when flammable liquid products were first observed on the bottom of the specimen. The relevance of the “wetting point” in terms of full‐scale fire performance and failure mechanism of FBs is discussed.     

Genetically Encoded Libraries of Constrained Peptides

Many therapeutic peptides can still be improved with respect to target specificity, target affinity, resistance to peptidases/proteases, physical stability, and capacity to pass through membranes required for oral delivery. Several modifications can improve the peptides’ properties, in particular those that impose (a) conformational constraint(s). Screening of constrained peptides and the identification of hits is greatly facilitated by the generation of genetically encoded libraries. Recent breakthrough bacterial, phage, and yeast display screening systems of ribosomally synthesized post-translationally constrained peptides, particularly those of lanthipeptides, are earning special attention. Here we provide an overview of display systems for constrained, genetically encoded peptides and indicate prospects of constrained peptide-displaying phage and bacterial systems as such in vivo.     

Thermal Expansion of Alkaline‐Doped Lanthanum Ferrite Near the Néel Temperature

The thermal expansion and magnetic behaviors of divalent, alkaline‐doped lanthanum ferrites (La_0.9M_0.1FeO₃, M=Ca, Sr, Ba) were assessed using a combination of dilatometry, magnetometry, time‐of‐flight neutron diffraction, and high‐temperature X‐ray diffraction. Néel temperatures were determined through vibrating sample magnetometry and correlated well with changes in thermal expansion behavior observed during both dilatometry and X‐ray diffraction. The Néel temperatures observed for pure, Ca‐doped, Sr‐doped, and Ba‐doped lanthanum ferrites were 471°C, 351°C, 465°C, and 466°C, respectively. The effect of divalent substitutions on the magnetic behavior are attributed to charge compensation mechanisms and structural changes in the material.     

夏普 对应“迅驰”的平板电脑登场

2003年1月9日,英特尔(Intel)发表了全新的无线上网技术--迅驰。迅驰技术的发布,使我们的网络生活开始改变,随时随地、无拘无束的上网冲浪成为了今后发展的一个重点。目前开始在市场上应用迅驰技术的产品有笔记本电脑和平板电脑(Tablet PC)两种,本质上两种产品基本上相同。相比传统笔记本电脑,平板电脑时尚的色彩更浓厚一些。记得3月份的时候,宏基推出了全球首款基于迅驰技术的平板电脑,推出后的反响十分强烈。     

Unrelated toxin–antitoxin systems cooperate to induce persistence

Persisters are drug-tolerant bacteria that account for the majority of bacterial infections. They are not mutants, rather, they are slow-growing cells in an otherwise normally growing population. It is known that the frequency of persisters in a population is correlated with the number of toxin–antitoxin systems in the organism. Our previous work provided a mechanistic link between the two by showing how multiple toxin–antitoxin systems, which are present in nearly all bacteria, can cooperate to induce bistable toxin concentrations that result in a heterogeneous population of slow- and fast-growing cells. As such, the slow-growing persisters are a bet-hedging subpopulation maintained under normal conditions. For technical reasons, the model assumed that the kinetic parameters of the various toxin–antitoxin systems in the cell are identical, but experimental data indicate that they differ, sometimes dramatically. Thus, a critical question remains: whether toxin–antitoxin systems from the diverse families, often found together in a cell, with significantly different kinetics, can cooperate in a similar manner. Here, we characterize the interaction of toxin–antitoxin systems from many families that are unrelated and kinetically diverse, and identify the essential determinant for their cooperation. The generic architecture of toxin–antitoxin systems provides the potential for bistability, and our results show that even when they do not exhibit bistability alone, unrelated systems can be coupled by the growth rate to create a strongly bistable, hysteretic switch between normal (fast-growing) and persistent (slow-growing) states. Different combinations of kinetic parameters can produce similar toxic switching thresholds, and the proximity of the thresholds is the primary determinant of bistability. Stochastic fluctuations can spontaneously switch all of the toxin–antitoxin systems in a cell at once. The spontaneous switch creates a heterogeneous population of growing and non-growing cells, typical of persisters, that exist under normal conditions, rather than only as an induced response. The frequency of persisters in the population can be tuned for a particular environmental niche by mixing and matching unrelated systems via mutation, horizontal gene transfer and selection.     

Plant health and food security,linking science,economics, policy and industry

Protecting plant resources from harmful organisms that can spread internationally is a major challenge for plant protection organisations. Natural scientists and economists have methods that contribute to informing and supporting government decision makers in plant health authorities, who also need to account for stakeholders’ views when developing policy and regulations to mitigate plant pest risks. Increasingly plant protection authorities seek to develop integrated decision making through economists and scientists working within an interdisciplinary framework. In this special section of Food Security we introduce a series of papers presented at an international conference that brought together natural scientists, economists, industry representatives and plant health policy makers to report the state of the art and explore the direction and future research needs for such interdisciplinary working to deliver rational plant protection policy and improved food security for the 21st Century. The collection of papers combine contributions from leading academics and influential policy makers and provides cohesive international perspectives on the use of science and economics, as well as their integration, to progress the development of integrated multi-disciplinary plant health policy making around the world. Using a modified version of the world café method during a conference workshop activity, participants identified greater international co-operation as a key mechanism that would reduce international plant health risks. Specifically, co-operation over analysis among stakeholders and along supply chains were seen as key issues.     

Anticipatory routing of police helicopters

We have developed a decision support application for the Dutch Aviation Police and Air Support unit for routing their helicopters in anticipation of unknown future incidents. These incidents are not known in advance, yet do require a swift response. A response might include the dispatch of a police helicopter to support the police on the ground. If a helicopter takes too long to arrive at the crime scene, it might be too late to assist. Hence, helicopters have to be proximate when an incident happens to increase the likelihood of being able to support the police on the ground in apprehending suspects. We propose the use of a forecasting technique, followed by a routing heuristic to maximize the number of incidents where a helicopter provides a successful assist. We have implemented these techniques in a decision support application in collaboration with the Dutch Aviation Police and Air Support. Using numerical experiments, we show that our application has the potential to improve the success rate with a factor nine. The Dutch Air Support and Aviation Police are now using the application.     

Preparation and Certification of Hydrogen in Titanium Alloy Standard Reference Materials

A series of three hydrogen in titanium alloy Standard Reference Materials (SRMs 2452, 2453, and 2454) was prepared with hydrogen mass fractions bracketing the hydrogen specification limit of 125?mg/kg. Commercial titanium alloy Ti6Al4V (6?pct aluminum and 4?pct vanadium) was heated under vacuum in a furnace to remove native hydrogen, then it was doped with a measured quantity of hydrogen. Prompt gamma-ray activation analysis was used to determine hydrogen in the degassed material and finished SRMs. A combination of preparation data and PGAA measurement was used to certify the hydrogen mass fraction of each. The certified hydrogen mass fractions are 62.5?mg/kg?±?1.6?mg/kg for SRM 2452, 114?mg/kg?±?5?mg/kg for SRM 2453, and 211?mg/kg?±?4?mg/kg for SRM 2454.     

ASTM国际标准组织信息ASTM获取证书项目

ASTM国际标准组织最近发布了第一项关于获取证书项目的国际标准ASTM E2659-获取证书项目的标准规程.此项标准由E36认证认可技术委员会负责.E36技术委员会成立于1973年,负责制定有关合格评定的技术标准.E2659由E36.30个人认证分技术委员会制定,旨在为颁发证书机构(大学、政府机构、用人单位、培训机构和行业协会)开发和管理优质认证项目提供标准指南,从而帮助相关利益方评定认证项目的质量.