Chromophore-Free Sealing and Repair of Soft Tissues Using Mid-Infrared Light-Activated Biosealants

Poor strength, infection, leakage, long procedure times, and inflammation limit the efficacy of common tissue sealing devices in surgeries and trauma. Light-activated sealing is attractive for tissue sealing and repair, and can be facilitated by the generation of local heat following absorption of nonionizing laser energy by chromophores. Here, the inherent ability of biomaterials is exploited to absorb nonionizing, mid-infrared (midIR) light in order to engender rapid photothermal sealing and repair of soft tissue wounds. In this approach, the biomaterial simultaneously acts as a photothermal convertor as well as a biosealant, which dispenses the need for exogeneous light-absorbing nanoparticles or dyes. Biomechanical recovery, mathematical modeling, histopathology analyses, tissue strain mapping using digital imaging correlation, and visualization of the biosealant-tissue interface using hyperspectral imaging indicate superior performance of midIR sealing in live mice compared to conventional sutures and glue. The midIR-biosealant approach demonstrates rapid sealing of soft tissues, improves cosmesis, lowers potential for scarring, obviates safety concerns because of the nonionizing light used, and allows adoption of a wide diversity of biomaterials. Taken together, the studies demonstrate a novel advance both in biomaterials for surgical sealing along with the use of nonionizing midIR light, with high potential for clinical translation.     

An epidemic of roller-blade injuries in children

Roller blading is a new and increasingly popular leisure activity in many countries. We reviewed 110 consecutive patients with roller-blade injuries between 1 January and 30 June 1996. The patients ranged from 4 to 14 years in age (mean 6.5 years). Eighty-three (75.4%) sustained injuries to the upper limb and 27 (24.5%) injured the lower limb. Fifty-six patients, were girls and 54 were boys. Of the 110 patients, 79 (72.7%) sustained fractures, 28 (25.4%) soft tissue injuries and 3 (2.7%) dislocations. Eighty-three (75.4%) of the patients wore no protective equipment on the limbs. Four months following injury 103 (93.6%) patients were fully recovered. The mean duration of school absence was 3 days. Subsequently 101 children returned to using roller-blades following injury. Seventy-three (66.3%) of these now use protective equipment. We found that injuries were unrelated to age or duration of roller-blading experience or to the brand-name of roller blades used, and that most of our patients wore no protective equipment at the time of injury.     

Supervised Multi‐Rejector of Periodic Disturbances for Nonlinear Systems Using Decoupled State Multimodel

In this paper, a multi‐rejector of periodic disturbances is proposed for discrete‐time nonlinear systems represented by a decoupled state multimodel. We report a decoupled state multimodel repetitive‐predictive control based on a supervised algorithm to ensure reference trajectory tracking and periodic disturbances rejection. Partial predictors associated to the local controllers make the best choice of the most valid partial controller that meets the desired closed loop performances. The effectiveness of the supervised multi‐rejector is shown via a simulation example. The obtained results are satisfactory and show a good rejection of periodic disturbances and reference trajectory tracking.     

Efficient hardware architecture of 2D-scan-based wavelet watermarking for image and video

This paper describes an efficient hardware architecture of 2D-Scan-based-Wavelet watermarking for image and video. The potential application for this architecture includes broadcast monitoring of video sequences for High Definition Television (HDTV) and DVD protection and access control. The proposed 2D design allows even distribution of the processing load onto a set of filters, with each set performing the calculation for one dimension according to the scan-based process. The video protection is achieved by the insertion of watermarks bank within the middle frequency of wavelet coefficients related to video frames by their selective quantization. The 2-D DWT is applied for both video stream and watermark in order to make the watermarking scheme robust and perceptually invisible. The proposed architecture has a very simple control part, since the data are operated in a row-column-slice fashion. This organization reduces the requirement of on-chip memory. In addition, the control unit selects which coefficient to pass to the low-pass and high-pass filters. The on-chip memory will be small as compared to the input size since it depends solely on the filter sizes. Due to the pipelining, all filters are utilized for 100% of the time except during the start-up and wind-down times. The major contribution of this research is towards the selection of appropriate real time watermarking scheme and performing a trade-off between the algorithmic aspects of our proposed watermarking scheme and the hardware implementation technique. The hardware architecture is designed, as a watermarking based IP core with the Avalon interface related to NIOS embedded processor, and tested in order to evaluate the performance of our proposed watermarking algorithm. This architecture has been implemented on the Altera Stratix-II Field Programmable Gate Array (FPGA) prototyping board. Experimental results are presented to demonstrate the capability of the proposed watermarking system for real time applications and its robustness against malicious attacks.     

Hybrid micro electrostatic actuator

A hybrid micro-electrostatic actuator is presented. The actuator integrates a vertical comb driving (VCD) unit and a parallel-plate driving (PPD) unit. The hybrid actuator is fabricated using a one structural layer microfabrication process, i.e., MetalMUMPs instead of a two-layer microfabrication process needed for traditional vertical comb-drive actuators by taking advantage of the residual stress gradient in the MetalMUMPs nickel layer, which raises the moving parts of the actuator above the substrate after release. The hybrid actuator significantly simplifies the fabrication process for vertical comb-drive actuators, i.e., turning a process requiring two structural layers into a process requiring only one structural layer and thus avoids any misalignment between the two layers. The hybrid actuator can generate larger force and then a larger displacement than the actuator having only the VCD with the same area since no extra space is needed for the PPD unit which uses the moving electrode existing in the VCD unit and a fixed electrode under the VCD unit. The VCD and PPD units in the hybrid actuator are subject to the same driving voltage and work together to pull the moving parts of the actuator downward. A model is established for the hybrid actuator to analyze its displacement. The analytical results show that displacement of the moving part of the hybrid actuator is about half of the gap between the electrodes of the PPD unit. Prototypes are fabricated and tested. With a driving voltage of 150 V, the hybrid actuator achieved a measured displacement of 6.48 µm.     

Fault and attack management in all-optical networks

Network management for optical networks faces additional security challenges that arise by using transparent optical network components in communication systems. While some available management mechanisms are applicable to different types of network architectures, many of these are not adequate for all-optical networks. These have unique features and requirements in terms of security and quality of service, thus requiring a much more targeted approach in terms of network management. In this article we consider management issues with particular emphasis on complications that arise due to the unique characteristics and peculiar behaviors of transparent network components. In particular, signal quality monitoring is still a major complication in all-optical networks. Despite new methods for detection and localization of attacks having been proposed, no robust standards or techniques exist to date for guaranteeing the quality of service in these networks. Therefore, sophisticated mechanisms that assist in managing and assessing the proper function of transparent network components are highly desirable. Accordingly, we present an algorithm for multiple attack localization and identification that can participate in some tasks for fault management of all-optical networks     

Requirements Scenarios Formalization Technique: N Versions Towards One Good Version

Using a notion of simulation introduced by de Roever et al. [9], we define a corresponding notion of bisimulation which we will use as a test to detect formality discrepancy between two formal versions of the same informal scenario. We will also use it, combined with the relation part of, as a test to detect discrepancy between two formal scenarios describing two different informal scenarios. We will describe a way of implementing these formality discrepancy tests in the work place. We call it N-version technique for scenario formalization. This technique allows us to (1) detect formality discrepancy between formal scenario versions corresponding to the same scenario, to (2) validate, for the given scenario, the formalization obtained by a specifier against another obtained by another specifier before bothering the stake-holder with problems of the specifier's creation (formalization errors), and to (3) detect formality discrepancy between the formal scenarios of different informal scenarios if their respective spaces share at least one component.     

Some investigations into the optimal dimensional synthesis of parallel robots

In this paper, we will perform a comparison between two approaches of dimensional synthesis of parallel robots. The first one concerns the single-objective optimization approach; in this case, the dimensional synthesis is expressed by taking into account only one performance criterion but enables to get a final solution if it exists. The second one concerns the multi-objective optimization approach; it enables to simultaneously take into account several performance criteria. However, this approach appears to provide a set of solutions instead of a single expected final solution which should directly enable to carry out the structural synthesis. In fact, the search of a single final solution is postponed to a further step where the designers have to impose and/or restrict certain parameters. And we will establish if it is really necessary to make a multi-objective optimization approach or if a single-objective is sufficient to reach the objectives set in the specifications (user requirements). A discussion is proposed concerning the arising questions related to each approach and leading to the optimal dimensional synthesis. The PAR2 robot with two degree-of-freedom is used to exemplify the analysis and the comparison of the two approaches. The proposed comparison can be applied to any classes of parallel robots.     

Recovery of Hydroxytyrosol Rich Extract from Two‐Phase Chemlali Olive Pomace by Chemical Treatment

Abstract: A very simple method is proposed to produce hydroxytyrosol, a commercially unavailable compound with well‐known biological properties which justify a potential commercial application. The 2‐phase Chemlali olive pomace is selected as substrate for chemical treatment. Different conditions of chemical treatment, including concentration of acid and alkaline solutions, time and temperature, were assayed. A high amount of hydroxytyrosol (1360 mg/kg of fresh 2‐phase olive pomace) was obtained using water bath after treatment at 80 °C for 90 min with 1 M of H₃PO₄. However, treatment of 2‐phase Chemlali olive pomace using autoclave apparatus could produce a large amount of hydroxytyrosol (1993.60 and 1515.88 mg/kg of fresh alperujo, 1 M acid and basic catalyst, respectively). By taking into consideration practical and economic aspects, acid‐catalyzed treatment was more effective using autoclave conditions, whereas the alkali catalyzed conditions were not very suitable. This study could provide useful information for industry to produce the potentially bioactive compound. Practical Application: The 2‐phase Chemlali olive pomace is selected as substrate for chemical treatment. Treatment of “alperujo” using water bath or autoclave apparatus was carried out. A high amount of hydroxytyrosol was obtained using autoclave apparatus.