Korrosionsverhalten von Plasma- Heißdraht-Auftrag-Schweißungen. Teil I: Beständigkeit von auftraggeschweißten Nickelbasislegierungen gegen Loch- und interkristalline Korrosion

The corrosion properties of Plasma-Hot-Wire-Surfacing Part one: resistance of Nickel-base-alloy claddings against pitting and intergranular attack This paper describes measurements at claddings of nickel-based-alloys C 276, C 4 and C 22 on the St 52-3 steel substrat produced by Plasma-Hot-Wire-Surfacing (PHS). The correct heat control during the welding process is a crucial factor for the preparation of nearly precipitate-free claddings. For this reason it was necessary to optimize all the process data. The claddings itself as well as the rolled reference material (both of nearly the same chemical composition) were examined by means of metallografical and microanalytical techniques. Corrosion measurements show, that the composite materials exhibit high resistance both against pitting and intergranular corrosion and comparable to the properties of the rolled reference material. This was shown by determination of the critical pitting temperature in quinary salt solution, by electrochemical techniques in acidic chloride solution and by investigation in iron-(III)-sulfate-sulphuric acid solution.     

A Review of Pathways for Building Fire Spread in the Wildland Urban Interface Part II: Response of Components and Systems and Mitigation Strategies in the United States

Structure loss in wildland fires has significantly increased over the past few decades, affected by increased development in rural areas, changing fuel management policies, and climate change, all of which are projected to increase in the future. This paper is Part II of a two-part review, which presents a summary of fundamental and applied research on pathways to fire spread in the wildland urban interface. Part I discussed the fundamentals of wildland fire spread via radiative heat transfer, direct flame contact, and firebrand exposure. Here in Part II, we cover the response of building components and systems, as well as mitigation strategies used to prevent fire spread into and within communities in the United States. Post-fire investigations, full-scale structural testing, individual component testing, and combined systems or assembly testing have been used to identify building component and system vulnerabilities such as roofs, vents, siding, decks, fences, and mulch. Using results from these tests and investigations at different scales, some knowledge has been gained on specific vulnerabilities and the effectiveness of mitigation strategies, but a quantitative framework has not yet been established. On a community level, the layout of structures and the space between them has been shown to be incredibly important in mitigating wildfire risk. More locally, defensible space around homes has been effective in mitigating exposure from both radiation and direct flame contact. Firebrands still remain a challenge; however, many design recommendations have been proposed to harden structures against firebrand exposures. Recommendations for future research and development are also presented.     

The Propensity of Wooden Crevices to Smoldering Ignition by Firebrands

Fire Technology - Fires occurring at the wildland-urban interface (WUI) have rapidly increased in frequency and severity over the past few decades. As a result of these extreme fires, multiple...     

Targeted Synthesis of Complex Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-ones by Intramolecular Cyclization of Azomethine Ylides: Highly Potent MDM2–p53 Inhibitors

Mouse double minute 2 (MDM2) is a main and direct inhibitor of the crucial tumor suppressor p53. Reports from initial clinical trials showed that blocking this interaction with a small-molecule inhibitor can have great value in the treatment of cancer for patients with p53 wild-type tumors; however, it also revealed dose-limiting hematological toxicities and drug-induced resistance as main issues. To overcome the former, an inhibitor with superior potency and pharmacokinetic properties to ultimately achieve full efficacy with less-frequent dosing schedules is required. Toward this aim, we optimized our recently reported spiro-oxindole inhibitors by focusing on the crucial interaction with the amino acid side chain of His96_MDM2. The designed molecules required the targeted synthesis of structurally complex spiro[indole-3,2′-pyrrolo[2,3-c]pyrrole]-2,4′-diones for which we developed an unprecedented intramolecular azomethine ylide cycloaddition and investigated the results by computational methods. One of the new compounds showed superior cellular potency over previously reported BI-0252. This finding is a significant step toward an inhibitor suitable to potentially mitigate hematological on-target adverse effects.     

Downward Flame Spread Rate Over PMMA Rods Under External Radiant Heating

Fire Technology - There are multiple situations in which fires may occur at environmental conditions that are different than standard atmospheric conditions. Changes in ambient pressure, oxygen...     

Review of Pathways for Building Fire Spread in the Wildland Urban Interface Part I: Exposure Conditions

While the wildland–urban interface (WUI) is not a new concept, fires in WUI communities have rapidly expanded in frequency and severity over the past few decades. The number of structures lost per year has increased significantly, due in part to increased development in rural areas, fuel management policies, and climate change, all of which are projected to increase in the future. This two-part review presents an overview of research on the pathways for fire spread in the WUI. Recent involvement of the fire science community in WUI fire research has led to some great advances in knowledge; however, much work is left to be done. While the general pathways for fire spread in the WUI (radiative, flame, and ember exposure) are known, the exposure conditions generated by surrounding wildland fuels, nearby structures or other system-wide factors, and the subsequent response of WUI structures and communities are not well known or well understood. This first part of the review covers the current state of the WUI and existing knowledge on exposure conditions. Recommendations for future research and development are also presented for each part of the review.