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1.
Fault tree analysis is commonly used to assess the reliability of potentially hazardous industrial systems. The type of logic is usually restricted to AND and OR gates, which makes the fault tree structure coherent. In non‐coherent structures not only components' failures but also components' working states contribute to the failure of the system. The qualitative and quantitative analyses of such fault trees can present additional difficulties when compared with the coherent versions. It is shown that the binary decision diagram (BDD) method can overcome some of the difficulties in the analysis of non‐coherent fault trees. This paper presents the conversion process of non‐coherent fault trees to BDDs. A fault tree is converted to a BDD that represents the system structure function (SFBDD). An SFBDD can then be used to quantify the system failure parameters but is not suitable for the qualitative analysis. Established methods, such as the meta‐products BDD method, the zero‐suppressed BDD (ZBDD) method and the labelled BDD (L‐BDD) method, require an additional BDD that contains all prime implicant sets. The process using some of the methods can be time consuming and is not very efficient. In addition, in real‐time applications the conversion process is less important and the requirement is to provide an efficient analysis. Recent uses of the BDD method are for real‐time system prognosis. In such situations as events happen, or failures occur, the prediction of mission success is updated and used in the decision‐making process. Both qualitative and quantitative assessments are required for the decision making. Under these conditions fast processing and small storage requirements are essential. Fast processing is a feature of the BDD method. It would be advantageous if a single BDD structure could be used for both the qualitative and quantitative analyses. Therefore, a new method, the ternary decision diagram (TDD) method, is presented in this paper, where a fault tree is converted to a TDD that allows both qualitative and quantitative analyses and no additional BDDs are required. The efficiency of the four methods is compared using an example fault tree library. Copyright © 2008 John Wiley & Sons, Ltd.  相似文献   
2.
Experimental study of temperature‐ and frequency‐dependent properties of the commercially available shape memory polymer Tecoflex? EG 72D (TFX) (Lubrizol, USA) using dynamic mechanical analysis (DMA) technique is presented. Temperature scan DMA tests have been carried out in three distinct deformation modes, uniaxial tension, three‐point bending, and simple torsion, using two different testing rigs at different test parameters (frequency, strain amplitude, and heating rate) in temperatures ranging from below to above the glass transition temperature. The influence of different test parameters and some discrepancies in the temperature‐dependent storage and loss moduli (and hence the loss factor) measured by DMA in different deformation modes are discussed.  相似文献   
3.
Gold (I)-containing compounds, including aurothioglucose (ATG), are potent in vitro inhibitors of several selenocysteine-containing enzymes. Gold compounds have also been shown to potentiate the virulence of several viruses in mice, including coxsackievirus, implicated as a possible infectious agent in Keshan disease. One possible mechanism by which gold compounds may be increasing the virulence of viral infections in mice is by acting as a selenium antagonist in vivo and inducing oxidative stress. To investigate the possible role of gold compounds in inducing oxidative stress in mice, we assessed the ability of ATG administered in vivo to inhibit the activity of the selenocysteine-containing enzymes thioredoxin reductase (TR) and glutathione peroxidase (GPX1). Doses as low as 0. 025 mg ATG/g body weight caused significant and prolonged inhibition of TR activity in all tissues examined. No such inhibition of GPX1 activity was seen, indicating differential in vivo sensitivity of the enzymes to inhibition by ATG. In liver and heart, some recovery of TR activity was observed after a 7-d period, but no recovery was observed in pancreas or kidney. Because TR is involved in several important cellular redox functions, its inhibition most likely will affect multiple cellular processes. These results indicate that in vivo administration of ATG results in significant and long-lasting inhibition of TR activity. Such inhibition of TR could lead to increased levels of oxidative stress in vivo, thereby increasing the virulence of several viruses including the coxsackievirus.  相似文献   
4.
Distinct differences in in vivo stability of the two diastereomeric C-Functionalized CyDTPA chelating agents, (CHX-A DTPA and CHX-B DTPA, both racemates), as recently reported prompted further investigation as to why differences in configuration produced striking effects on the in vivo stability of their yttrium complexes. To this end, the four individual component stereoisomers of CHX-A and CHX-B were synthesized and ability to bind yttrium was investigated both in vitro and in vivo.  相似文献   
5.
We investigated the influence of nutrition and exercise interventions within cognitive/behavioral and public health formats on weight and blood lipid profiles in obese children. Compliance was also examined as well as the relationship of the compliance measures with clinical outcome variables. Three conditions were compared over 16 sessions: nutrition and eating-habit change followed by exercise (NE), exercise followed by nutrition and eating-habit change (EN), and an information control (INFO). NE and EN were presented in a cognitive/ behavioral framework which focused on the development of self-regulation whereas the INFO condition received the same material in a public health/educational model. NE and EN participants evidenced modest, yet significant, reductions in weight and blood lipids, and the impact of these two interventions endured at a five-year follow-up. In contrast, INFO participants displayed stable weight and blood lipids during the course of the program, and most remained morbidly obese at follow-up. Improved nutrition, increased physical activity and fitness were significantly correlated with weight and lipid reductions.  相似文献   
6.
The aim of this study is to derive an asymptotic expression for the probability that an infectious disease will disappear from a population at the end of a major outbreak ('fade-out'). The study deals with a stochastic SIR-model. Local asymptotic expansions are constructed for the deterministic trajectories of the corresponding deterministic system, in particular for the deterministic trajectory starting in the saddle point. The analytical expression for the probability of extinction is derived by asymptotically solving a boundary value problem based on the Fokker-Planck equation for the stochastic system. The asymptotic results are compared with results obtained by random walk simulations.  相似文献   
7.
ULTRA was established on the 1st April 1990, to consider applications made by registered medical practitioners seeking approval to transplant an organ between 2 living unrelated persons in the United Kingdom.  相似文献   
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