首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   500955篇
  免费   12826篇
  国内免费   5118篇
电工技术   13008篇
技术理论   11篇
综合类   6756篇
化学工业   72991篇
金属工艺   21672篇
机械仪表   19585篇
建筑科学   16487篇
矿业工程   5152篇
能源动力   14331篇
轻工业   34105篇
水利工程   5924篇
石油天然气   13758篇
武器工业   707篇
无线电   61803篇
一般工业技术   94982篇
冶金工业   80282篇
原子能技术   10340篇
自动化技术   47005篇
  2022年   3952篇
  2021年   7081篇
  2020年   5863篇
  2019年   6218篇
  2018年   9227篇
  2017年   9630篇
  2016年   9238篇
  2015年   7694篇
  2014年   11556篇
  2013年   25852篇
  2012年   17619篇
  2011年   22095篇
  2010年   18118篇
  2009年   19583篇
  2008年   19926篇
  2007年   19274篇
  2006年   18196篇
  2005年   16320篇
  2004年   13966篇
  2003年   13387篇
  2002年   12135篇
  2001年   11931篇
  2000年   11212篇
  1999年   12268篇
  1998年   26517篇
  1997年   18598篇
  1996年   14443篇
  1995年   11281篇
  1994年   9757篇
  1993年   9465篇
  1992年   6902篇
  1991年   6321篇
  1990年   6172篇
  1989年   5710篇
  1988年   5317篇
  1987年   4631篇
  1986年   4420篇
  1985年   4900篇
  1984年   4461篇
  1983年   4006篇
  1982年   3677篇
  1981年   3718篇
  1980年   3432篇
  1979年   3324篇
  1978年   3320篇
  1977年   3742篇
  1976年   4859篇
  1975年   2843篇
  1974年   2640篇
  1973年   2713篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Dense pressure-sintered reaction-bonded Si3N4 (PSRBSN) ceramics were obtained by a hot-press sintering method. Precursor Si powders were prepared with Eu2O3–MgO–Y2O3 sintering additive. The addition of Eu2O3–MgO–Y2O3 was shown to promote full nitridation of the Si powder. The nitrided Si3N4 particles had an equiaxial morphology, without whisker formation, after the Si powders doped with Eu2O3–MgO–Y2O3 were nitrided at 1400 °C for 2 h. After hot pressing, the relative density, Vickers hardness, flexural strength, and fracture toughness of the PSRBSN ceramics, with 5 wt% Eu2O3 doping, were 98.3 ± 0.2%, 17.8 ± 0.8 GPa, 697.0 ± 67.0 MPa, and 7.3 ± 0.3 MPa m1/2, respectively. The thermal conductivity was 73.6 ± 0.2 W m?1 K?1, significantly higher than the counterpart without Eu2O3 doping, or with ZrO2 doping by conventional methods.  相似文献   
2.
The influence of the microstructure on the corrosion rate of three monolithic SiC samples in FLiNaK salt at 900 °C for 250 h was studied. The SiC samples, labeled as SiC-1, SiC-2, and SiC-3, had corrosion rates of 0.137, 0.020, and 0.043 mg/cm2h, respectively. Compared with grain size and the presence of special grain boundaries (i.e., Σ3), the content of high-angle grain boundaries (HAGBs) appeared to have the strongest influence on the corrosion rate of SiC in FLiNaK salt, since the corrosion rate increased six times as the concentration of high-angle grain boundaries increased from 19 to 32% for SiC-2 and SiC-1, respectively. These results stress the importance of controlling the content of HAGBs during the production process of SiC.  相似文献   
3.
Deposition of amyloid β (Aβ) fibrils in the brain is a key pathologic hallmark of Alzheimer’s disease. A class of polyphenolic biflavonoids is known to have anti-amyloidogenic effects by inhibiting aggregation of Aβ and promoting disaggregation of Aβ fibrils. In the present study, we further sought to investigate the structural basis of the Aβ disaggregating activity of biflavonoids and their interactions at the atomic level. A thioflavin T (ThT) fluorescence assay revealed that amentoflavone-type biflavonoids promote disaggregation of Aβ fibrils with varying potency due to specific structural differences. The computational analysis herein provides the first atomistic details for the mechanism of Aβ disaggregation by biflavonoids. Molecular docking analysis showed that biflavonoids preferentially bind to the aromatic-rich, partially ordered N-termini of Aβ fibril via the π–π interactions. Moreover, docking scores correlate well with the ThT EC50 values. Molecular dynamic simulations revealed that biflavonoids decrease the content of β-sheet in Aβ fibril in a structure-dependent manner. Hydrogen bond analysis further supported that the substitution of hydroxyl groups capable of hydrogen bond formation at two positions on the biflavonoid scaffold leads to significantly disaggregation of Aβ fibrils. Taken together, our data indicate that biflavonoids promote disaggregation of Aβ fibrils due to their ability to disrupt the fibril structure, suggesting biflavonoids as a lead class of compounds to develop a therapeutic agent for Alzheimer’s disease.  相似文献   
4.
The CYP74 clan cytochromes (P450) are key enzymes of oxidative metabolism of polyunsaturated fatty acids in plants, some Proteobacteria, brown and green algae, and Metazoa. The CYP74 enzymes, including the allene oxide synthases (AOSs), hydroperoxide lyases, divinyl ether synthases, and epoxyalcohol synthases (EASs) transform the fatty acid hydroperoxides to bioactive oxylipins. A novel CYP74 clan enzyme CYP440A18 of the Asian (Belcher’s) lancelet (Branchiostoma belcheri, Chordata) was biochemically characterized in the present work. The recombinant CYP440A18 enzyme was active towards all substrates used: linoleate and α-linolenate 9- and 13-hydroperoxides, as well as with eicosatetraenoate and eicosapentaenoate 15-hydroperoxides. The enzyme specifically converted α-linolenate 13-hydroperoxide (13-HPOT) to the oxiranyl carbinol (9Z,11R,12R,13S,15Z)-11-hydroxy-12,13-epoxy-9,15-octadecadienoic acid (EAS product), α-ketol, 12-oxo-13-hydroxy-9,15-octadecadienoic acid (AOS product), and cis-12-oxo-10,15-phytodienoic acid (AOS product) at a ratio of around 35:5:1. Other hydroperoxides were converted by this enzyme to the analogous products. In contrast to other substrates, the 13-HPOT and 15-HPEPE yielded higher proportions of α-ketols, as well as the small amounts of cyclopentenones, cis-12-oxo-10,15-phytodienoic acid and its higher homologue, dihomo-cis-12-oxo-3,6,10,15-phytotetraenoic acid, respectively. Thus, the CYP440A18 enzyme exhibited dual EAS/AOS activity. The obtained results allowed us to ascribe a name “B. belcheri EAS/AOS” (BbEAS/AOS) to this enzyme. BbEAS/AOS is a first CYP74 clan enzyme of Chordata species possessing AOS activity.  相似文献   
5.
The germline carrier of the BRCA1 pathogenic mutation has been well proven to confer an increased risk of breast and ovarian cancer. Despite BRCA1 biallelic pathogenic mutations being extremely rare, they have been reported to be embryonically lethal or to cause Fanconi anemia (FA). Here we describe a patient who was a 48-year-old female identified with biallelic pathogenic mutations of the BRCA1 gene, with no or very subtle FA-features. She was diagnosed with ovarian cancer and breast cancer at the ages of 43 and 44 and had a strong family history of breast and gynecological cancers.  相似文献   
6.
针对移动机器人使用超声波传感器检测环境时存在干扰与数据不确定性问题,在分析超声波传感器工作原理和相邻位置检测数据的关联特性后,提出了基于三位置超声波检测的环境轮廓构建方法,利用超声波对室内环境进行建图;再使用改进强跟踪UKF-SLAM将超声波测量数据和移动机器人驱动模型进行滤波融合,得到更准确的位姿信息与地图特征。搭建仿真环境,并通过搭载有超声波传感器的全向轮移动机器人在实验环境内验证。仿真结果表明改进方法与其他算法相比,定位和地图构建的误差降低58.058%。室内实验中,获取环境特征的平均误差降低了50.286 3%,进一步验证了提出算法的可行性与有效性。该方法对机器人同步定位与地图构建有一定参考价值。  相似文献   
7.
为了提高渐开线齿廓谐波齿轮的啮合性能,利用柔轮装配变形的包络精确算法获得了设计截面内共轭齿廓离散点,基于渐开线特征对共轭齿廓离散点拟合,得出刚轮渐开线齿廓.考虑柔轮锥度变形的影响,建立了侧隙优化控制模型,对不同径向位移下柔轮截面的变位系数进行了优化.部分柔轮截面在减小齿廓工作段高的基础上再选择合理变位系数,设计出满足空间啮合要求的渐开线齿廓谐波齿轮,并通过运动仿真分析对设计结果进行了验证.结果表明,相对于设计截面,最大径向位移增大的截面通过减小变位系数可避免干涉,最大径向位移减小的截面通过增大变位系数可获得良好啮合性能;变位系数调整量与该截面至设计截面间的距离成近似线性关系.对最大径向位移减小幅度较大而引起干涉的柔轮后端截面,需减小柔轮齿高并合理改变变位系数,才可获得良好的啮合性能.相比平面齿廓,所设计的空间齿廓能增大啮合区间和齿廓接触面积,较大幅度提升传动性能.  相似文献   
8.
为解决冲击倾向性工作面液压支架选取困难的问题,以小庄煤矿40309工作面为研究对象,采用理论计算和现场实测的方法对冲击矿压工作面液压支架选型进行研究.研究结果表明:理论计算选取的ZF14000/21/40D型液压支架可有效遏制冲击矿压的不良影响;校核结果表明选取的液压支架满足工作面回采要求;液压支架工作期间的最大工作阻力在额定工作阻力的75%以内,保证冲击倾向性工作面安全回采.  相似文献   
9.
10.
Lanthipeptides belong to the family of ribosomally synthesized and post-translationally modified peptides (RiPPs) and are subdivided into different classes based on their processing enzymes. The three-domain class IV lanthipeptide synthetases (LanL enzymes) consist of N-terminal lyase, central kinase, and C-terminal cyclase domains. While the catalytic residues of the kinase domains (mediating ATP-dependent Ser/Thr phosphorylations) and the lyase domains (carrying out subsequent phosphoserine/phosphothreonine (pSer/pThr) eliminations to yield dehydroalanine/dehydrobutyrine (Dha/Dhb) residues) have been characterized previously, such studies are missing for LanL cyclase domains. To close this gap of knowledge, this study reports on the identification and validation of the catalytic residues in the cyclase domain of the class IV lanthipeptide synthetase SgbL, which facilitate the nucleophilic attacks by Cys thiols on Dha/Dhb residues for the formation of β-thioether crosslinks.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号