The proposed system portrays the application space examination of a diverse cryptosystem processor with dynamic reconfiguration abilities. It is appropriate to a variety of signal processing application domains namely telecommunications, image processing, video coding and cryptographic processing. To differentiate between application spaces of the processor, the performance is correlated with cutting edge devices, taking ability to program, energy efficiency and computational potential as the important factors. In general the conventional method of computation is processed by means of Virtual Secure Circuit (VSC) on Advanced Encryption Standard (AES) and performance of the device Field Programmable Gate Array (FPGA) after implementation is analyzed in terms of delay and throughput. In the conventional method area overhead and power consumption are less where as the architecture lags in performance and throughput. It has been overcome through the fully parallel pipelined Architecture of the VSC on AES which outperforms the existing method in terms of performance and throughput. The energy efficiency and performance are considerably more important than processor that are used for general purpose, while still preserving a Convenient approach of programming that mainly bank on software oriented languages. The exploit of VSC based AES is to formulate the cryptographic processor held against Side Channel Attacks like attacks based on power supply and electromagnetic signals. Then the experimental result shows the promising outcomes when compared to previous methods.
Here we present the rational design and synthetic methodologies towards proteolysis-targeting chimeras (PROTACs) for the recently-emerged target leucine-rich repeat kinase 2 (LRRK2). Two highly potent, selective, brain-penetrating kinase inhibitors were selected, and their structure was appropriately modified to assemble a cereblon-targeting PROTAC. Biological data show strong kinase inhibition and the ability of the synthesized compounds to enter the cells. However, data regarding the degradation of the target protein are inconclusive. The reasons for the inefficient degradation of the target are further discussed. 相似文献
Multimedia Tools and Applications - The world of electronics in particularly in the field of image processing, numerous distinguishable and noteworthy contributions have been made available.... 相似文献
A fuzzy set based cost model for additive manufacturing is proposed. The model is illustrated through an example of selective laser sintering (SLS), a commonly used additive manufacturing (AM) process. Initially, a deterministic cost model is developed. It is then converted to a fuzzy set based model by considering uncertainty in build time estimation and cost components. For the specific case of SLS, a build time estimation procedure is developed as a part of the cost model. A method to evaluate the reliability of the cost estimate in AM and its significance is also introduced. The cost model is illustrated through two examples of products manufactured by SLS.
Wireless Networks - The power utilization has verified as a major problem in wireless sensor networks (WSNs). Many researchers have provided efficient solutions for power utilization. Clustering is... 相似文献
ABSTRACT Supply chains are becoming increasingly complex, and many companies and researchers are looking to nature for finding solutions. In this paper, we provide a narrative synthesis and systematic review to explore state-of-the-art, and identify key areas for exploration of nature inspired solutions in the supply chain area. We consider strategic, tactical, and operational decisions within supply chains and identify analogies between biological systems and supply chains to create a new research agenda. Our findings show that the majority of the research in nature inspired supply chains from the systemic perspective focuses on closed loop supply chains. In contrast, similar systemic solutions such as industrial symbiosis, circular economy, and industrial ecology have not been explored as frequently. Reducing production waste (industrial symbiosis) in addition to end-of-life product waste (closed loop supply chains), optimising raw material use and extending the life of used resources (circular economy), investigating the interactions between biosphere and technosphere (industrial ecology), and seeking solutions to industrial problems from nature (biomimicry) are all possible paths for reaching a zero-waste economy. These systemic solutions have a considerable impact on the supply chains at the strategic, tactical, and operational levels, which need to be explored to identify efficient and effective solutions. 相似文献
Objective: Innovation in material science has made it possible to fabricate a pharmaceutical material of modifiable characteristics and utility, in delivering therapeutics at a sustained/controlled rate. The objective of this study is to design and optimize the controlled release transdermal films of S-Amlodipine besylate by intercalating hydrophilic and hydrophobic polymers.
Methods: 3(2) factorial design and response surface methodology was utilized to prepare formulations by intercalating the varied concentration of polymers(A) and penetration enhancer(B) in solvent. The effect of these independent factors on drug release and flux was investigated to substantiate the ex-vivo, stability and histological findings of the study.
Results: FTIR, DSC revealed the compatibility of drug with polymers; however, the semicrystallinity in drug was observed under PXRD. SEM micrographs showed homogeneous dispersion and entanglement of drug throughout the matrix. Results from the permeation study suggested the significant effect of factors on the ex vivo permeation of drug. It was observed that drug release was found to be increased with an increase in hydrophilic polymer concentration and PE. The formulations having polymers (EC:PVPK-30) at 7:3 showed maximum drug release with highest flux (102.60?±?1.12?µg/cm2/h) and permeability coefficient (32.78?±?1.38?cm/h). Significant effect of PE on lipid and protein framework of the skin was also observed which is responsible for increased permeation. The optimized formulation was found to be stable and showed no-sign of localized reactions, indicating safety and compatibility with the skin.
Conclusion: Thus, results indicated that the prepared intercalated transdermal matrix can be a promising nonoral carrier to deliver effective amounts of drug. 相似文献
The design of a complex embedded control system involves integration of large number of components. These components need to interact in a timely fashion to achieve the system level end-to-end requirements. In practice, the component level timing specification consists of design attributes like component task mapping, task period and schedule definition but often lack details on their real-time (functional) requirements. As we observe, there is no systematic methodology in place for decomposing the feature level timing requirements into component level timing requirements. This paper proposes an early stage time-budgeting methodology to bridge the above gap. A salient proposal of this methodology is to consider parameterized component timing-requirements. A key step in the methodology involves computing a set of constraints by relating component requirements with feature requirements. This enables the separation of timing constraints from functionality decomposition, and facilitates early optimization of the component time-budget for a complex component based embedded system. This paper formalizes the proposed methodology by using Parametric Temporal Logic. A case study involving two advanced features from the automotive domain, namely Adaptive Cruise Control and Collision Mitigation is given to demonstrate the methodology. 相似文献