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排序方式: 共有382条查询结果,搜索用时 390 毫秒
1.
Abidur Rahman Makoto Kobayashi Kotaro Sugimoto Yuta Endo Manabu Kojima Shigenori Furukawa Takafumi Watanabe Shu Soeda Yuko Hashimoto Keiya Fujimori Hideki Chiba 《International journal of molecular sciences》2021,22(7)
Background: Within the claudin (CLDN) family, CLDN12 mRNA expression is altered in various types of cancer, but its clinicopathological relevance has yet to be established due to the absence of specific antibodies (Abs) with broad applications. Methods: We generated a monoclonal Ab (mAb) against human/mouse CLDN12 and verified its specificity. By performing immunohistochemical staining and semiquantification, we evaluated the relationship between CLDN12 expression and clinicopathological parameters in tissues from 138 cases of cervical cancer. Results: Western blot and immunohistochemical analyses revealed that the established mAb selectively recognized the CLDN12 protein. Twenty six of the 138 cases (18.8%) showed low CLDN12 expression, and the disease-specific survival (DSS) and recurrence-free survival rates were significantly decreased compared with those in the high CLDN12 expression group. We also demonstrated, via univariable and multivariable analyses, that the low CLDN12 expression represents a significant prognostic factor for the DSS of cervical cancer patients (HR 3.412, p = 0.002 and HR 2.615, p = 0.029, respectively). Conclusions: It can be concluded that a reduced CLDN12 expression predicts a poor outcome for cervical cancer. The novel anti-CLDN12 mAb could be a valuable tool to evaluate the biological relevance of the CLDN12 expression in diverse cancer types and other diseases. 相似文献
2.
A highly transparent and thermally stable copolymer of 1‐adamantyl methacrylate and styrene 下载免费PDF全文
Thermal and optical properties of copolymers of 1‐adamantyl methacrylate (AdMA) and styrene (St) prepared by free radical polymerization in the bulk are investigated. The copolymer forms an azeotrope when the composition is AdMA/St = 55/45 mol%. The glass transition temperature and decomposition temperature of the azeotropic copolymer are 170 and ca 340 °C, respectively. The refractive index increases nonlinearly with St content from 1.522 to 1.591. The light scattering loss at 633 nm is 28.1 dB km?1, which is less than half of that of polystyrene. The total optical loss including molecular vibrational absorption, which is evaluated using a copolymer‐based optical fiber, is 292–645 dB km?1 at 500–700 nm. These values correspond to transmittances of 86–93% for a 1 m optical path length. © 2014 Society of Chemical Industry 相似文献
3.
Kotaro Take-uchi Takashi E-naka Norimitsu Kon-no Yozo Hosotani Takashi Orimoto Masanori Iwase 《国际钢铁研究》1997,68(12):516-519
By employing an electrochemical technique involving stabilized zirconia as solid electrolyte and Mo + MoO2 mixture as reference electrode, the equilibrium oxygen partial pressures for three-phase assemblages of CaSiO3(s) + Ca3Si2O7(s) + {CaO + SiO2 + FexO} melt and Ca3Si2O7(s) + Ca2SiO4(s) + {CaO + SiO2 + FexO} melt were determined as: - log {PO2 (CS + C3S2 + L)/bar} = - 3.22 13000/(T/K) ± 0.05 - log {PO2 (C3S2 + C2S + L)/bar} = - 0.92 16400/ (T/K) ± 0.04. respectively, where CS, C3S2 and C2S indicate CaSiO3(s), Ca3Si2O7(s). and Ca2SiO4(s), respectively. 相似文献
4.
Critical heat fluxes (CHFs) were measured for two types of rectangular ducts containing horizontal flat plate heaters. One has the flat plate heater of 6 mm wide and 20 mm long located on the inner lower wall at 50 mm from the inlet. The other duct has two horizontal flat plates of 6 mm wide and 20 mm long on inner upper and lower walls at 50 mm from the inlet. The equation of CHF for the forced convection containing a new nondimensional-parameter m introduced in order to calculate cross-sectionally averaged liquid temperature at the center of the duct was derived based on two fluid model, ordinary convection theorem and experimental results. It was confirmed that this correlation can describe not only the author's data on the duct but also other worker's data for channels with different shapes and sizes. 相似文献
5.
Kotaro Matsuuchi Tadashi Fukami Nobuyuki Naoe Ryoichi Hanaoka Shinzo Takata Toshio Miyamoto 《Electrical Engineering in Japan》2005,150(2):43-49
This paper presents a method of predicting the steady‐state performance of a new hybrid‐excitation synchronous machine (HESM) theoretically. The field pole of this HESM is axially divided into two parts; one is an excitation part and the other a permanent‐magnet (PM) part. A nonlinear equivalent circuit, which can include the saliency of the rotor and the magnetic saturation due to the iron core, is derived. Based on this equivalent circuit, the steady‐state performance of the HESM is calculated, and the results are confirmed through experiments. © 2004 Wiley Periodicals, Inc. Electr Eng Jpn, 150(2): 43–49, 2005; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/eej.20033 相似文献
6.
M Tanaka T Hakuto M Akatsuka E Morimoto T Hama M Morimoto Y Hiraga M Hyodo 《Canadian Metallurgical Quarterly》1993,42(6):883-887
We injected botulinum toxin to treat hemifacial spasm, and investigated the effects and the patient's impression of this treatment. Average duration of improvement lasted about 3.5 months in both the initial treatment group and the recurrent group. However the patients in the recurrent group received fewer units of botulinum toxin than those in the initial treatment group. Except for local paralysis that disappeared within a month, there were very few complications. Most patient were satisfied with this treatment. We conclude that the treatment of hemifacial spasm with botulinum toxin is both simple and useful. 相似文献
7.
F Deák á Horváth á Kiss Z Seres A Galonsky CK Gelbke H Hama L Heilbronn D Krofcheck WG Lynch DW Sackett HR Schelin MB Tsang J Kasagi T Murakami 《Canadian Metallurgical Quarterly》1995,52(1):219-227
An extruding wire knife was used to give adult male CFHB rats a minimally traumatic unilateral mechanical lesion of the medial forebrain bundle. In addition, some rats received bilateral intrastriatal injections of one of three fluorescent retrograde tracers either eight days before or eight days after the lesion. Injections made after the lesion revealed that about half of the animals had complete lesions of the nigrostriatal tract, while the other half were incompletely lesioned, the mean proportion of non-axotomized neurons being 23%. Over the 10 weeks following the lesions, the number of tyrosine hydroxylase-immunoreactive cells in the lesioned substantia nigra fell linearly, reaching a mean of 29% of that of the control substantia nigra. In the animals which were completely lesioned, neuronal survival at 10 weeks varied between 6 and 12%. That the disappearance of tyrosine hydroxylase-immunoreactive neurons was due to cell death rather than the loss of tyrosine hydroxylase itself was confirmed by labelling the cells with Fluoro Gold before axotomy; the tracer was seen in survival neurons, microglia and in a few involuted neurons which continued to be tyrosine hydroxylase-immunoreactive. This percentage of neurons surviving axotomy corresponds to the proportion of substantia nigra neurons which project to the contralateral striatum, and these neurons were in the region of the substantia nigra from which the contralateral projection originated. It is concluded that following mechanical transection of the nigrostriatal tract, all truly axotomized substantia nigra neurons die over a period of about 10 weeks. 相似文献
8.
Yasushi Nagato Seiji Higashitani Kotaro Yamada Katsuhiko Nagai 《Journal of Low Temperature Physics》1996,103(1-2):1-22
We present a Green's function theory of the rough surface effects on the anisotropic BCS states using the formulation developed in the randomly rippled wall model. It is shown that the randomly rippled wall formulation is general enough to treat rough surface effects from the specular limit to the diffusive limit. We propose a statistical wall configuration such that gives the diffusive limit in the normal state. Within the weak coupling theory, we give a formal solution of the quasi-classical Green's function in a slab geometry and in a semi-infinite geometry with arbitrarily rough surfaces. The formal solution already satisfies the boundary condition. In the diffusive limit, the present theory correctly recovers the linearized gap equation obtained by Kjäldman et al. for the p-wave state in a slab geometry. 相似文献
9.
Details of the vorticity field structure associated with the 3D Tollmien-Schlichting waves have been examined based upon the
recent numerical studies of the subject. First, a single obliquet-s wave has been found to have the velocity component parallel to the wave front playing an overall dominant role, in particular,
to create the longitudinal vorticity. The so-called Benney-Lin longitudinal vortices are then demonstrated to be, in fact,
a minor consequence compared with the localized longitudinal vorticity field and its periodic pumping. Finally, the formation
of the longitudinal vorticity field in the fundamental- and subharmonic-mode interactions is explained.
The research reported in this paper has been supported in part by Bundesministerium für Forschung und Technologie and by Deutsche
Forschungsgemeinschaft. The major part of the paper has been presented at the Third Asian Congress of Fluid Mechanics, 1–5
September 1986, in Tokyo, as a General Lecture by the senior author, FRH. 相似文献
10.
Microsystem Technologies - TEMPO-oxidized cellulose nanofiber (TOCN) has been drawing much attention as a useful material for preparation of transparent and stiff films or substrates. In this work,... 相似文献