Surface modification of multiwalled carbon nanotubes via surface RAFT copolymerization method and capecitabine-loaded anticancer hydrogel for controlled drug delivery in stomach

ABSTRACT

In our work, reversible addition-fragmentation chain transfer (RAFT)/carbon nanotube (CNT)/acrylic acid (AA)/acrylamide (AAm) nanocomposite was synthesized by living radical polymerization. The structure and surface morphology of the synthesized RAFT-CNT-Hydrogel nanocomposites were analyzed by FTIR, ¹HNMR, SEM, TEM, XRD, and TGA/DTG techniques. The results indicated that PAA/AAm chains grafted with CNT by RAFT polymerization. RAFT-CNT-Hydrogel nanocomposites for drug release investigated in different buffers resulted in a strong pH-sensitive behavior. In total, the obtained hydrogel drug-delivery systems are presented a proper effect versus stomach cancer in vitro and in vivo, and it can be used as candidates for controlled release of anticancer drugs in stomach with exalted remedial agents.     

Efficient designs of reversible sequential circuits

The Journal of Supercomputing - Recently, the synthesis of reversible sequential circuits has attracted researchers’ attention for implementing low-power logic designs. So far, the direct and...     

Voting among virtually generated versions of a classification problem

A classifier combining strategy, virtual voting by random projection (VVRP), is presented. VVRP takes advantage from the bounded distortion incurred by random projection in order to improve accuracies of stable classifiers like discriminant analysis (DA) where existing classifier combining strategies are known to be failed. It uses the distortion to virtually generate different training sets from the total available training samples in a way that does not have the potential for overfitting. Then, a majority voting combines the base learners trained on these versions of the original problem. VVRP is very simple and just needs determining a proper dimensionality for the versions, an often very easy task. It is shown to be stable in a very large region of the hyperplane constructed by the dimensionality and the number of the versions. VVRP improves the best state-of-the-art DA algorithms in both small and large sample size problems in various classification fields.     

Bile acid metabolism in mammals: VI. Effect of ethionine upon bile acids of rat bile

Sex differences in the effect of ethionine upon rat liver metabolism prompted our investigation into possible sex differences in the effect of ethionine upon bile acid metabolism. The bile ducts of 24 rats, 12 male and 12 female, were cannulated. After 1 hr of bile collection, 6 rats of each sex were given ethionine, 1 mg/g body wt, by feeding tube. The bile acid composition of the bile collected during the subsequent 4 hr was analyzed by combined thin layer and gas chromatography. Ethionine induced a reduction in bile flow (3rd and 4th hr) and in bile acid concentration (4th hr) in female rats. The amino acid had no effect upon bile flow but did increase biliary secretion of bile acids (1st and 2nd hr) in male rats. Cholic acid accounted for the bulk of the reduction in total bile acid secretion in the female studies. The increase in total bile acid secretion in the male studies involved all bile acids. The effects of ethionine upon bile acid secretion were delayed in the female studies, immediate in the male. The changes in bile acid secretion involved only the taurine conjugates in the female studies, both taurine and glycine conjugates in the male. There are substantial sex differences in the effect of ethionine upon bile acid metabolism in the rat.     

On the new solutions for a fully fuzzy linear system

In this paper, we propose a new method to present a fuzzy trapezoidal solution, namely “suitable solution”, for a fully fuzzy linear system (FFLS) based on solving two fully interval linear systems (FILSs) that are 1-cut and 0-cut of the related FILS. After some manipulations, two FILSs are transformed to 2n crisp linear equations and 4n crisp linear nonequations and n crisp nonlinear equations. Then, we propose a nonlinear programming problem (NLP) to computing simultaneous (synchronic) equations and nonequations. Moreover, we define two other new solutions namely, “fuzzy surrounding solution” and “fuzzy peripheral solution” for an FFLS. It is shown that the fuzzy surrounding solution is placed in a tolerable fuzzy solution set and the fuzzy peripheral solution is placed in a controllable fuzzy solution set. Finally, some numerical examples are given to illustrate the ability of the proposed methods.     

The effect of epoxy‐polyester hybrid resin on mechanical properties,rheological behavior,and water absorption of polypropylene wood flour composites

The effect of epoxy resin on mechanical and Rheological properties, and moisture absorption of wood flour polypropylene composites (WPCs) were investigated. The reactive mixing of epoxy resin with 30, and 40 wt% wood flour and polypropylene (PP) was carried out in twin screw extruder with a special screw elements arrangement. PP grafted maleic anhydrides (MPP) were used as coupling agent to improve the interfacial interactions of wood flour, epoxy resin, and PP. The tensile strength of composites decreased, and elastic modulus and moisture absorption increased with increasing epoxy resin content. The complex viscosity η* increased with increasing epoxy resin content of composites, and a synergistic effect in increasing the η* was observed at 3 wt% resin. The epoxy resin modified wood‐PP composites that chemically coupled by MPP showed minimum water absorption with highest elastic modulus. The experimental oscillation rheologyical data were used to drive a model to predict the flow behavior of WPCs, in a wide range of frequencies. POLYM. ENG. SCI., 47:2041–2048, 2007. © 2007 Society of Plastics Engineers     

Heavy-fuel flame radiation in gas turbine combustors—exploratory results

With lower costs and greater availability, heavy fuel oil appears as an attractive alternative to the conventional gas oil used in industrial gas turbines. However, higher levels of radiation and smoke are expected, and this note reports on some preliminary tests made with a combustion chamber burning fuels of different carbon content, ranging from kerosine to a 25% blend of residual fuel oil in gas oil, at a chamber pressure of 10 atm^*. The combustion rig was equipped with a total-radiation pyrometer and black-body furnace capable of measurement at different axial stations along the spray-stabilized flame. The presence of the residual fuel oil in the gas oil was found to promote significant increases in the mean levels of radiation, emissivity and smoke density, with a modest increase in liner temperature.     

Applying gravitational search algorithm in the QoS-based Web service selection problem

With the growing use of service-oriented architecture for designing next generation software systems,the service composition problem and its execution complexity have become even more important in resp...     

Observer-based adaptive fuzzy control for a class of nonlinear time-delay systems

An observer-based adaptive fuzzy control is presented for a class of nonlinear systems with unknown time delays. The state observer is first designed, and then the controller is designed via the adaptive fuzzy control method based on the observed states. Both the designed observer and controller are independent of time delays. Using an appropriate Lyapunov-Krasovskii functional, the uncertainty of the unknown time delay is compensated, and then the fuzzy logic system in Mamdani type is utilized to approximate the unknown nonlinear functions. Based on the Lyapunov stability theory, the constructed observer-based controller and the closed-loop system are proved to be asymptotically stable. The designed control law is independent of the time delays and has a simple form with only one adaptive parameter vector, which is to be updated on-line. Simulation results are presented to demonstrate the effectiveness of the proposed approach.