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排序方式: 共有2358条查询结果,搜索用时 15 毫秒
1.
This paper reported an effectiveness of pre-cold rolling-induced{332}\113[twins combined with subsequent isothermal x-phase formation for enhancement of uniform elongation in a b-type Ti–15Mo alloy with high yield strength level.Mechanical{332}\113[twins were induced by cold rolling with an thickness reduction of 5%,which had little effect on x-phase precipitation after aging at 573 K for 3.6 ks.Twinning after the cold rolling was further activated during tensile deformation,even with the presence of isothermal x-phase.This combination of twins and x-phase enhanced uniform elongation from 0 to 9%at yield strength level of 890 MPa.The high yield strength was mainly dominated by dislocation slip due to the isothermal x-phase formation,and early onset of plastic instability after yielding was hindered due to the pre-cold rolling-induced twins.Dynamic microstructural refinement was induced by further twinning activation during deformation,which resulted in high work hardening rate corresponding enhancement of uniform elongation. 相似文献
2.
Makoto Morinaga Naoki Sako Mari Isobe Sachiko Lee-Hotta Hideshi Sugiura Satoshi Kametaka 《International journal of molecular sciences》2021,22(6)
Cachexia is a multifactorial syndrome characterized by muscle loss that cannot be reversed by conventional nutritional support. To uncover the molecular basis underlying the onset of cancer cachectic muscle wasting and establish an effective intervention against muscle loss, we used a cancer cachectic mouse model and examined the effects of aerobic exercise. Aerobic exercise successfully suppressed muscle atrophy and activated adiponectin signaling. Next, a cellular model for cancer cachectic muscle atrophy using C2C12 myotubes was prepared by treating myotubes with a conditioned medium from a culture of colon-26 cancer cells. Treatment of the atrophic myotubes with recombinant adiponectin was protective against the thinning of cells through the increased production of p-mTOR and suppression of LC3-II. Altogether, these findings suggest that the activation of adiponectin signaling could be part of the molecular mechanisms by which aerobic exercise ameliorates cancer cachexia-induced muscle wasting. 相似文献
3.
Hiroyuki Koide Satoshi Hirano Takafumi Ide Kazuhiro Saito Hikaru Suzuki Go Yasuno Yoshitaka Hamashima Sei Yonezawa Naoto Oku Tomohiro Asai 《Advanced functional materials》2021,31(3):2005641
Protein affinity reagents (e.g., antibodies) are often used for basic research, diagnostics, separations, and disease therapy. Although a lot of “synthetic” protein affinity reagents have been developed as a cost-effective alternative to antibodies, their low biocompatibility is a considerable problem for clinical application. Lipid nanoparticles (LNP) represent a highly biocompatible drug delivery agent. However, little has been reported that LNP itself works as a protein affinity reagent in living animals. Here, LNP is engineered for binding to and neutralizing a target toxic peptide in living animals by multifunctionalization with amino acid derivatives. Multifunctionalized LNP (MF-LNP) is prepared using amino acid derivative-conjugated lipids. Optimized MF-LNP exhibits nanomolar affinity to the target toxic peptide and inhibits toxic peptide-dependent hemolysis and cytotoxicity. In addition, MF-LNP captures and neutralizes the toxic peptide after intravenous injection in the bloodstream; in addition, MF-LNP does not release the toxic peptide in the accumulated organ. These results reveal the potential of using LNP as a highly biocompatible protein affinity reagent such as an antidote. 相似文献
4.
Tsuneaki Matsudaira Masashi Wada Naoki Kawashima Miyuki Takeuchi Daisaku Yokoe Takeharu Kato Masasuke Takata Satoshi Kitaoka 《Journal of the European Ceramic Society》2021,41(5):3150-3160
Mass transfer in polycrystalline Yb2SiO5 wafers with precise composition control was evaluated and analyzed by oxygen permeation experiments at high temperatures using an oxygen tracer. Oxygen permeation proceeded due to mutual grain boundary diffusion of oxide ions and Yb ions without synergistic effects such as acceleration or suppression. The oxygen shielding properties of Yb2SiO5 were compared with those of the other line compounds such as Yb2Si2O7 and Al2O3 based on the determined mass transfer parameters. It was found that the more preferentially an oxide ion diffuses in the grain boundary compared to the interior of the grain, the greater the effect of suppressing the movement of the oxide ion by applying an oxygen potential gradient becomes. 相似文献
5.
Makoto Koike Tetsunori Suzuoki Tadashi Takeuchi Takayuki Homma Satoshi Hariu Yoshitaka Takeuchi 《International Journal of Hydrogen Energy》2021,46(50):25689-25698
This work demonstrated the first-ever cold-start operation of an ammonia (NH3)-fueled four-cylinder spark ignition engine with an on-board fuel reformer, applying autothermal reforming. In this system, an electrically heated NH3-air mixture was provided to a reforming catalyst and approximately 3 s was found to elapse between the start of engine rotation and the onset of combustion. Stable fast idle operation in conjunction with a cold start was realized with a H2-to-NH3 molar ratio of 2:1. Nearly zero NH3 emissions were achieved during cold start and fast idle until the engine warmed up, by adsorbing unburned NH3 passing through a three-way catalyst before the catalyst was sufficiently warmed up. The NH3 adsorption capacity of this system could be regenerated during the engine warm-up when the engine was running under lean conditions. 相似文献
6.
7.
Ichiro Fujii Shin Ariizumi Shintaro Ueno Chikako Moriyoshi Yoshihiro Kuroiwa Satoshi Wada 《Ceramics International》2018,44(9):10657-10662
We fabricated xBaTiO3 (BT)/(1-x)[BaTiO3-Bi(Mg1/2Ti1/2)O3-BiFeO3] (BT-BMT-BF)?+?0.1?wt%MnCO3 composites by spark plasma sintering and investigated the effect of BT content x, BT powder size, and BT-BMT-BF composition on piezoelectric properties. For xBT/(1-x)(0.3BT-0.1BMT-0.6BF) +?0.1?wt%MnCO3 (x?=?0–0.75) composites with a 0.5-µm BT powder, the dielectric constant was increased with x, and the relative density was decreased at x?=?0.67 and 0.75, creating optimum BT content of x?=?0.50 with a piezoelectric constant d33 of 107?pC/N. When a larger 1.5-µm BT powder was utilized for the composite with x?=?0.50, the d33 value increased to 150?pC/N due to the grain size effect of the BT grains. To compensate for a compositional change from the optimum 0.3BT-0.1BMT-0.6BF due to partial diffusion between the BT and 0.3BT-0.1BMT-0.6BF grains, a 0.5BT/0.5(0.275BT-0.1BMT-0.625BF)?+?0.1?wt%MnCO3 composite with the 1.5-µm BT powder was fabricated. We obtained an increased d33 value of 166?pC/N. These results provided a useful composite design to enhance the piezoelectric properties. 相似文献
8.
Hyeonseok Jee Sumin Im Manabu Kanematsu Hiroshi Suzuki Satoshi Morooka Koyama Taku Akihiko Machida Sungchul Bae 《Journal of the American Ceramic Society》2020,103(12):7188-7201
We examined the effect of incorporating high-volume fly ash on the atomic arrangement and interatomic deformation behavior of calcium silicate hydrates in tricalcium silicate paste upon exposure to external forces. The interatomic structural changes and strains under compressive load were assessed using synchrotron in situ high-energy X-ray scattering-based atomic pair distribution function analysis. Three different types of strains, which were (a) macroscopic strains from gauges on the surfaces of specimen, (b) strains in a reciprocal space (Bragg peak shift), and (c) strains in real space (PDF peak shift), were compared to each other. All monitored and calculated strains for tricalcium silicate-fly ash (50 wt% fly ash) paste were compared with the counterparts of the pure tricalcium silicate paste. Pair distribution function analysis in the range of r < 10 Å indicated that the atomic arrangement of tricalcium silicate-fly ash was similar to that of synthetic calcium silicate hydrates followed by that of pure tricalcium silicate paste. Moreover, the pair distribution function refinement results revealed that the calcium silicate hydrate structure in tricalcium silicate-fly ash paste was similar to tobermorite 11 Å, unlike that in pure tricalcium silicate paste. The interatomic strain of tricalcium silicate-fly ash in the real space (r < 20 Å) was smaller than that of tricalcium silicate under compression, which suggested that the incompressibility of calcium silicate hydrates at atomistic scale was enhanced by the incorporation of fly ash into it. This was likely to be caused by the increased silicate polymerization of calcium silicate hydrates, which was attributed to the increase in the amount of silicate in their structure via the addition of fly ash. 相似文献
9.
10.
Futoshi Nakamura Nobuo Ishiyama Satoshi Yamanaka Motoki Higa Takumi Akasaka Yoshiko Kobayashi Satoru Ono Nao Fuke Munehiro Kitazawa Junko Morimoto Yasushi Shoji 《河流研究与利用》2020,36(6):921-933
In recent years, we have experienced mega‐flood disasters in Japan due to climate change. In the last century, we have been building disaster prevention infrastructure (artificial levees and dams, referred to as “grey infrastructure”) to protect human lives and assets from floods, but these hard protective measures will not function against mega‐floods. Moreover, in a drastically depopulating society such as that in Japan, farmland abandonment prevails, and it will be more difficult to maintain grey infrastructure with a limited tax income. In this study, we propose the introduction of green infrastructure (GI) as an adaptation strategy for climate change. If we can use abandoned farmlands as GI, they may function to reduce disaster risks and provide habitats for various organisms that are adapted to wetland environments. First, we present a conceptual framework for disaster prevention using a hybrid of GI and conventional grey infrastructure. In this combination, the fundamental GI, composed of forests and wetlands in the catchment (GI‐1) and additional multilevel GIs such as flood control basins that function when floodwater exceeds the planning level (GI‐2) are introduced. We evaluated the flood attenuation function (GI‐1) of the Kushiro Wetland using a hydrological model and developed a methodology for selecting suitable locations of GI‐2, considering flood risk, biodiversity and the distribution of abandoned farmlands, which represent social and economic costs. The results indicated that the Kushiro Wetland acts as a large natural reservoir that attenuates the hydrological peak discharge during floods and suitable locations for introducing GI‐2 are concentrated in floodplain areas developing in the downstream reaches of large rivers. Finally, we discussed the network structure of GI‐1 as a hub and GI‐2 as a dispersal site for conservation of the Red‐crowned Crane, one of the symbolic species of Japan. 相似文献