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1.
Nikhil K. Tulsian Valerie Jia-En Sin Hwee-Ling Koh Ganesh S. Anand 《International journal of molecular sciences》2021,22(10)
Phosphodiesterases (PDEs) hydrolyze cyclic nucleotides to modulate multiple signaling events in cells. PDEs are recognized to actively associate with cyclic nucleotide receptors (protein kinases, PKs) in larger macromolecular assemblies referred to as signalosomes. Complexation of PDEs with PKs generates an expanded active site that enhances PDE activity. This facilitates signalosome-associated PDEs to preferentially catalyze active hydrolysis of cyclic nucleotides bound to PKs and aid in signal termination. PDEs are important drug targets, and current strategies for inhibitor discovery are based entirely on targeting conserved PDE catalytic domains. This often results in inhibitors with cross-reactivity amongst closely related PDEs and attendant unwanted side effects. Here, our approach targeted PDE–PK complexes as they would occur in signalosomes, thereby offering greater specificity. Our developed fluorescence polarization assay was adapted to identify inhibitors that block cyclic nucleotide pockets in PDE–PK complexes in one mode and disrupt protein-protein interactions between PDEs and PKs in a second mode. We tested this approach with three different systems—cAMP-specific PDE8–PKAR, cGMP-specific PDE5–PKG, and dual-specificity RegA–RD complexes—and ranked inhibitors according to their inhibition potency. Targeting PDE–PK complexes offers biochemical tools for describing the exquisite specificity of cyclic nucleotide signaling networks in cells. 相似文献
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Ramasubba Reddy Palem Ganesh D. Shimoga Zuzana Kronekova Monika Sláviková Petr Saha 《国际聚合物材料杂志》2018,67(1):1-10
Chitosan–silver nanocomposites (CS-HDA-AgNCs) was prepared using chitosan, biogenic silver nanocomposites, and crosslinker, hexamethylene 1,6-di(amino carboxysulfonate) (HDA). The film is flexible and transparent. Its physical, mechanical, thermal, hydrophilicity, and swelling properties were improved by HDA (2.5%). The antimicrobial activity of CS-HDA-AgNCs were not displayed any remarkable zone of inhibition but showed toxic effect in the presence of normal 3T3 fibroblasts and cancer HeLa cells. It decreases to ca. 5–7% for both cell lines. In conclusion, it can be mentioned that the CS-HDA-AgNCs, a kind of new functional biomaterial, could be useful for health-care applications. 相似文献
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Guo Jianmei Liang Jia Hui Shi Kai Yang Dingyu Zhang Jingsong Czarnecki Krzysztof Ganesh Vijay Yu Huiqun 《Software and Systems Modeling》2019,18(2):1447-1466
Software and Systems Modeling - A key challenge to software product line engineering is to explore a huge space of various products and to find optimal or near-optimal solutions that satisfy all... 相似文献
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Agrawal Prachi Ganesh Talari Mohamed Ali Wagdy 《Neural computing & applications》2021,33(11):5989-6008
Neural Computing and Applications - To obtain the optimal set of features in feature selection problems is the most challenging and prominent problem in machine learning. Very few human-related... 相似文献
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Recent developments in nanotechnology transforming the agricultural sector: a transition replete with opportunities 总被引:1,自引:0,他引:1 下载免费PDF全文
Dae‐Young Kim Avinash Kadam Surendra Shinde Rijuta Ganesh Saratale Jayanta Patra Gajanan Ghodake 《Journal of the science of food and agriculture》2018,98(3):849-864
The applications and benefits of nanotechnology in the agricultural sector have attracted considerable attention, particularly in the invention of unique nanopesticides and nanofertilisers. The contemporary developments in nanotechnology are acknowledged and the most significant opportunities awaiting the agriculture sector from the recent scientific and technical literature are addressed. This review discusses the significance of recent trends in nanomaterial‐based sensors available for the sustainable management of agricultural soil, as well as the role of nanotechnology in detection and protection against plant pathogens, and for food quality and safety. Novel nanosensors have been reported for primary applications in improving crop practices, food quality, and packaging methods, thus will change the agricultural sector for potentially better and healthier food products. Nanotechnology is well‐known to play a significant role in the effective management of phytopathogens, nutrient utilisation, controlled release of pesticides, and fertilisers. Research and scientific gaps to be overcome and fundamental questions have been addressed to fuel active development and application of nanotechnology. Together, nanoscience, nanoengineering, and nanotechnology offer a plethora of opportunities, proving a viable alternative in the agriculture and food processing sector, by providing a novel and advanced solutions. © 2017 Society of Chemical Industry 相似文献
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Ganesh Mahidhara Deepshikha Gupta Ch. Sasikala Ch. V. Ramana 《International Journal of Hydrogen Energy》2021,46(4):3090-3104
In this study, Rubrivivax benzoatilyticus JA2T (=ATCC BAA-35T = JCM 13220T = MTCC 7087T), an anoxygenic photosynthetic bacterium, was subjected to altered conditions and observed for changes in power outcome in the two chambered microbial fuel cells (MFCs), the basis of which was established using metabolomic studies. This is an extension to our previous studies, which showed that, under photo heterotrophic conditions, glucose in the form of a solitary carbon resource in minimal media, caused the strain JA2 to exhibit altered growth rates, progressive loss of pigmentation and reduced cell size (3–4 μm), compared to malate grown cells (6–7 μm). When R. benzoatilyticus JA2 cells were grown in malate bio-anodes, they presented higher potentials (289.22 ± 4.6 mV or 436.22 OCV per mg dry weight) compared to glucose bioanodes (163 ± 5.5 mv or 188.98 OCV per mg dry weight). Insights from the metabolomic footprints and fingerprints have revealed differential regulation of key components in the central metabolic pathway such as fumarate, citrate and succinate, which are significantly increased in malate grown bio anodes. Strain JA2 cells when grown with malate as substrate are densely grown on the electrodes and exhibited reduced size, when observed under SEM, which contrasts with control cells grown on malate broth. The artificial selection pressure of the MFC and the different metabolic pathways followed by these bacteria are the reasons for such discrepancy in the power production by the strain JA2. These adaptations may indicate survival advantage during the electron transfer and growth in bio anodes. The study throws light on what types of effluents would be more suitable as substrates for R. benzoatilyticus JA2 microbial fuel cells. 相似文献
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The diesel engine generally achieves the highest fuel, energy, and thermal efficiency due to its very high compression/expansion ratio (14:1 to 25:1). Diesel engines can have a thermal efficiency that exceeds 50%. The main problem is that they emit more pollution like fine black soot particulates (C8H to C10H) and nitrogen oxides (NOX). These pollutants have been causing serious problems for human health and the global environment and also impacts on the engine. There are many types of catalysts investigated for simultaneous control of these two pollutants, i.e., platinum group metals (PGM; Pt, Pd, Rh, and Ir) based, spinel-type oxides, hydrotalcite, rare earth metal oxides, mixed transient metal oxides, etc. The high raw material cost of PGM catalysts has become a significant issue, so developing non-PGM catalysts are one of the promising challenges. There are no extra reductants required because soot catalytically oxidizes itself in the presence of NOX at a faster rate than molecular oxygen and simultaneously NOX is reduced to nitrogen. The order of oxidation potential of NOX to oxidized soot in comparison to molecular oxygen is as follows: NO2 > NO > O2. To meet the very strict EPA US 2010 and Euro VI regulations of particulate matter (PM) and NOX for heavy-duty and light-duty vehicular stringent emission, it is very important to apply the integrated catalytic systems to significantly remove PM and NOX simultaneously. Many papers related to simultaneous control of soot and NOX over different catalysts have been published but till now some of effective catalysts showing high conversion at low temperatures (possibly within the range typical of diesel exhaust: 150–450°C) have not been reviewed. Thus, this article provides a summary of published information regarding the effective catalysts, their preparation methods, properties, and application for simultaneous control of diesel soot and NOX. 相似文献
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