Impact of SARS-CoV-2 infection during pregnancy on postnatal brain development: The potential role of glial cells

Glial cells are crucial for maintaining central nervous system (CNS) homeostasis. They actively participate in immune responses, as well as form functional barriers, such as blood-brain barrier (BBB), which restrict the entry of pathogens and inflammatory mediators into the CNS. In general, viral infections during the gestational period can alter the embryonic and fetal environment, and the related inflammatory response may affect neurodevelopment and lead to behavioral dysfunction during later stage of life, as highlighted by our group for Zika virus infection. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) induces a cytokine storm and, during pregnancy, may be related to a more severe form of the coronavirus disease-19 (COVID-19) and also to higher preterm birth rates. SARS-CoV-2 can also affect the CNS by inducing neurochemical remodeling in neural cells, which can compromise neuronal plasticity and synaptic function. However, the impact of SARS-CoV-2 infection during pregnancy on postnatal CNS, including brain development during childhood and adulthood, remains undetermined. Our group has recently highlighted the impact of COVID-19 on the expression of molecular markers associated with neuropsychiatric disorders, which are strongly related to the inflammatory response. Thus, based on these relationships, we discussed the impact of SARS-CoV-2 infection either during pregnancy or in critical periods of neurodevelopment as a risk factor for neurological consequences in the offspring later in life, focusing on the potential role of glial cells. Thus, it is important to consider future and long-term public health concerns associated with SARS-CoV-2 infection during pregnancy.     

Implant surface features as key role on cell behavior

It has been recognized that physical and chemical properties of biomaterial surfaces mediate the quality of extracellular matrix (ECM) that may affect cell behaviors. In nature, ECM is a heterogeneous three-dimensional superstructure formed by three major components, glycosaminoglycan, glycoconjugate, and protein, that anchors cellular compartments in tissues and regulates the function and the behavior of cells. Changes in the biointerface alter the quality of ECM and morphology through cell surface receptors, which, in turn, enable it to trigger specific cell signaling and different cellular responses. In fact, a number of strategies have been used to improve the functionality of surfaces and direct cell behavior through precisely designed environments. Herein, we aimed to discuss, through a science-based viewpoint, the biomaterial surface features on cell behavior and analyze the impact of cell physical modification on dental implant development.     

Influence of core stiffness on the behavior of tall timber buildings subjected to wind loads

This study analyzes the feasibility of the use of cross-laminated timber (CLT) as a load-bearing structural element in a 40-story building based on Chinese design requirements. The proposed design of the high-rise concrete–CLT building utilizes the core–outrigger system. Concrete is used for the central core and outriggers, and CLT is used for the rest of the structure of the building. Finite element models with different types of connections were developed using SAP2000 to analyze the lateral behavior of the building under wind action. The finite element models with rigid connections deduce the wind load distributions on individual structural elements, which determine the total number and the stiffness of fasteners of the CLT panels. Accordingly, spring links with equivalent stiffness that simulate the mechanical fasteners were employed in SAP2000. The results indicate that CLT increases the lateral flexibility of the building. A closed concrete core was substituted by two half cores to measure the requirement of the maximum lateral deflection. However, the acceleration at the building top still exceeded the limitation prescribed in Chinese Code JGJ 3–2010 owing to the lightweight of CLT and decreased stiffness of the hybrid building. To restrict this top acceleration within the limit, further approaches to increase the stiffness in the weak direction of the building are required. Methods such as the modification of the floor layout, increase in the thickness of walls, and addition of extra damping capacity should be considered and verified in the future.     

Facile synthesis of asymmetric patchy Janus Ag/Cu particles and study of their antifungal activity

Asymmetric patchy Ag/Cu Janus nanoparticles (NPs) were synthesized via a “seed-mediated” approach. This is the first report of synthesis of nanometer sized metal-based Janus NPs without using complicated methods. Selective adsorption of the surfactant onto the seed NPs leads to the formation of Janus type structure. Subsequently the reduction potential of Ag⁺/Ag⁰ and Cu²⁺/Cu⁰ systems directs the formation of the “patch”. The patchy Janus NPs show significant antifungal activity towards a potent rice pathogen thus offering the prospect of future application in crop protection.     

Design of an Automated Sorting System for Apples Based on Single Chip Microcomputer

The grading judgment for apples is related to a variety of factors including,size,shape,color,texture,and scars.Traditional manual sorting methods are time cons...     

Effects of an escarpment on flow parameters of relevance to wind turbines

Assessing potential costs and benefits of siting wind turbines on escarpments is challenging, particularly when the upstream fetch is offshore leading to more persistent wind speeds in power producing classes, but an increased importance of stable stratification under which terrain impacts on the flow may be magnified. In part because of a lack of observational data, critical knowledge gaps remain and there is currently little consensus regarding optimal models for flow characterization and turbine design calculations. We present a unique dataset comprising measurements of flow parameters conducted over a 10–14 m escarpment at turbine relevant heights (from 9 to 200 m) and use them to evaluate model simulations. The results indicate good agreement in terms of the wind speed decrease before the terrain feature and the increase at (and downwind of) the escarpment of ~3–5% at turbine hub‐heights. However, the horizontal extent of the region, in which the impact of the escarpment on the mean flow is evident, is larger in the models than the measurements. A region of high turbulence was indicated close to the escarpment that extended through the nominal rotor plane, but the horizontal extent of this region was narrow (<10 times the escarpment height, H) in both models and observations. Moving onshore the profile of turbulence was more strongly influenced by higher roughness of a small forest. While flow angles close to the escarpment were very complex, by a distance of 10 H, flow angles were <3° and thus well within limits indicated by design standards. Copyright © 2016 John Wiley & Sons, Ltd.