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Rikako Tabata SungGi Chi Junichiro Yuda Yosuke Minami 《International journal of molecular sciences》2021,22(4)
Several immune checkpoint molecules and immune targets in leukemic cells have been investigated. Recent studies have suggested the potential clinical benefits of immuno-oncology (IO) therapy against acute myeloid leukemia (AML), especially targeting CD33, CD123, and CLL-1, as well as immune checkpoint inhibitors (e.g., anti-PD (programmed cell death)-1 and anti-CTLA4 (cytotoxic T-lymphocyte-associated protein 4) antibodies) with or without conventional chemotherapy. Early-phase clinical trials of chimeric antigen receptor (CAR)-T or natural killer (NK) cells for relapsed/refractory AML showed complete remission (CR) or marked reduction of marrow blasts in a few enrolled patients. Bi-/tri-specific antibodies (e.g., bispecific T-cell engager (BiTE) and dual-affinity retargeting (DART)) exhibited 11–67% CR rates with 13–78% risk of cytokine-releasing syndrome (CRS). Conventional chemotherapy in combination with anti-PD-1/anti-CTLA4 antibody for relapsed/refractory AML showed 10–36% CR rates with 7–24 month-long median survival. The current advantages of IO therapy in the field of AML are summarized herein. However, although cancer vaccination should be included in the concept of IO therapy, it is not mentioned in this review because of the paucity of relevant evidence. 相似文献
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World Wide Web - To solve the problem that users’ retrieval intentions are seldom considered by personalized websites, we propose an improved incremental collaborative filtering (CF)-based... 相似文献
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Anastasia A. Ivanova Chi Phan Ahmed Barifcani Stefan Iglauer Alexey N. Cheremisin 《Journal of surfactants and detergents》2020,23(2):327-338
Surfactant flooding has widely been used as one of the chemically enhanced oil recovery (EOR) techniques. Surfactants majorly influence the interfacial tension, γ, between oil and brine phase and control capillary number and relative permeability behavior and, thus, influence ultimate recovery. Additives, such as nanoparticles, are known to affect surfactant properties and are regarded as promising EOR agents. However, their detailed interactions with surfactants are not well understood. Thus, in this work, we examined the influence of silica nanoparticles on the ability of surfactants to lower γ and to increase viscosity at various temperatures and salinities. Results show that the presence of nanoparticles decreased γ between n-decane and various surfactant formulations by up to 20%. It was found that γ of nanoparticles–surfactant solutions passed through a minimum at 35 °C when salt was added. Furthermore, the viscosity of cationic surfactant solutions increased at specific salt (1.5 wt.%) and nanoparticle (0.05 wt.%) concentrations. Results illustrate that selected nanoparticles–surfactant formulations appear very promising for EOR as they can lower brine/n-decane interfacial tension and act as viscosity modifiers of the injected fluids. 相似文献
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Wireless Personal Communications - With the astounding growth of the information era, the amount of data increases at high speed. However, a significant fraction of the data residing in storage is... 相似文献
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Efficient energy and temperature management techniques are essential elements for operators of cloud data centers. Dynamic virtual machine (VM) consolidation using live migration techniques presents a great opportunity for cloud service providers to adaptively reduce energy consumption and optimize their resource utilization. In recent studies, power consumption readings of individual physical hosts were chosen as the main monitoring parameters in their allocation policies, whereas very few have considered host temperature, which has shown to have a negative impact on server reliability, as a migration criterion. In this work, a thermal-aware VM consolidation mechanism is proposed for resource allocation optimization and server reliability assurance. We consider the variability in host temperature as a migration criterion to avoid outage incidents via having better VM consolidations. Extensive simulation results obtained from CloudSim show the promising performance of the proposed mechanism in energy saving while reducing the number of server outage incidents due to fluctuations in host temperature. 相似文献