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1.
Dr. Omer K. Rasheed Cassandra Buhl Dr. Jay T. Evans Dr. Kendal T. Ryter 《ChemMedChem》2021,16(8):1246-1251
Mincle agonists have been shown to induce inflammatory cytokine production, such as tumor necrosis factor-alpha (TNF) and promote the development of a Th1/Th17 immune response that might be crucial to development of effective vaccination against pathogens such as Mycobacterium tuberculosis. As an expansion of our previous work, a library of 6,6′-amide and sulfonamide α,α-d -trehalose compounds with various substituents on the aromatic ring was synthesized efficiently in good to excellent yields. These compounds were evaluated for their ability to activate the human C-type lectin receptor Mincle by the induction of cytokines from human peripheral blood mononuclear cells. A preliminary structure–activity relationship (SAR) of these novel trehalose diamides and sulfonamides revealed that aryl amide-linked trehalose compounds demonstrated improved activity and relatively high potency cytokine production compared to the Mincle ligand trehalose dibehenate adjuvant (TDB) and the natural ligand trehalose dimycolate (TDM) inducing dose-dependent and human-Mincle-specific stimulation in a HEK reporter cell line. 相似文献
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M. Anjana K. Rajmohana P.N. Buhl K.M. Shameem 《The International journal of environmental studies》2016,73(2):186-195
Platygaster luteipes Buhl (Hymenoptera: Platygastridae) is reported for the first time from India. Several specimens of both sexes of the species were reared from the globular galls on mature leaves of black pepper. The hitherto undescribed male of the species is characterized and illustrated. 相似文献
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Composite materials with vibrations damping qualities can be made of two steel sheets enclosing a viscoelastic plasticcorelayer. These sandwich sheets often need to be formed. Material parameters are determined to describe the forming process. Based on these parameters, pilot studies are carried out in order to develop recommendations for forming this class of material. 相似文献
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Tench R. Delavaux J.-M. Tzeng L. Smith R. Buhl L. Alferness R. 《Lightwave Technology, Journal of》1987,5(4):492-501
This article describes the fabrication and performance evaluation ofX -cut andZ -cut Ti:LiNbO3 traveling wave waveguide phase modulators designed for coherent systems applications at 1.3 and 1.5 μm. Details of device fabrication and measurements of phase shift as a function of optical wavelength, input polarization, modulation voltage, and modulation frequency are reported. Phase modulator performance in a 40-Mbit/s self-heterodyne coherent DPSK experiment is also discussed. 相似文献