全文获取类型
收费全文 | 30668篇 |
免费 | 1485篇 |
国内免费 | 108篇 |
专业分类
电工技术 | 379篇 |
综合类 | 230篇 |
化学工业 | 5591篇 |
金属工艺 | 630篇 |
机械仪表 | 617篇 |
建筑科学 | 1097篇 |
矿业工程 | 97篇 |
能源动力 | 996篇 |
轻工业 | 4762篇 |
水利工程 | 261篇 |
石油天然气 | 169篇 |
武器工业 | 6篇 |
无线电 | 2345篇 |
一般工业技术 | 4441篇 |
冶金工业 | 6321篇 |
原子能技术 | 239篇 |
自动化技术 | 4080篇 |
出版年
2023年 | 163篇 |
2022年 | 237篇 |
2021年 | 871篇 |
2020年 | 615篇 |
2019年 | 682篇 |
2018年 | 803篇 |
2017年 | 873篇 |
2016年 | 851篇 |
2015年 | 653篇 |
2014年 | 993篇 |
2013年 | 1673篇 |
2012年 | 1480篇 |
2011年 | 1844篇 |
2010年 | 1320篇 |
2009年 | 1393篇 |
2008年 | 1263篇 |
2007年 | 1139篇 |
2006年 | 899篇 |
2005年 | 928篇 |
2004年 | 995篇 |
2003年 | 876篇 |
2002年 | 832篇 |
2001年 | 698篇 |
2000年 | 519篇 |
1999年 | 526篇 |
1998年 | 2021篇 |
1997年 | 1327篇 |
1996年 | 925篇 |
1995年 | 617篇 |
1994年 | 486篇 |
1993年 | 545篇 |
1992年 | 232篇 |
1991年 | 285篇 |
1990年 | 234篇 |
1989年 | 203篇 |
1988年 | 214篇 |
1987年 | 161篇 |
1986年 | 170篇 |
1985年 | 179篇 |
1984年 | 133篇 |
1983年 | 91篇 |
1982年 | 120篇 |
1981年 | 128篇 |
1980年 | 118篇 |
1979年 | 94篇 |
1978年 | 75篇 |
1977年 | 138篇 |
1976年 | 225篇 |
1975年 | 81篇 |
1973年 | 49篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Dr. Aline D. de Araujo Huy T. Nguyen Prof. David P. Fairlie 《Chembiochem : a European journal of chemical biology》2021,22(10):1784-1789
The conventional S-alkylation of cysteine relies upon using activated electrophiles. Here we demonstrate high-yielding and selective S-alkylation and S-lipidation of cysteines in unprotected synthetic peptides and proteins by using weak electrophiles and a Zn2+ promoter. Linear or branched iodoalkanes can S-alkylate cysteine in an unprotected 38-residue Myc peptide fragment and in a 91-residue miniprotein Omomyc, thus highlighting selective late-stage synthetic modifications. Metal-assisted cysteine alkylation is also effective for incorporating dehydroalanine into unprotected peptides and for peptide cyclisation via aliphatic thioether crosslinks, including customising macrocycles to stabilise helical peptides for enhanced uptake and delivery to proteins inside cells. Chemoselective and efficient late-stage Zn2+-promoted cysteine alkylation in unprotected peptides and proteins promises many useful applications. 相似文献
2.
Dr. Roser Borràs-Tudurí Dr. Anna Alcaide Dr. Sandrine Aspeslag Dr. Lorena Usero Dr. Carmen Serra Dr. Carme Roura-Mir Dr. Dirk Elewaut Dr. Amadeu Llebaria 《ChemMedChem》2021,16(16):2491-2496
Natural Killer T (NKT) cells play an important role in the immune response and can be activated by glycolipids presented by CD1d protein. We present MCS-0208, an unprecedented arylthioether-phytoceramide able to induce potent invariant NKT (iNKT) cell activation, notably when tested in human iNKT cells. This arylsphingolipid analog has a simple phenyl group containing a single hydroxyl substituent as a surrogate of the sugar ring. The phenylthioether structure contrasts with α-galactosylceramide ( 1 ), the prototypical glycolipid used to induce iNKT cell stimulation, where the galactose 2’-OH and 3’-OH substituents are accepted as the minimal footprint and considered critical for NKT T cell receptor (TCR) recognition. A computational study supports the recognition of aromatic compound by the CD1d and TCR proteins as radically new structures for NKT cell stimulation. 相似文献
3.
da Silva Edson Santos de Mello Prado Renato Soares Anelisa de Aquino Vidal Lacerda de Almeida Hilario Junior dos Santos Durvalina Maria M. 《SILICON》2021,13(3):813-818
Silicon - Corn plants are highly demanding of nitrogen and the application of silicon has been studied because it minimizes stress from different natures, and for the better utilization of some... 相似文献
4.
Aguayo-Canela Francisco José Alaiz-Moretón Héctor García-Ordás María Teresa Benítez-Andrades José Alberto Benavides Carmen García-Rodríguez Isaías 《The Journal of supercomputing》2021,77(11):13046-13068
The Journal of Supercomputing - The increasing number of connected devices and the complexity of Internet of Things (IoT) ecosystems are demanding new architectures for managing and securing these... 相似文献
5.
Gabriela Pitolli Lyra Valdemir Santos Eliria Maria de Jesus Agnolon Pallone Ruth Herta Goldschmidt Aliaga Kiminami Bruno Carlos De Santis João Adriano Rossignolo 《International Journal of Applied Ceramic Technology》2021,18(3):705-715
This work aimed to examine the performance of the hybrid sintering of clay ceramic in a microwave furnace, compared to the sintering process in a conventional furnace. The raw materials were subjected to X-ray fluorescence, loss on ignition (LOI), X-ray diffraction, particle size distribution, real specific mass, and thermogravimetric analyses. The red clay ceramic mass was prepared, extruded, pre-sintered in a conventional furnace at 600°C/60 min, and sintered at temperatures between 700 °C and 1100 °C. The sintering conventional (resistive oven) was carried out for 60 min with a heating rate of 10°C/min. In the microwave furnace, the sintering times were 5, 10, and 15 min, with a heating rate of 50°C/min, with a sintering chamber coated with silicon carbide (susceptor). The sintered specimens were characterized according to linear shrinkage, water absorption, apparent porosity, apparent specific mass, X-ray diffraction, Raman spectroscopy analysis, spectroscopy analysis in the ultraviolet and visible regions, microhardness, and scanning electron microscopy. The results showed that microwave sintering promoted an increase in the microhardness and apparent specific mass, and reduction in water absorption and apparent porosity values, due to greater densification in the microstructure. The best results occurred for specimens sintered at 1100°C. 相似文献
6.
Luisa Barbieri Alessandro Bigi Fernanda Andreola Isabella Lancelotti Grazia Ghermandi Maria Teresa Cotes Palomino Carmen Martínez García 《International Journal of Applied Ceramic Technology》2021,18(2):353-368
Within a circular economy approach, this study investigates the environmental impact of lightweight aggregates (LWAs) produced starting from different mixes of different clays with brewery sludge and cattle bone flour ash (CBA), used as poring and fertilizing agents, respectively. The environmental impact was evaluated by means of release tests, insulation capacity, carbon footprint (CFP), and particulate matter emission during pellet firing. Release tests representative of LWAs realistic application showed very high release of phosphate and satisfactory release of potassium. The thermal insulation of the LWAs was tested by thermal imaging camera and resulted highly variable depending on the composition, with the mix containing CBA performing best. This latter composition leads also to the smallest CO2 equivalent emission, due to the calorific power of CBA, allowing lower consumption of fossil fuels during the LWA production. Finally, total particulate emissions during the thermal treatment resulted similar in terms of mass for all mixes, while differences in terms of particle morphology and composition occurred. Samples containing residue resulted with a quite good release behavior, CFP, and insulation properties, but higher emission of particles, particularly when glass is added. 相似文献
7.
Lucía Beltrn-Camacho Marta Rojas-Torres M
Carmen Durn-Ruiz 《International journal of molecular sciences》2021,22(5)
Critical limb ischemia (CLI) constitutes the most severe form of peripheral arterial disease (PAD), it is characterized by progressive blockade of arterial vessels, commonly correlated to atherosclerosis. Currently, revascularization strategies (bypass grafting, angioplasty) remain the first option for CLI patients, although less than 45% of them are eligible for surgical intervention mainly due to associated comorbidities. Moreover, patients usually require amputation in the short-term. Angiogenic cell therapy has arisen as a promising alternative for these “no-option” patients, with many studies demonstrating the potential of stem cells to enhance revascularization by promoting vessel formation and blood flow recovery in ischemic tissues. Herein, we provide an overview of studies focused on the use of angiogenic cell therapies in CLI in the last years, from approaches testing different cell types in animal/pre-clinical models of CLI, to the clinical trials currently under evaluation. Furthermore, recent alternatives related to stem cell therapies such as the use of secretomes, exosomes, or even microRNA, will be also described. 相似文献
8.
9.
Carmen J. Pastor-Maldonado Juan M. Surez-Rivero Suleva Povea-Cabello Mnica lvarez-Crdoba Irene Villaln-García Manuel Munuera-Cabeza Alejandra Surez-Carrillo Marta Talavern-Rey Jos A. Snchez-Alczar 《International journal of molecular sciences》2020,21(22)
The aim of this review is to shed light over the most recent advances in Coenzyme Q10 (CoQ10) applications as well as to provide detailed information about the functions of this versatile molecule, which have proven to be of great interest in the medical field. Traditionally, CoQ10 clinical use was based on its antioxidant properties; however, a wide range of highly interesting alternative functions have recently been discovered. In this line, CoQ10 has shown pain-alleviating properties in fibromyalgia patients, a membrane-stabilizing function, immune system enhancing ability, or a fundamental role for insulin sensitivity, apart from potentially beneficial properties for familial hypercholesterolemia patients. In brief, it shows a remarkable amount of functions in addition to those yet to be discovered. Despite its multiple therapeutic applications, CoQ10 is not commonly prescribed as a drug because of its low oral bioavailability, which compromises its efficacy. Hence, several formulations have been developed to face such inconvenience. These were initially designed as lipid nanoparticles for CoQ10 encapsulation and distribution through biological membranes and eventually evolved towards chemical modifications of the molecule to decrease its hydrophobicity. Some of the most promising formulations will also be discussed in this review. 相似文献
10.