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1.
夏金 《机械与电子》2021,39(10):63-67
针对无人机在轨姿态控制系统误差较大的问题,提出基于干扰观测器的无人机在轨姿态控制系统设计.选择 STK53F406V 作为微处理器的芯片,存储器选用 AY54GN178M 芯片,通过 TIM 时钟输入捕获命令进行脉冲调制信号的采集与存储.系统软件采用干扰观测器来分析无人机姿态控制中的干扰频域,从干扰的种类、精度、动态性能和飞行模式等方面对系统进行正弦波的干扰分析,将扰动与系统的控制参数控制在同一个范围内,实现对飞行状态的修正和扰动频率的正确估计.实验结果表明,基于干扰观测器的无人机姿态控制系统的抗干扰性强,耗时较短,控制性能较好.  相似文献   
2.
为了解决高精度的直线时栅位移传感器依赖空间超精密刻线和刻线不均匀等问题,提出一种采用多参数协同调制的新型直线时栅位移传感器。该传感器通过在PCB基板上布置阵列的激励线圈和特定形状的感应线圈,通过调制感应的面积和线圈的参数,感应出电行波信号,经过整形后用高频时钟脉冲插补得到位移量。通过仿真分析设计与样机实验,得出实验结果表明,在不改变空间极距的情况下,使得分辨力在信号源头上提高1倍且有±68μm的测量精度。  相似文献   
3.
Heparanase (Hpse) is an endo-β-D-glucuronidase capable of cleaving heparan sulfate side chains. Its upregulated expression is implicated in tumor growth, metastasis and angiogenesis, thus making it an attractive target in cancer therapeutics. Currently, a few small molecule inhibitors have been reported to inhibit Hpse, with promising oral administration and pharmacokinetic (PK) properties. In the present study, a ligand-based pharmacophore model was generated from a dataset of well-known active small molecule Hpse inhibitors which were observed to display favorable PK properties. The compounds from the InterBioScreen database of natural (69,034) and synthetic (195,469) molecules were first filtered for their drug-likeness and the pharmacophore model was used to screen the drug-like database. The compounds acquired from screening were subjected to molecular docking with Heparanase, where two molecules used in pharmacophore generation were used as reference. From the docking analysis, 33 compounds displayed higher docking scores than the reference and favorable interactions with the catalytic residues. Complex interactions were further evaluated by molecular dynamics simulations to assess their stability over a period of 50 ns. Furthermore, the binding free energies of the 33 compounds revealed 2 natural and 2 synthetic compounds, with better binding affinities than reference molecules, and were, therefore, deemed as hits. The hit compounds presented from this in silico investigation could act as potent Heparanase inhibitors and further serve as lead scaffolds to develop compounds targeting Heparanase upregulation in cancer.  相似文献   
4.
In this study, we investigate the immunomodulatory effects of a novel antimicrobial peptide, YD1, isolated from Kimchi, in both in vitro and in vivo models. We establish that YD1 exerts its anti-inflammatory effects via up-regulation of the Nrf2 pathway, resulting in the production of HO-1, which suppresses activation of the NF-κB pathway, including the subsequent proinflammatory cytokines IL-1β, IL-6, and TNF-α. We also found that YD1 robustly suppresses nitric oxide (NO) and prostaglandin E2 (PGE2) production by down-regulating the expression of the upstream genes, iNOS and COX-2, acting as a strong antioxidant. Collectively, YD1 exhibits vigorous anti-inflammatory and antioxidant activity, presenting it as an interesting potential therapeutic agent.  相似文献   
5.
Owing to the prohibition of cosmetic animal testing, various attempts have recently been made using skin-on-a-chip (SOC) technology as a replacement for animal testing. Previously, we reported the development of a pumpless SOC capable of drug testing with a simple drive using the principle that the medium flows along the channel by gravity when the chip is tilted using a microfluidic channel. In this study, using pumpless SOC, instead of drug testing at the single-cell level, we evaluated the efficacy of α-lipoic acid (ALA), which is known as an anti-aging substance in skin equivalents, for skin tissue and epidermal structure formation. The expression of proteins and changes in genotyping were compared and evaluated. Hematoxylin and eosin staining for histological analysis showed a difference in the activity of fibroblasts in the dermis layer with respect to the presence or absence of ALA. We observed that the epidermis layer became increasingly prominent as the culture period was extended by treatment with 10 μM ALA. The expression of epidermal structural proteins of filaggrin, involucrin, keratin 10, and collagen IV increased because of the effect of ALA. Changes in the epidermis layer were noticeable after the ALA treatment. As a result of aging, damage to the skin-barrier function and structural integrity is reduced, indicating that ALA has an anti-aging effect. We performed a gene analysis of filaggrin, involucrin, keratin 10, integrin, and collagen I genes in ALA-treated human skin equivalents, which indicated an increase in filaggrin gene expression after ALA treatment. These results indicate that pumpless SOC can be used as an in vitro skin model similar to human skin, protein and gene expression can be analyzed, and it can be used for functional drug tests of cosmetic materials in the future. This technology is expected to contribute to the development of skin disease models.  相似文献   
6.
We recently discovered a novel nargenicin A1 analog, 23-demethyl 8,13-deoxynargenicin (compound 9), with potential anti-cancer and anti-angiogenic activities against human gastric adenocarcinoma (AGS) cells. To identify the key molecular targets of compound 9, that are responsible for its biological activities, the changes in proteome expression in AGS cells following compound 9 treatment were analyzed using two-dimensional gel electrophoresis (2-DE), followed by MALDI/TOF/MS. Analyses using chemical proteomics and western blotting revealed that compound 9 treatment significantly suppressed the expression of cyclophilin A (CypA), a member of the immunophilin family. Furthermore, compound 9 downregulated CD147-mediated mitogen-activated protein kinase (MAPK) signaling pathway, including c-Jun N-terminal kinase (JNK) and extracellular signal-regulated protein kinase 1/2 (ERK1/2) by inhibiting the expression of CD147, the cellular receptor of CypA. Notably, the responses of AGS cells to CypA knockdown were significantly correlated with the anticancer and antiangiogenic effects of compound 9. CypA siRNAs reduced the expression of CD147 and phosphorylation of JNK and ERK1/2. In addition, the suppressive effects of CypA siRNAs on proliferation, migration, invasion, and angiogenesis induction of AGS cells were associated with G2/M cell cycle arrest, caspase-mediated apoptosis, inhibition of MMP-9 and MMP-2 expression, inactivation of PI3K/AKT/mTOR pathway, and inhibition of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) expression. The specific interaction between compound 9 and CypA was also confirmed using the drug affinity responsive target stability (DARTS) and cellular thermal shift assay (CETSA) approaches. Moreover, in silico docking analysis revealed that the structure of compound 9 was a good fit for the cyclosporin A binding cavity of CypA. Collectively, these findings provide a novel molecular basis for compound 9-mediated suppression of gastric cancer progression through the targeting of CypA.  相似文献   
7.
8.
Ce:Y3Al5O12 transparent ceramics (TCs) with appropriate emission light proportion and high thermal stability are significant to construct white light emitting diode devices with excellent chromaticity parameters. In this work, strategies of controlling crystal-field splitting around Ce3+ ion and doping orange-red emitting ion, were adopted to fabricate Ce:(Y,Tb)3(Al,Mn)5O12 TCs via vacuum sintering technique. Notably, 85.4 % of the room-temperature luminescence intensity of the TC was retained at 150 °C, and the color rendering index was as high as 79.8. Furthermore, a 12 nm red shift and a 16.2 % increase of full width at half maximum were achieved owing to the synergistic effects of Tb3+ and Mn2+ ions. By combining TCs with a 460 nm blue chip, a warm white light with a low correlated color temperature of 4155 K was acquired. Meanwhile, the action mechanism of Tb3+ ion and the energy transfer between Ce3+ and Mn2+ ions were verified in prepared TCs.  相似文献   
9.
针对年龄变化对人脸识别率影响的问题,结合生成式对抗网络(Generative Adversarial Network,GAN)与深度特征迁移提出一种跨年龄人脸生成方法DFM-GAN(Depth Feature Migration GAN),并进行跨年龄模拟人脸验证实验研究。首先通过卷积编码器将真实样本映射到特征向量,然后利用反卷积生成器将向量投影到独热编码年龄条件下的人脸集合,通过在特征空间中迁移数据库样本人脸纹理风格、语义特点等属性,模拟生成待检人员在不同年龄段的面部图像,减少与数据库样本之间的差异性。同时通过高斯边缘模糊的方法对样本数据集做预处理,引入边缘提升对抗损失函数,使生成图像具有更为清晰的边缘,对生成图像进行局部颜色直方图匹配,增加对比度,达到提高跨年龄人脸识别性能的目的。进行了单样本不同年龄实验与指定年龄多样本实验,以人脸相似度与人脸距两项指标进行实验测量,结果表明:跨年龄数据样本经过DFM-GAN生成后的人脸图像,相似度平均提高了19.24个百分点,人脸距离平均减少了0.451,在跨年龄人脸识别方向具有较好的可行性和一定的实际意义。  相似文献   
10.
传统的UWB室内定位技术采用几何算法对标签进行解析定位,但复杂的室内环境和测距误差,可能导致方程组无解从而无法实现定位.针对上述问题,提出一种基于改进BP神经网络的UWB室内定位算法.将输出层输出的标签坐标与真实坐标的差值作为误差信号,利用梯度下降法修正网络的各个权值,使误差达到最小.以BP算法为基础,通过网络训练误差的变化趋势自适应调整学习率,提高收敛速率.通过与传统的定位技术和基于BP神经网络的定位算法进行对比实验,仿真实验结果表明,该算法的迭代次数和定位误差明显较小,输出轨迹与实际运动轨迹基本吻合,具有较高的定位精度.  相似文献   
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