Maternal Responses and Adaptive Changes to Environmental Stress via Chronic Nanomaterial Exposure: Differences in Inter and Transgenerational Interclonal Broods of Daphnia magna

There is increasing recognition that environmental nano-biological interactions in model species, and the resulting effects on progeny, are of paramount importance for nanomaterial (NM) risk assessment. In this work, Daphnia magna F0 mothers were exposed to a range of silver and titanium dioxide NMs. The key biological life history traits (survival, growth and reproduction) of the F1 intergenerations, at the first (F1B1), third (F1B3) and fifth (F1B5) broods, were investigated. Furthermore, the F1 germlines of each of the three broods were investigated over 3 more generations (up to 25 days each) in continuous or removed-from NM exposure, to identify how the length of maternal exposure affects the resulting clonal broods. Our results show how daphnids respond to NM-induced stress, and how the maternal effects show trade-offs between growth, reproduction and survivorship. The F1B1 (and following germline) had the shortest F0 maternal exposure times to the NMs, and thus were the most sensitive showing reduced size and reproductive output. The F1B3 generation had a sub-chronic maternal exposure, whereas the F1B5 generation suffered chronic maternal exposure where (in most cases) the most compensatory adaptive effects were displayed in response to the prolonged NM exposure, including enhanced neonate output and reduced gene expression. Transgenerational responses of multiple germlines showed a direct link with maternal exposure time to ‘sub-lethal’ effect concentrations of NMs (identified from standard OECDs acute toxicity tests which chronically presented as lethal) including increased survival and production of males in the F1B3 and G1B5 germlines. This information may help to fine-tune environmental risk assessments of NMs and prediction of their impacts on environmental ecology.     

Estimated genetic parameters for all genetically evaluated traits in Canadian Holsteins

Genetic improvement is a crucial tool to deal with the increasing demand for high quality, sustainably produced dairy. Breeding programs are based on genetic parameters, such as heritability and genetic correlations, for economically important traits in a population. In this study, we estimated population genetic parameters and genetic trends for 67 traits evaluated on heifers and first-lactation Canadian Holstein cows. The data consisted of approximately 500,000 records with pedigree information collected from 1980 to 2019. Genetic parameters were estimated using bivariate linear animal models under a Bayesian approach. Analyses for the 67 traits resulted in 2,211 bivariate combinations, from which the estimated genetic parameters are reported here. The most highly heritable traits were fat percent (0.66) and protein percent (0.69), followed by stature (0.47). Lowest heritabilities (0.01) were observed for disease-related traits, such as lameness and toe ulcer, and calf survival. The genetic correlations between gestation length, calf size, and calving ease measured on both heifer and cows were close to unity. On the other hand, traits such as body condition score and pin width, cystic ovaries and sole ulcer, rear teat placement, and toe ulcer were genetically unrelated. This study reports genetic parameters that have not been previously published for Canadian Holstein cows, and provides updates of those previously estimated. These estimates are useful for building new indexes, updating existing selection indexes, and for predicting correlated responses due to inclusion of novel traits in the breeding programs.     

The Iowa radon lung cancer study--phase I: Residential radon gas exposure and lung cancer

Exposure to high concentrations of radon (222Rn) progeny produces lung cancer in both underground miners and experimentally-exposed laboratory animals. The goal of the study was to determine whether or not residential radon exposure exhibits a statistically significant association with lung cancer in a state with high residential radon concentrations. A population-based, case-control epidemiologic study was conducted examining the relationship between residential radon gas exposure and lung cancer in Iowa females who occupied their current home for at least 20 years. The study included 413 incident lung cancer cases and 614 age-frequency-matched controls. Participant information was obtained by a mailed-out questionnaire with face-to-face follow-up. Radon dosimetry assessment consisted of five components: (1) on-site residential assessment survey; (2) on-site radon measurements; (3) regional outdoor radon measurements; (4) assessment of subjects' exposure when in another building; and (5) linkage of historic subject mobility with residential, outdoor, and other building radon concentrations. Histologic review was performed for 96% of the cases. Approximately 60% of the basement radon concentrations and 30% of the first floor radon concentrations of study participants' homes exceeded the US Environmental Protection Agency action level of 150 Bq m(-3) (4 pCi l(-1)). Large areas of western Iowa had outdoor radon concentrations comparable to the national average indoor value of 55 Bq m(-3) (1.5 pCi l(-1)). Excess odds of 0.24 (95% CI = -0.05-0.92) and 0.49 (95% CI = 0.03-1.84) per 11 WLM(5-19) were calculated using the continuous radon exposure estimates for all cases and live cases, respectively. Slightly higher excess odds of 0.50 (95% CI = 0.004-1.80) and 0.83 (CI = 0.11-3.34) per 11 WLM(5-19) were noted for the categorical radon exposure estimates for all cases and the live cases. A positive association between cumulative radon gas exposure and lung cancer was demonstrated using both categorical and continuous analyses. The risk estimates obtained in this study indicate that cumulative radon exposure presents an important environmental health hazard.     

The computational post buckling analysis of fuselage stiffened panels loaded in compression

Fuselage panels are commonly fabricated as skin–stringer constructions, which are permitted to locally buckle under normal flight loads. The current analysis methodologies used to determine the post buckling response behaviour of stiffened panels relies on applying simplifying assumptions with semi-empirical/empirical data. Using the finite element method and employing non-linear material and geometric analysis procedures, it is possible to model the post buckling behaviour of stiffened panels without having to place the same emphases on simplifying assumptions or empirical data. Investigation of element, mesh, idealisation, imperfection and solution procedure selection has been undertaken, with results validated against mechanical tests. The research undertaken has demonstrated that using a commercial implicit code, the finite element method can be used successfully to model the post buckling behaviour of flat riveted panels. The work has generated a series of guidelines for the non-linear computational analysis of flat riveted panels subjected to uniform axial compression.     

Effect of green manure and supplemental fertility amendments on selected soil quality parameters in an organic potato rotation in Eastern Canada

The effects of green manure, crop sequence and off-farm composts on selected soil quality parameters were assessed in a three-year organic potato (Solanum tuberosum L.) rotation in Eastern Canada. Three crop sequences varying in preceding green manure [red clover (RCl) + RCl, and beans/buckwheat or carrots + oats/peas/vetch mixture (OPV)] as main plots and four fertility treatments applied in the potato phase only [control; inorganic fertilizer; municipal solid waste compost (MSW); composted paper mill biosolid (PMB)] as subplots were compared. In 2008 and 2010, changes in selected soil quality parameters (0–15 cm) were assessed prior to planting of potatoes and at potato tuber initiation stage. Potentially mineralizable nitrogen (N) and the acid phosphatase enzyme activity average values across years were greater following RCl (1.51 abs and 622 kg ha^?1) compared with OPV (1.32 abs and 414 kg ha^?1) at potato planting. Soil NO₃–N average value was greater following RCl compared with OPV (63 vs. 52 kg ha^?1) at tuber initiation. For the other measured parameters, OPV and RCl were similar. The soil organic carbon (C) and particulate organic matter-C were greater under PMB and MSW (31.1 and 7.57 kg ha^?1) compared with fertilizer treatment (27.9 and 6.05 kg ha^?1). The microbial biomass C and microbial biomass quotient were greater under MSW (216 kg ha^?1 and 0.73 %) than PMB and fertilizer (147 kg ha^?1 and 0.50 %) across crop rotations. Annual legume green manures and off-farm composts can be used to satisfy potato N requirement and maintains soil quality in organic potato rotations.     

Divine Living: Marketing and Selling Churches as Lofts in Toronto,Canada

In recent years, a growing number of churches no longer used by religious groups have been converted to loft housing. Church lofts offer consumers heritage architecture and unique aesthetics, elements that distinguish these spaces in the housing market. In order to sell converted churches as viable homes, however, developers and their marketing teams deploy a variety of marketing strategies. Through an analysis of advertising media in Toronto, Ontario, in this paper, I show how former churches are repackaged and promoted with a heritage identity that fits a normative ideal of upscale loft living. In particular, I analyse three central marketing themes: the reinvention of a church to a house and home, the production of identity through place names and the representation of church lofts in the urban landscape. Woven together, these themes rewrite a building’s religious past and legitimize an emerging housing market that makes use of built religious heritage.     

Nine Pitfalls in Implementing Packaged Applications Software

Abstract

Users who have high expectations for a new system too often become disappointed once they discover the system does not live up to their dreams. Some IS managers circumvent this problem by purposely setting expectations too low. However, high expectations do not have to be a guarantee for disappointment and dissatisfaction.     

Test of a micromegas detector with helium-based gas mixtures for active target time projection chambers utilizing radioactive isotope beams

A Micromegas detector was tested in a helium-carbon dioxide mixture at atmospheric pressure. A stable operation of the detector was confirmed at a gain of over 10³ for a standard alpha source of ²⁴¹Am. In order to realize a position-dependent gain, an anode strip was biased while keeping the other strips at the ground potential. The gain of the biased strip was reduced by one order of magnitude without affecting the gains of the neighboring strips. The energy spectra at 3.7 MeV, the energy deposited by Am alpha particles in the sensitive region of the Micromegas, were obtained from the total charge and the charge deposit profile along the track. The energy resolutions for helium:carbon dioxide 90:10 mixture at a gas gain of about 100 were 11% FWHM for the former and 4% FWHM for the latter. The present results highlight the Micromegas as a promising electron amplifier of the forthcoming active target time projection chambers that will be dedicated to nuclear reactions with radioactive isotope beams.     

Speed and accuracy of facial expression classification in avoidant personality disorder: A preliminary study.

The aim of this preliminary study was to examine whether individuals with avoidant personality disorder (APD) could be characterized by deficits in the classification of dynamically presented facial emotional expressions. Using a community sample of adults with APD (n = 17) and non-APD controls (n = 16), speed and accuracy of facial emotional expression recognition was investigated in a task that morphs facial expressions from neutral to prototypical expressions (Multi-Morph Facial Affect Recognition Task; Blair, Colledge, Murray, & Mitchell, 2001). Results indicated that individuals with APD were significantly more likely than controls to make errors when classifying fully expressed fear. However, no differences were found between groups in the speed to correctly classify facial emotional expressions. The findings are some of the first to investigate facial emotional processing in a sample of individuals with APD and point to an underlying deficit in processing social cues that may be involved in the maintenance of APD. (PsycINFO Database Record (c) 2011 APA, all rights reserved)