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排序方式: 共有138条查询结果,搜索用时 156 毫秒
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Bushman Brad J.; Bonacci Angelicca M.; van Dijk Mirjam; Baumeister Roy F. 《Canadian Metallurgical Quarterly》2003,84(5):1027
Laboratory analog studies investigated the theory that narcissism and reactance contribute to causing rape. In Study 1, narcissism correlated positively with rape-supportive beliefs and negatively with empathy for rape victims. In Study 2, narcissists reported more enjoyment than other men of film depictions that presented consensual, affectionate activity followed by rape (but not in response to either affection or rape alone). In Study 3, narcissists were more punitive than other men toward a female confederate who refused to read a sexually arousing passage aloud to them. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Matti Schneider Felix Ospald Matthias Kabel 《International journal for numerical methods in engineering》2016,105(9):693-720
In this article, we propose to discretize the problem of linear elastic homogenization by finite differences on a staggered grid and introduce fast and robust solvers. Our method shares some properties with the FFT‐based homogenization technique of Moulinec and Suquet, which has received widespread attention recently because of its robustness and computational speed. These similarities include the use of FFT and the resulting performing solvers. The staggered grid discretization, however, offers three crucial improvements. Firstly, solutions obtained by our method are completely devoid of the spurious oscillations characterizing solutions obtained by Moulinec–Suquet's discretization. Secondly, the iteration numbers of our solvers are bounded independently of the grid size and the contrast. In particular, our solvers converge for three‐dimensional porous structures, which cannot be handled by Moulinec–Suquet's method. Thirdly, the finite difference discretization allows for algorithmic variants with lower memory consumption. More precisely, it is possible to reduce the memory consumption of the Moulinec–Suquet algorithms by 50%. We underline the effectiveness and the applicability of our methods by several numerical experiments of industrial scale. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
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Wilfried M. Post Mirjam A. A. Huis in ’t Veld Sylvia A. A. van den Boogaard 《Personal and Ubiquitous Computing》2008,12(3):223-235
Many attempts are underway for developing meeting support tools, but less attention is paid to the evaluation of meetingware.
This article describes the development and testing of an instrument for evaluating meeting tools. First, we specified the
object of evaluation—meetings—by means of a set of input, process, and outcome factors. Then, we designed the process of evaluation,
consisting of, first, the generation of meeting behavior in the form of a controlled series of meetings within the context
of a project and, second, the measurement of the identified meeting factors. To measure these factors, a rating scale, questionnaires,
and information flow analysis were used. Next, the instrument was tested, and the factors for successful meetings were determined
in 13 projects in which four participants had to meet four times. The evaluation instrument proved to be a reliable and useful
aid for the development and improvement of meeting tools. 相似文献
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4‐Biphenylalanine‐ and 3‐Phenyltyrosine‐Derived Hydroxamic Acids as Inhibitors of the JumonjiC‐Domain‐Containing Histone Demethylase KDM4A 下载免费PDF全文
Dr. Ludovica Morera Dr. Martin Roatsch Michael C. D. Fürst Dr. Inga Hoffmann Dr. Johanna Senger Mirjam Hau Dr. Henriette Franz Prof. Dr. Roland Schüle Prof. Dr. Markus R. Heinrich Prof. Dr. Manfred Jung 《ChemMedChem》2016,11(18):2063-2083
Overexpression of the histone lysine demethylase KDM4A, which regulates H3K9 and H3K36 methylation states, has been related to the pathology of several human cancers. We found that a previously reported hydroxamate‐based histone deacetylase (HDAC) inhibitor (SW55) was also able to weakly inhibit this demethylase with an IC50 value of 25.4 μm . Herein we report the synthesis and biochemical evaluations, with two orthogonal in vitro assays, of a series of derivatives of this lead structure. With extensive chemical modifications on the lead structure, also by exploiting the versatility of the radical arylation with aryldiazonium salts, we were able to increase the potency of the derivatives against KDM4A to the low‐micromolar range and, more importantly, to obtain demethylase selectivity with respect to HDACs. Cell‐permeable derivatives clearly showed a demethylase‐inhibition‐dependent antiproliferative effect against HL‐60 human promyelocytic leukemia cells. 相似文献
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Mirjam Theelen Vincent Hans Nicolas Barreau Henk Steijvers Zeger Vroon Miro Zeman 《Progress in Photovoltaics: Research and Applications》2015,23(5):537-545
Unencapsulated CIGS solar cells with high and low contents of sodium (Na) and potassium (K) were simultaneously exposed to damp heat and illumination. The solar cells with a high alkali (Na, K) content exhibited higher initial conversion efficiencies, but degraded severely within 100 h, while the alkali poor samples kept relatively stable performance under damp heat and illumination. The degradation of the samples with a high alkali content resulted in the formation of sodium rich spots on the top ZnO:Al surface of the samples. This is likely caused by light‐induced Na+ migration via the grain boundaries in the absorber to the depletion region, where the Na+ accumulated. This allowed subsequent Na+ transport through the depletion region due to the lowering of the internal electric field caused both by the Na+ accumulation and illumination. The migration resulted in the formation of shunt paths, which reduced the shunt resistance and open circuit voltage. Furthermore, ingression of water into the ZnO:Al is expected to be responsible for a slow but steady increase in series resistance for both high and low alkali solar cells. Additionally, sodium migration led to a severe increase of the series resistance in case of alkali rich samples. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
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