全文获取类型
收费全文 | 1048篇 |
免费 | 50篇 |
专业分类
电工技术 | 15篇 |
综合类 | 6篇 |
化学工业 | 254篇 |
金属工艺 | 13篇 |
机械仪表 | 52篇 |
建筑科学 | 34篇 |
矿业工程 | 1篇 |
能源动力 | 50篇 |
轻工业 | 128篇 |
水利工程 | 7篇 |
石油天然气 | 1篇 |
无线电 | 56篇 |
一般工业技术 | 154篇 |
冶金工业 | 51篇 |
原子能技术 | 15篇 |
自动化技术 | 261篇 |
出版年
2023年 | 10篇 |
2022年 | 9篇 |
2021年 | 57篇 |
2020年 | 33篇 |
2019年 | 34篇 |
2018年 | 27篇 |
2017年 | 30篇 |
2016年 | 54篇 |
2015年 | 24篇 |
2014年 | 44篇 |
2013年 | 96篇 |
2012年 | 82篇 |
2011年 | 67篇 |
2010年 | 57篇 |
2009年 | 57篇 |
2008年 | 50篇 |
2007年 | 51篇 |
2006年 | 37篇 |
2005年 | 40篇 |
2004年 | 26篇 |
2003年 | 35篇 |
2002年 | 24篇 |
2001年 | 16篇 |
2000年 | 13篇 |
1999年 | 12篇 |
1998年 | 9篇 |
1997年 | 17篇 |
1996年 | 9篇 |
1995年 | 8篇 |
1994年 | 9篇 |
1993年 | 7篇 |
1992年 | 3篇 |
1991年 | 3篇 |
1990年 | 3篇 |
1989年 | 5篇 |
1987年 | 2篇 |
1986年 | 3篇 |
1985年 | 2篇 |
1984年 | 4篇 |
1983年 | 3篇 |
1982年 | 7篇 |
1981年 | 3篇 |
1980年 | 2篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1973年 | 3篇 |
1972年 | 1篇 |
1971年 | 1篇 |
1968年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有1098条查询结果,搜索用时 31 毫秒
1.
Domenico Maiorano Jana El Etri Camille Franchet Jean-Sbastien Hoffmann 《International journal of molecular sciences》2021,22(8)
DNA can experience “replication stress”, an important source of genome instability, induced by various external or endogenous impediments that slow down or stall DNA synthesis. While genome instability is largely documented to favor both tumor formation and heterogeneity, as well as drug resistance, conversely, excessive instability appears to suppress tumorigenesis and is associated with improved prognosis. These findings support the view that karyotypic diversity, necessary to adapt to selective pressures, may be limited in tumors so as to reduce the risk of excessive instability. This review aims to highlight the contribution of specialized DNA polymerases in limiting extreme genetic instability by allowing DNA replication to occur even in the presence of DNA damage, to either avoid broken forks or favor their repair after collapse. These mechanisms and their key regulators Rad18 and Polθ not only offer diversity and evolutionary advantage by increasing mutagenic events, but also provide cancer cells with a way to escape anti-cancer therapies that target replication forks. 相似文献
2.
3.
Valentina Somano Domenico Ferrero Massimo Santarelli Davide Papurello 《International Journal of Hydrogen Energy》2021,46(33):17421-17434
The coupling between biomass gasification and Solid Oxide Fuel Cells can represent a sustainable and efficient system for electricity production. This work aims to develop a preliminary model for the operation of a tubular, electrolyte-supported fuel cell (SOFC) fed by a syngas mixture. The fuel required by the SOFC system is produced inside the energy generator box from an integrated biomass gasification system. This study stems from the European DB-SOFC project, that proposed the exploitation of the abundant biomasses deriving from agricultural residues for energetic purposes (as from olive oil and wine production). In this study, the main processes have been simulated to find a possible configuration to obtain a power value of 200 W. 25 cells were used in the model to produce the required power. The results showed that at 0.7 V it is possible to achieve 12.3 W, when the biomass gasification was integrated into the SOFC box, while it was possible to achieve 9.6 W when the system was fed by externally produced syngas. 相似文献
4.
Alessandra Di Paola Giuseppe Palumbo Pietro Merli Maura Argenziano Chiara Tortora Luisa Strocchio Domenico Roberti Claudia Santoro Silverio Perrotta Francesca Rossi 《International journal of molecular sciences》2021,22(1)
Immune Thrombocytopenia (ITP) is an autoimmune disease characterized by autoantibodies-mediated platelet destruction, a prevalence of M1 pro-inflammatory macrophage phenotype and an elevated T helper 1 and T helper 2 lymphocytes (Th1/Th2) ratio, resulting in impairment of inflammatory profile and immune response. Macrophages are immune cells, present as pro-inflammatory classically activated macrophages (M1) or as anti-inflammatory alternatively activated macrophages (M2). They have a key role in ITP, acting both as effector cells, phagocytizing platelets, and, as antigen presenting cells, stimulating auto-antibodies against platelets production. Eltrombopag (ELT) is a thrombopoietin receptor agonist licensed for chronic ITP to stimulate platelet production. Moreover, it improves T and B regulatory cells functions, suppresses T-cells activity, and inhibits monocytes activation. We analyzed the effect of ELT on macrophage phenotype polarization, proposing a new possible mechanism of action. We suggest it as a mediator of macrophage phenotype switch from the M1 pro-inflammatory type to the M2 anti-inflammatory one in paediatric patients with ITP, in order to reduce inflammatory state and restore the immune system function. Our results provide new insights into the therapy and the management of ITP, suggesting ELT also as immune-modulating drug. 相似文献
5.
Nicola Alessio Domenico Aprile Salvatore Cappabianca Gianfranco Peluso Giovanni Di Bernardo Umberto Galderisi 《International journal of molecular sciences》2021,22(6)
During their life span, cells have two possible states: a non-cycling, quiescent state (G0) and a cycling, activated state. Cells may enter a reversible G0 state of quiescence or, alternatively, they may undergo an irreversible G0 state. The latter may be a physiological differentiation or, following a stress event, a senescent status. Discrimination among the several G0 states represents a significant investigation, since quiescence, differentiation, and senescence are progressive phenomena with intermediate transitional stages. We used the expression of Ki67, RPS6, and beta-galactosidase to identify healthy cells that progressively enter and leave quiescence through G0-entry, G0 and G0-alert states. We then evaluated how cells may enter senescence following a genotoxic stressful event. We identified an initial stress stage with the expression of beta-galactosidase and Ki67 proliferation marker. Cells may recover from stress events or become senescent passing through early and late senescence states. Discrimination between quiescence and senescence was based on the expression of RPS6, a marker of active protein synthesis that is present in senescent cells but absent in quiescent cells. Even taking into account that fixed G0 states do not exist, our molecular algorithm may represent a method for identifying turning points of G0 transitional states that continuously change. 相似文献
6.
Bruni Vittoria Tartaglione Michela Vitulano Domenico 《Multimedia Tools and Applications》2022,81(16):22653-22676
Multimedia Tools and Applications - This paper presents a method for Photo Response Non Uniformity (PRNU) pattern noise based camera identification. It takes advantage of the coherence between... 相似文献
7.
Key hurdles in the Mediterranean‐style dry fermented sausage “Salsiccia Sarda” as influenced by different ingredients related to product safety 下载免费PDF全文
Riccardo Consigliere Domenico Meloni Rina Mazzette 《Journal of Food Processing and Preservation》2018,42(1)
According to EC Reg. 2073/2005, Food Business Operators must demonstrate the safety of fermented sausages by using different approaches based on physico‐chemical analyses, predictive microbiology and Microbial Challenge Test. The aim of the present study was to investigate the application of different ingredients related to product safety on the development of key hurdles in Mediterranean‐style dry fermented sausages as “Salsiccia Sarda”. Weight loss, pH and aw were evaluated as ripening monitoring tool. Predictive mathematical models to evaluate the survival of Listeria monocytogenes complemented the present study. The evolution of aw and weight loss to values capable to support product's safety was shown to be closely related and was validated as a simple and effective monitoring tool of the Critical Control Point ripening. Based on the fermented sausage characteristics, “Salsiccia Sarda” at the end of ripening is unable to support the growth of the pathogen.
Practical applications
The correlation between weight loss and aw was validated as a simple and effective monitoring tool of the CCP ripening. The inclusion of a flavour stabilizer based on hydrolyzed pork proteins showed some effects on the aw evolution: the use of this additive can bring benefits in terms of assuring a constant safety of the final products and addressing the needs of reducing the cost of production. The empirical application of the hurdle technology in the production of “Salsiccia Sarda” highlights the need for Food Business Operators (FBOs) to carefully evaluate the physico‐chemical properties of the products and to control the ripening stage more effectively ensuring the production of fermented sausages with aw and pH values than can support product's safety. 相似文献8.
Dr. Jessica Ceramella Dr. Annaluisa Mariconda Dr. Camillo Rosano Dr. Domenico Iacopetta Dr. Anna Caruso Prof. Pasquale Longo Prof. Maria Stefania Sinicropi Prof. Carmela Saturnino 《ChemMedChem》2020,15(23):2306-2316
Cancer is going to be the first cause of mortality worldwide in the 21th century. It is considered a multifactorial disease that results from the combined influence of many genetic aberrations, leading to abnormal cell proliferation. As microtubules are strongly implicated in cellular growth, they represent an important target for cancer treatment. The well-known microtubule-targeting agents (MTAs) including paclitaxel, colchicine and vinca alkaloids are commonly used in the treatment of various cancers. However, adverse effects and drug resistance are major limitations in their clinical use. To find new candidates able to induce microtubule alteration with reduced toxic effects or drug resistance, we studied a small new series of derivatives that present imidazolinic, guanidinic, thioureidic and hydrazinic groups ( 1 – 9 ). All the compounds were tested for their antitumor activity against a panel of six tumoral cell models. In particular, compound 8 (nonane-1,9-diyl-bis-S-amidinothiourea dihydrobromide) showed the lowest IC50 value against HeLa cells, together with a low cytotoxicity for normal cells. This compound was able to induce the apoptotic mitochondrial pathway and inhibited tubulin polymerization with a similar efficacy to vinblastine and nocodazole. Taken together, these promising biological properties make compound 8 useful for the development of novel therapeutic approaches in cancer treatment. 相似文献
9.
Dr. Rosaria Ciriminna Dr. Alexandra Fidalgo Dr. Francesco Meneguzzo Dr. Alessandro Presentato Dr. Antonino Scurria Dr. Domenico Nuzzo Prof. Rosa Alduina Prof. Laura M. Ilharco Dr. Mario Pagliaro 《ChemMedChem》2020,15(23):2228-2235
First reported in the late 1930s and partly explained in 1970, the antibacterial activity of pectin remained almost ignored until the late 1990s. The concomitant emergence of research on natural antibacterials and new usages of pectin polysaccharides, including those in medicine widely researched in Russia, has led to a renaissance of research into the physiological properties of this uniquely versatile polysaccharide ubiquitous in plants and fruits. By collecting scattered information, this study provides an updated overview of the subtle factors affecting the behaviour of pectin as an antimicrobial. Less-degraded pectin extracted by acid-free routes, we argue in the conclusions, will soon find applications from new treatments for polymicrobial infections to use as an implantable biomaterial in tissue and bone engineering. 相似文献
10.
Alberto Castellini Manuele Bicego Domenico Bloisi Jason Blum Francesco Masillo Sergio Peignier 《控制论与系统》2019,50(8):658-671
AbstractIn this paper, we propose the use of subspace clustering to detect the states of dynamical systems from sequences of observations. In particular, we generate sparse and interpretable models that relate the states of aquatic drones involved in autonomous water monitoring to the properties (e.g., statistical distribution) of data collected by drone sensors. The subspace clustering algorithm used is called SubCMedians. A quantitative experimental analysis is performed to investigate the connections between i) learning parameters and performance, ii) noise in the data and performance. The clustering obtained with this analysis outperforms those generated by previous approaches. 相似文献