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排序方式: 共有369条查询结果,搜索用时 15 毫秒
1.
Clíona Rooney Karim Hadjri Keith Mcallister Máirín Rooney Verity Faith Cathy Craig 《Journal of Housing and the Built Environment》2018,33(1):45-67
Lifetime home standards (LTHS) are a set of standards aimed at making homes more accessible. Previous research, however, indicates that LTHS do not adequately meet the needs of those with sensory impairments. Now, with visual impairment set to increase globally and acknowledging the recognised link between quality of dwelling and wellbeing, this article aims to examine the experiences of visually impaired people living in lifetime homes. The objectives are to investigate existing lifetime homes and to identify whether LTHS meet occupants’ needs. Qualitative semi-structured interviews were carried out with six visually impaired people living in homes designed to LTHS in Northern Ireland. Collected data was analysed using interpretative phenomenological analysis identifying three super-ordinate themes: (1) living with visual impairment; (2) design considerations and (3) coping strategies. A core theme of balance between psychological and physical needs emerged through interconnection of super-ordinate themes. Although there are benefits to living in lifetime homes, negative aspects are also apparent with occupants employing several coping strategies to overcome difficulties. Whilst residents experience negative emotions following visual impairment diagnoses, results suggest that occupants still regard their homes as key places of security and comfort in addition to then highlighting the need for greater consideration of specific individual needs within general guidelines. 相似文献
2.
A polymer modified with succinic anhydride has been investigated for the adsorption of cadmium (II) on a freshly precipitated aluminium (III) hydroxide floc. The proportion of chelate attached to the polymer is varied to determine the relationship between carboxyl and amino groups on the polyelectrolyte, in terms of enhanced adsorption of cadmium (II) on a hydrous aluminium floc. The presence of polyelectrolyte enhanced the adsorption of 3.3 ppm Cd (II) on a 333 ppm Al (III) floc at every concentration of polyelectrolyte investigated. The proportion of succinic anhydride attached to the polymer had an impact on the increased adsorption of Cd (II) on an Al (III) floc observed. A decreasing proportion of succinic anhydride to polymer resulted in a decrease in the amount of cadmium adsorbed on the floc. Above pH 8, a decrease in the % Cd (II) adsorbed on the floc and % Al (III) retained within the floc decreases with the presence of polyelectrolyte as a result of the formation of soluble Cd-Polyethylenimine-succinic acid (PEISA) complexes. When the Al-PEISA combination was applied to a complex matrix where Cd (II), Cu (II) and Ni (II) ions competed for adsorption, enhanced adsorption was observed for Cd (II) and Ni (II). At pH 7, dissolution of the floc observed with the addition of discrete chelates was not observed with the addition of polyelectrolytes. 相似文献
3.
Indicators of Small Town Tourism Development Potential: The Case of Fouriesburg, South Africa 总被引:1,自引:0,他引:1
As small towns experience economic and social restructuring, many are pursuing tourism opportunities as one component of a
more diversified local economic strategy. This paper is interested in the small town of Fouriesburg in South Africa's Free
State. While the town was once a thriving service center for a surrounding rural agricultural region, this traditional economy
has faded. Given that the nearby town of Clarens has developed a substantial tourism economy, we pose the question of whether
there already exist indicators that Fouriesburg may be poised for a similar change. These indicators include location within
the urban field, timing within the tourist area life cycle model, differentials/opportunities in property values, and the
role of real estate agents as “gatekeepers” in directing investments. The findings suggest that, while Fouriesburg has potential
for developing a tourism-oriented economy, many of the important policy and planning supports needed to assist with diversification
are not yet in place.
相似文献
Cathy MeiklejohnEmail: |
4.
pH‐Cleavable Nucleoside Lipids: A New Paradigm for Controlling the Stability of Lipid‐Based Delivery Systems 下载免费PDF全文
Dr. Khalid Oumzil Sébastien Benizri Giovanni Tonelli Dr. Cathy Staedel Ananda Appavoo Max Chaffanet Laurence Navailles Prof. Philippe Barthélémy 《ChemMedChem》2015,10(11):1797-1801
Lipid‐based delivery systems are an established technology with considerable clinical acceptance and several applications in human. Herein, we report the design, synthesis and evaluation of novel orthoester nucleoside lipids (ONLs) for the modulation of liposome stability. The ONLs contain head groups with 3′‐orthoester nucleoside derivatives featuring positive or negative charges. The insertion of the orthoester function in the NL structures allows the formation of pH‐sensitive liposomes. ONL‐based liposomes can be hydrolyzed to provide nontoxic products, including nucleoside derivatives and hexadecanol. To allow the release to be tunable at different hydrolysis rates, the charge of the polar head structure is modulated, and the head group can be released at a biologically relevant pH. Crucially, when ONLs are mixed with natural phosphocholine lipids (PC), the resultant liposome evolves toward the formation of a hexadecanol/PC lamellar system. Biological evaluation shows that stable nucleic acid lipid particles (SNALPs) formulated with ONLs and siRNAs can effectively enter into tumor cells and release their nucleic acid payload in response to an intracellular acidic environment. This results in a much higher antitumor activity than conventional SNALPs. The ability to use pH‐cleavable nucleolipids to control the stability of lipid‐based delivery systems represents a promising approach for the intracellular delivery of drug cargos. 相似文献
5.
A novel design of personal cooling clothing incorporating additional insulation sandwiched between phase change materials (PCMs) and clothing outer layer is proposed. Performance of four personal cooling systems including clothing with only PCMs, clothing with PCMs and insulation (PCM?+?INS), clothing with PCMs and ventilation fans (HYB), and clothing with PCMs, ventilation fans and insulation (HYB?+?INS) was investigated. Effect of additional insulation on clothing cooling performance in terms of human physiological and perceptual responses was also examined. Human trials were carried out in a hot environment (i.e. 36?°C, RH = 59%). Results showed that significantly lower mean skin/torso temperatures were registered in HYB?+?INS as compared to HYB. In contrast, no significant effect of the use of insulation on both skin and body temperatures between PCM and PCM?+?INS was observed. Also, no significant difference in thermal sensations, thermal comfort, and skin wetness sensation was registered between cooling systems with and without additional insulation.
Practitioner Summary: Hybrid personal cooling clothing has shown the ability to provide a relatively cool microclimate around the wearer’ body while working in hot environments. The present work addresses the importance of cooling energy saving for PCMs in a hot environment. This work contributes to optimising cooling performance of hybrid personal cooling systems. 相似文献
6.
7.
Stijn Dhondt Cathy Macharis Nathalie Terryn Fredriek Van Malderen Koen Putman 《Accident; analysis and prevention》2013
Statistics on road traffic accidents (RTAs) mainly come from police records. The police reported RTA statistics however are known to have a large degree of under-registration, underestimating the true risk of being injured in traffic accidents. The use of medical based datasets can provide a more accurate estimate of the actual traffic accident health risk. Exposure-based rates of the actual burden from Flanders and Brussels were calculated, comparing differences between road user, age, gender and type of injury sustained. Minimal Clinical Data (MCD) was selected for the years 2003–2007, as well as data from the mortality statistics. Disability Adjusted Life Years (DALY) were calculated and put into perspective with the passenger kilometres travelled. 相似文献
8.
The paper outlines the strategy being developed for the growth of electronic books within the UK academic community and provides a broad analysis of the e‐book industry and critical factors. The role of the JISC E‐Books Working Group is described and an overview given of its programme of activities. 相似文献
9.
Anis Akkari Cathy Guasch Michel Castagne Najoua Kamoun-Turki 《Journal of Materials Science》2011,46(19):6285-6292
Multilayers of zinc blend SnS crystalline thin film have been deposited onto glass substrates by a chemical bath deposition (CBD) method. The envelope method, based on the optical transmission spectrum taken at normal incidence, has been successfully applied to determine the layer thickness and to characterize optical properties of thin films having low surface roughness. Optical constants such as refractive index n, extinction coefficient k, as well as the real (??r) and imaginary (??i) parts of the dielectric constant were determined from transmittance spectrum using this method. Obtained low value of the extinction coefficient in the transparency domain is a good indication of film surface smoothness and homogeneity. To perform the heterojunction structure based on SnS absorber material, cubic In2S3:Al was deposited on SnO2:F/glass as window layer using CBD with different aluminum content. Optical properties of these films were evaluated. 相似文献
10.
In a proposed methodology for modeling dynamic crowd scenarios, a video corpus informs the modeling process, after which the resultant animations undergo perception-based evaluation. The aim is to improve the crowd's visual plausibility rather than the simulation's correctness. A real-life crowd animation system demonstrates the methodology's practical application. 相似文献