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排序方式: 共有155条查询结果,搜索用时 15 毫秒
1.
Mootaz M. Salman Zaid Al-Obaidi Philip Kitchen Andrea Loreto Roslyn M. Bill Richard Wade-Martins 《International journal of molecular sciences》2021,22(9)
Neurodegenerative diseases (NDs) including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease are incurable and affect millions of people worldwide. The development of treatments for this unmet clinical need is a major global research challenge. Computer-aided drug design (CADD) methods minimize the huge number of ligands that could be screened in biological assays, reducing the cost, time, and effort required to develop new drugs. In this review, we provide an introduction to CADD and examine the progress in applying CADD and other molecular docking studies to NDs. We provide an updated overview of potential therapeutic targets for various NDs and discuss some of the advantages and disadvantages of these tools. 相似文献
2.
Adnan Hasan Bdair Aighuraibawi Selvakumar Manickam Rosni Abdullah Zaid Abdi Alkareem Alyasseri Ayman Khallel Dilovan Asaad Zebari Hussam Mohammed Jasim Mazin Mohammed Abed Zainb Hussein Arif 《计算机系统科学与工程》2023,47(1):553-574
Internet Protocol version 6 (IPv6) is the latest version of IP that goal to host 3.4 × 1038 unique IP addresses of devices in the network. IPv6 has introduced new features like Neighbour Discovery Protocol (NDP) and Address Auto-configuration Scheme. IPv6 needed several protocols like the Address Auto-configuration Scheme and Internet Control Message Protocol (ICMPv6). IPv6 is vulnerable to numerous attacks like Denial of Service (DoS) and Distributed Denial of Service (DDoS) which is one of the most dangerous attacks executed through ICMPv6 messages that impose security and financial implications. Therefore, an Intrusion Detection System (IDS) is a monitoring system of the security of a network that detects suspicious activities and deals with a massive amount of data comprised of repetitive and inappropriate features which affect the detection rate. A feature selection (FS) technique helps to reduce the computation time and complexity by selecting the optimum subset of features. This paper proposes a method for detecting DDoS flooding attacks (FA) based on ICMPv6 messages using a Binary Flower Pollination Algorithm (BFPA-FA). The proposed method (BFPA-FA) employs FS technology with a support vector machine (SVM) to identify the most relevant, influential features. Moreover, The ICMPv6-DDoS dataset was used to demonstrate the effectiveness of the proposed method through different attack scenarios. The results show that the proposed method BFPA-FA achieved the best accuracy rate (97.96%) for the ICMPv6 DDoS detection with a reduced number of features (9) to half the total (19) features. The proven proposed method BFPA-FA is effective in the ICMPv6 DDoS attacks via IDS. 相似文献
3.
Zaid M. Odibat Cyrille Bertelle M.A. Aziz-Alaoui Gérard H.E. Duchamp 《Computers & Mathematics with Applications》2010,59(4):1462-1472
The differential transform method (DTM) is an analytical and numerical method for solving a wide variety of differential equations and usually gets the solution in a series form. In this paper, we propose a reliable new algorithm of DTM, namely multi-step DTM, which will increase the interval of convergence for the series solution. The multi-step DTM is treated as an algorithm in a sequence of intervals for finding accurate approximate solutions for systems of differential equations. This new algorithm is applied to Lotka–Volterra, Chen and Lorenz systems. Then, a comparative study between the new algorithm, multi-step DTM, classical DTM and the classical Runge–Kutta method is presented. The results demonstrate reliability and efficiency of the algorithm developed. 相似文献
4.
Khamirul Amin Matori Loy Chee Wah Mansor Hashim Ismayadi Ismail Mohd Hafiz Mohd Zaid 《International journal of molecular sciences》2012,13(12):16812-16821
We report on a recycling project in which α-Al2O3 was produced from aluminum cans because no such work has been reported in literature. Heated aluminum cans were mixed with 8.0 M of H2SO4 solution to form an Al2(SO4)3 solution. The Al2(SO4)3 salt was contained in a white semi-liquid solution with excess H2SO4; some unreacted aluminum pieces were also present. The solution was filtered and mixed with ethanol in a ratio of 2:3, to form a white solid of Al2(SO4)3·18H2O. The Al2(SO4)3·18H2O was calcined in an electrical furnace for 3 h at temperatures of 400–1400 °C. The heating and cooling rates were 10 °C/min. XRD was used to investigate the phase changes at different temperatures and XRF was used to determine the elemental composition in the alumina produced. A series of different alumina compositions, made by repeated dehydration and desulfonation of the Al2(SO4)3·18H2O, is reported. All transitional alumina phases produced at low temperatures were converted to α-Al2O3 at high temperatures. The X-ray diffraction results indicated that the α-Al2O3 phase was realized when the calcination temperature was at 1200 °C or higher. 相似文献
5.
Effects of pH and chloride concentration on pitting corrosion of AA6061 aluminum alloy 总被引:1,自引:0,他引:1
Effects of pH solution and chloride (Cl−) ion concentration on the corrosion behaviour of alloy AA6061 immersed in aqueous solutions of NaCl have been investigated using measurements of weight loss, potentiodynamic polarisation, linear polarisation, cyclic polarisation experiment combined with open circuit potential transient technique and optical or scanning electron microscopy.The corrosion behaviour of the AA6061 aluminum alloy was found to be dependant on the pH and chloride concentration [NaCl] of solution. In acidic or slightly neutral solutions, general and pitting corrosion occurred simultaneously. In contrast, exposure to alkaline solutions results in general corrosion. Experience revealed that the alloy AA6061 was susceptible to pitting corrosion in all chloride solution of concentration ranging between 0.003 wt% and 5.5 wt% NaCl and an increase in the chloride concentration slightly shifted both the pitting Epit and corrosion Ecor potentials to more active values. In function of the conditions of treatment, the sheets of the alloy AA6061 undergo two types of localised corrosion process, leading to the formation of hemispherical and crystallographic pits.Polarisation resistance measurements in acidic (pH = 2) and alkaline chloride solutions (pH = 12) which are in good agreement with those of weight loss, show that the corrosion kinetic is minimised in slightly neutral solutions (pH = 6). 相似文献
6.
In a developing country like India, there is an exponential rise in population nutrition requirement. To meet up with both the ends, the agricultural techniques should be perfected for optimal yield and quality. Irrigation and soil property monitoring system using sensors can be automated and operated wirelessly to achieve optimal water supply control and surveillance. The objective of this paper, is to automate the whole wireless sensor network (WSN) system with a control over water pumps and dripper valves. The humidity, temperature and pH sensor’s percepts provide a feedback, to control the water content of the soil. The system has an low-cost and energy reliable ZigBee for sensor data transformation, high-range GPRS system for data storing and analysis, and the whole system is powered by Solar panels which makes it self-sustainable. Customizable options for different crop with different requirements make it a versatile WSN system for automated irrigation based water management. 相似文献
7.
Ibrahim I. T. Attallah K. H. Elsaid M. Fahmy M. H. Abo Zaid L. A. 《Radiochemistry》2019,61(2):220-225
Radiochemistry - Aspirin, one of nonsteroidal anti-inflammatory analgesic drugs, was labeled with 125I with a labeling yield of 85.5% under the following conditions: pH 9, 100 mg of the substrate,... 相似文献
8.
Saif-Ali R Ismail IS Al-Hamodi Z Al-Mekhlafi HM Siang LC Alabsi AM Muniandy S 《International journal of molecular sciences》2011,12(9):5705-5718
The aim of this study was to investigate the association of single nucleotide polymorphisms (SNPs) and haplotypes of potassium voltage-gated channel, KQT-like subfamily, member 1 (KCNQ1) with type 2 diabetes (T2D) in Malaysian Chinese subjects. The KCNQ1 SNPs rs2237892, rs2283228 and rs2237895 were genotyped in 300 T2D patients and 230 control subjects without diabetes and metabolic syndrome. Two logistic regression models of analysis were applied, the first adjusted for age and gender while the second adjusted for age, gender and body mass index. The additive genetic analysis showed that adjusting for body mass index (BMI) even strengthened association of rs2237892, rs2283228 and rs2237895 with T2D (OR = 2.0, P = 5.1 × 10(-5); OR = 1.9, P = 5.2 × 10(-5); OR = 1.9, P = 7.8 × 10(-5), respectively). The haplotype TCA containing the allele of rs2237892 (T), rs2283228 (C) and rs2237895 (A) was highly protective against T2D (Second model; OR = 0.17, P = 3.7 × 10(-11)). The KCNQ1 rs2237892 (TT), and the protective haplotype (TCA) were associated with higher beta-cell function (HOMA-B) in normal subjects (P = 0.0002; 0.014, respectively). This study found that KCNQ1 SNPs was associated with T2D susceptibility in Malaysian Chinese subjects. In addition, certain KCNQ1 haplotypes were strongly associated with T2D. 相似文献
9.
10.
Afzan Adam Abdul Hadi Abd Rahman Nor Samsiah Sani Zaid Abdi Alkareem Alyessari Nur Jumaadzan Zaleha Mamat Basela Hasan 《计算机、材料和连续体(英文)》2021,67(1):761-787
Boundary effect in digital pathology is a phenomenon where the tissue shapes of biopsy samples get distorted during the sampling process. The morphological pattern of an epithelial layer is greatly affected. Theoretically, the shape deformation model can normalise the distortions, but it needs a 2D image. Curvatures theory, on the other hand, is not yet tested on digital pathology images. Therefore, this work proposed a curvature detection to reduce the boundary effects and estimates the epithelial layer. The boundary effect on the tissue surfaces is normalised using the frequency of a curve deviates from being a straight line. The epithelial layer’s depth is estimated from the tissue edges and the connected nucleolus only. Then, the textural and spatial features along the estimated layer are used for dysplastic tissue detection. The proposed method achieved better performance compared to the whole tissue regions in terms of detecting dysplastic tissue. The result shows a leap of kappa points from fair to a substantial agreement with the expert’s ground truth classification. The improved results demonstrate that curvatures have been effective in reducing the boundary effects on the epithelial layer of tissue. Thus, quantifying and classifying the morphological patterns for dysplasia can be automated. The textural and spatial features on the detected epithelial layer can capture the changes in tissue. 相似文献