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排序方式: 共有528条查询结果,搜索用时 15 毫秒
1.
Benhui Hu Christopher Berkey Timothy Feliciano Xiaohong Chen Zhuyun Li Chao Chen Shahrouz Amini Mui Hoon Nai Qun-Li Lei Ran Ni Juan Wang Wan Ru Leow Shaowu Pan Yong-Qiang Li Pingqiang Cai Ali Miserez Shuzhou Li Chwee Teck Lim Yun-Long Wu Teri W. Odom Reinhold H. Dauskardt Xiaodong Chen 《Advanced materials (Deerfield Beach, Fla.)》2020,32(12):1907030
Bacterial infections remain a leading threat to global health because of the misuse of antibiotics and the rise in drug-resistant pathogens. Although several strategies such as photothermal therapy and magneto-thermal therapy can suppress bacterial infections, excessive heat often damages host cells and lengthens the healing time. Here, a localized thermal managing strategy, thermal-disrupting interface induced mitigation (TRIM), is reported, to minimize intercellular cohesion loss for accurate antibacterial therapy. The TRIM dressing film is composed of alternative microscale arrangement of heat-responsive hydrogel regions and mechanical support regions, which enables the surface microtopography to have a significant effect on disrupting bacterial colonization upon infrared irradiation. The regulation of the interfacial contact to the attached skin confines the produced heat and minimizes the risk of skin damage during thermoablation. Quantitative mechanobiology studies demonstrate the TRIM dressing film with a critical dimension for surface features plays a critical role in maintaining intercellular cohesion of the epidermis during photothermal therapy. Finally, endowing wound dressing with the TRIM effect via in vivo studies in S. aureus infected mice demonstrates a promising strategy for mitigating the side effects of photothermal therapy against a wide spectrum of bacterial infections, promoting future biointerface design for antibacterial therapy. 相似文献
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Tania Chacón-Ordóñez Reinhold Carle Ralf Schweiggert 《Journal of the science of food and agriculture》2019,99(7):3220-3239
The frequent consumption of carotenoid-rich foods has been associated with numerous health benefits, such as the supply of provitamin A. To exert these health benefits, carotenoids need to be efficiently liberated from the food matrix, micellized in the small intestine, taken up by the enterocytes and absorbed into the human blood stream. Enormous efforts have been made to better understand these processes. Because human studies are costly, labor-intense and time-consuming, the evaluation of carotenoid liberation and micellization at the laboratory scale using simulated in vitro digestion models has proven to be an important tool for obtaining preliminary results prior to conducting human studies. In particular, the liberation from the food matrix and the intestinal micellization can be mimicked by simulated digestion, yielding an estimate of the so-called bioaccessibility of a carotenoid. In the present review, we provide an overview of the carotenoid digestion process in vivo, the currently used in vitro digestion models and the outcomes of previous bioaccessibility studies, with a special focus on correlations with concomitantly conducted human studies. Furthermore, we advocate for the on-going requirement of better standardized digestion protocols and, in addition, we provide suggestions for the complementation of the acquired knowledge and current nutritional recommendations. © 2018 Society of Chemical Industry 相似文献
6.
Melanie Holzwarth Sabine Korhummel Reinhold Carle Dietmar R. Kammerer 《European Food Research and Technology》2012,234(2):207-222
Strawberry purées were prepared using a commercial polygalacturonase (PG) and a highly purified pectinesterase (PE) preparation,
respectively. To elucidate the effect of pectin on color stability following enzymatic pulp maceration, pectin composition
was studied by isolating and fractionating the alcohol-insoluble residue from the strawberry purées. The purées were stored
at +20 and +4 °C in the dark over a period of 24 weeks monitoring the amounts of monomeric and polymeric anthocyanins as well
as antioxidant activities (FRAP, TEAC). Individual anthocyanins were analyzed by HPLC–DAD–MS
n
, and color measurements were obtained in the CIE L*a*b* system. Pectin composition was significantly modified following enzymatic maceration of the purées. While PG treatment generally
resulted in pectin losses, oxalate-soluble pectins were increased in PE-treated purées. After 24 weeks of storage, the best
anthocyanin retention was observed in PE-treated purées. Such products also revealed greatest anthocyanin half-life values
and lowest proportion of polymeric pigments. Compared to an untreated control, enzymatic purée maceration using the PG was
also beneficial for pigment retention, but less effective than PE. In contrast, color and antioxidant activity were independent
of both enzymatic treatments. An initial heating step (90 °C, 10 s) for immediate inactivation of native enzymes such as polyphenoloxidases
slightly improved pigment stability, while lowered temperature during mash maceration was less effective. However, by far
best color and pigment retention were achieved when the purées were stored at 4 °C in the dark. 相似文献
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Dr. Sven Eck Werner Ecker Thomas Wlanis Hans-Peter Gänser Reinhold Ebner 《BHM Berg- und Hüttenm?nnische Monatshefte》2014,159(9):371-374
Through process modelling of surface densified gears produced by powder metallurgy (PM) was established by coupling the modelling of the manufacturing processes surface densification, carburization, and heat treatment. The complete model allows the prediction of the local microstructure and hardness in the gear as well as the appearance and direction of residual stresses in the final part. The structural integrity of the part is governed, on the one hand, by the local material properties and residual stresses and, on the other hand, by the load stresses calculated for typical operating conditions. A simplified hardness dependent Haigh diagram was used to calculate the maximum allowable cyclic stresses for the gear tooth and to derive a local utilization ratio as target entity for optimization of the individual steps of the production chain. 相似文献
9.
Stephanie R. Dupont Fernando Novoa Eszter Voroshazi Reinhold H. Dauskardt 《Advanced functional materials》2014,24(9):1325-1332
The highly conductive polymer PEDOT:PSS is a widely used hole transport layer and transparent electrode in organic electronic devices. To date, the mechanical and fracture properties of this conductive polymer layer are not well understood. Notably, the decohesion rate of the PEDOT:PSS layer and its sensitivity to moist environments has not been reported, which is central in determining the lifetimes of organic electronic devices. Here, it is demonstrated that the decohesion rate is highly sensitive to the ambient moisture content, temperature, and mechanical stress. The kinetic mechanisms are elucidated using atomistic bond rupture models and the decohesion process is shown to be facilitated by a chemical reaction between water molecules from the environment and strained hydrogen bonds. Hydrogen bonds are the predominant bonding mechanism between individual PEDOT:PSS grains within the layer and cause a significant loss in cohesion when they are broken. Understanding the decohesion kinetics and mechanisms in these films is essential for the mechanical integrity of devices containing PEDOT:PSS layers and yields general guidelines for the design of more reliable organic electronic devices. 相似文献
10.
Conductive Transparent TiNx/TiO2 Hybrid Films Deposited on Plastics in Air Using Atmospheric Plasma Processing 下载免费PDF全文
Siming Dong Makoto Watanabe Reinhold H. Dauskardt 《Advanced functional materials》2014,24(20):3075-3081
The successful deposition of conductive transparent TiNx/TiO2 hybrid films on both polycarbonate and silicon substrates from a titanium ethoxide precursor is demonstrated in air using atmospheric plasma processing equipped with a high‐temperature precursor delivery system. The hybrid film chemical composition, deposition rates, optical and electrical properties along with the adhesion energy to the polycarbonate substrate are investigated as a function of plasma power and plasma gas composition. The film is a hybrid of amorphous and crystalline rutile titanium oxide phases and amorphous titanium nitride that depend on the processing conditions. The visible transmittance increases from 71% to 83% with decreasing plasma power and increasing nitrogen content of the plasma gas. The film resistivity is in the range of ~8.5 × 101 to 2.4 × 105 ohm cm. The adhesion energy to the polycarbonate substrate varies from ~1.2 to 8.5 J/m2 with increasing plasma power and decreasing plasma gas nitrogen content. Finally, annealing the film or introducing hydrogen to the primary plasma gas significantly affects the composition and decreases thin‐film resistivity. 相似文献