A thin film of cobalt selenide is deposited on the fluorescence tin oxide-coated glass surface material using a simple chemical growth technique. In this article, we report on the study of photoelectrochemical characteristics (PEC), including current–voltage, capacitance–voltage characteristics, photovoltaic power output, and spectral response in dark and light conditions. For the above parameter study, we prepared using cobalt selenide and carbon electrode (using polysulfide as electrolyte), the battery configuration is expressed as n-CoSe/NaOH (1 M)?+?Na2S (1 M)?+?S (1 M)/C (graphite). The performance of the cobalt selenide thin film material the resulted values of respective series (RS) and shunt (RSh) resistance 2.280 kΩ and 1.224 Ω, respectively. The efficiency and fill factor of these PEC cells were found to be 0.899 and 28.72%. The junction ideality value are found to be (nD) is 0.69 in the dark and 2.72 in the light (nL). The M–S plots are constructed using C?2 against applied bias voltage (with respect to SCE) for CoSe PEC cell. The positive slope of the M–S plot confirms n-type conductivity of the CoSe films. The carrier density values of the samples obtained from the M–S plots varied from 3.48?×?1014 cm?3.
A series of imidazo[2,1‐b][1,3,4]thiadiazole‐linked oxindoles composed of an A, B, C and D ring system were synthesized and investigated for anti‐proliferative activity in various human cancer cell lines; test compounds were variously substituted at rings C and D. Among them, compounds 7 ((E)‐5‐fluoro‐3‐((6‐p‐tolyl‐2‐(3,4,5‐trimethoxyphenyl)‐imidazo[2,1‐b][1,3,4]thiadiazol‐5‐yl)methylene)indolin‐2‐one), 11 ((E)‐3‐((6‐p‐tolyl‐2‐(3,4,5‐trimethoxyphenyl)imidazo[2,1‐b][1,3,4]thiadiazol‐5‐yl)methylene)indolin‐2‐one), and 15 ((E)‐6‐chloro‐3‐((6‐phenyl‐2‐(3,4,5‐trimethoxyphenyl)imidazo[2,1‐b][1,3,4]thiadiazol‐5‐yl)methylene)indolin‐2‐one) exhibited potent anti‐proliferative activity. Treatment with these three compounds resulted in accumulation of cells in G2/M phase, inhibition of tubulin assembly, and increased cyclin‐B1 protein levels. Compound 7 displayed potent cytotoxicity, with an IC50 range of 1.1–1.6 μM , and inhibited tubulin polymerization with an IC50 value (0.15 μM ) lower than that of combretastatin A‐4 (1.16 μM ). Docking studies reveal that compounds 7 and 11 bind with αAsn101, βThr179, and βCys241 in the colchicine binding site of tubulin. 相似文献
A series of benzo[b]furans was synthesized with modification at the 5‐position of the benzene ring by introducing C‐linked substituents (aryl, alkenyl, alkynyl, etc.). These compounds were evaluated for their antiproliferative activities, inhibition of tubulin polymerization, and cell‐cycle effects. Some compounds in this series displayed excellent activity in the nanomolar range against lung cancer (A549) and renal cell carcinoma (ACHN) cancer cell lines. (6‐Methoxy‐5‐((4‐methoxyphenyl)ethynyl)‐3‐methylbenzofuran‐2‐yl)(3,4,5‐trimethoxyphenyl)methanone ( 26 ) and (E)‐3‐(6‐methoxy‐3‐methyl‐2‐(1‐(3,4,5‐trimethoxyphenyl)vinyl)benzofuran‐5‐yl)prop‐2‐en‐1‐ol ( 36 ) showed significant activity in the A549 cell line, with IC50 values of 0.08 and 0.06 μM , respectively. G2/M cell‐cycle arrest and subsequent apoptosis was observed in the A549 cell line after treatment with these compounds. The most active compound in this series, 36 , also inhibited tubulin polymerization with a value similar to that of combretastatin A‐4 (1.95 and 1.86 μM , respectively). Furthermore, detailed biological studies such as Hoechst 33258 staining, DNA fragmentation and caspase‐3 assays, and western blot analyses with the pro‐apoptotic protein Bax and the anti‐apoptotic protein Bcl‐2 also suggested that these compounds induce cell death by apoptosis. Molecular docking studies indicated that compound 36 interacts and binds efficiently with the tubulin protein. 相似文献
In this present work, we have developed a novel POSS type monomer ligand “2,6-pyridinediamine-bis-(propanylheptaisobutyl POSS)” (PDC-POSS) and utilized in the preparation of potential luminescent hybrid complex Eu-PDC-POSS with an inner transition metal ion Eu3+. The solubility and photo-emitting properties of new Eu-PDC-POSS hybrid material were studied. The precursor PDC-POSS was synthesized by treating (3-aminopropyl)heptaisobutyl POSS with PDC (2,6-pyridinedicarboxylic acid chloride), and then coordinated with Eu3+ using europium nitrate to afford Eu-PDC-POSS hybrid material. The europium-doped hybrid material was characterized using fourier transform infrared spectroscopy, and scanning electron microscopy along with energy dispersive X-ray analysis. The photo emitting properties were studied using a fluorescence spectrophotometer in which, the results showed enhancement in red emission peak at 618 nm for Eu-PDC-POSS, when compared to that of a known solgel-based material Eu-PDC-solgel. 相似文献
Nanocrystalline powders of co-doped ceria oxides Ce0.85La0.10Sr0.05O2-δ (CLSO) and Ce0.85Gda0.10Sr0.05O2-δ (CGSO) have been synthesized by auto combustion method at 100°C using sucrose as fuel. Thermal analysis (TGA/DSC) of as-prepared powders indicated calcination above 400°C to remove organic residue. The average grain size of the pellets sintered at 1200°C for 4 hours is 436 and 683 nm for CLSO and CGSO, respectively. The electrical conductivity of the sintered samples was determined by impedance measurements in the temperature range 300°C to 600°C and the frequency range 20 Hz to 2 MHz. At 600°C, the total electrical conductivity (σt) of CGSO is 6.78 × 10−3 S cm−1, 2.5 times higher than 2.72 × 10−3 S cm−1 of CLSO. Further, it is found that the value of grain boundaries blocking factor (αgb) of CGSO is 0.47 which is 30% lesser than 0.68 of CLSO at 600°C. The higher value of electrical conductivity of CGSO as compared to CLSO is attributed to the lesser blocking effect of grain boundaries, smaller lattice distortion and denser microstructure of CGSO as compared to CLSO. The electrical conductivity of synthesized samples has been compared with the electrical conductivity of similar compositions of co-doped CeO2 oxides. Our study indicated that the sintering temperature, and hence, the morphology of sintered samples has a significant role in determining the electrical conductivity. The presence of oxygen vacancies in the synthesized samples is experimentally supported by using UV-visible spectroscopy, Raman spectroscopy, and thermal analysis techniques. 相似文献
Pressure dependent studies on technologically important ferroelectric material Pb0.70Ca0.30TiO3 show the occurrence of a new hitherto unreported pressure dependent phase transition around 4 GPa. In the pressure range 4–14 GPa, the parent tetragonal (P4mm) phase of Pb0.70Ca0.30TiO3 transforms in to a monoclinic (Cm) phase before attaining its paraelectric cubic (Pm3m) phase around 15 GPa. High pressure Raman studies reveal the presence of a critical pressure above which the ferroelectric phase starts to reappear in the paraelectric phase. This critical pressure is found to be much lower than the critical pressure observed in pure PbTiO3. Possible reasons for this lowering of the critical pressure are presented. 相似文献
Natural Language (NL) deliverables suffer from ambiguity, poor understandability, incompleteness, and inconsistency. Howewer,
NL is straightforward and stakeholders are familiar with it to produce their software requirements documents. This paper presents
a methodology, SOLIMVA, which aims at model-based test case generation considering NL requirements deliverables. The methodology
is supported by a tool that makes it possible to automatically translate NL requirements into Statechart models. Once the
Statecharts are derived, another tool, GTSC, is used to generate the test cases. SOLIMVA uses combinatorial designs to identify
scenarios for system and acceptance testing, and it requires that a test designer defines the application domain by means
of a dictionary. Within the dictionary there is a Semantic Translation Model in which, among other features, a word sense disambiguation method helps in the translation process. Using as a case study
a space application software product, we compared SOLIMVA with a previous manual approach developed by an expert under two
aspects: test objectives coverage and characteristics of the Executable Test Cases. In the first aspect, the SOLIMVA methodology
not only covered the test objectives associated to the expert’s scenarios but also proposed a better strategy with test objectives
clearly separated according to the directives of combinatorial designs. The Executable Test Cases derived in accordance with
the SOLIMVA methodology not only possessed similar characteristics with the expert’s Executable Test Cases but also predicted
behaviors that did not exist in the expert’s strategy. The key benefits from applying the SOLIMVA methodology/tool within
a Verification and Validation process are the ease of use and, at the same time, the support of a formal method consequently
leading to a potential acceptance of the methodology in complex software projects. 相似文献
Curcuminoids, a group of phenolic compounds isolated from the roots of Curcuma longa (Zingiberaceae), exhibit a variety of beneficial effects on health and on events that help in preventing certain diseases. A vast majority of these studies were carried out with curcumin (diferuloyl methane), which is a major curcuminoid. The most detailed studies using curcumin include anti-inflammatory, antioxidant, anticarcinogenic, antiviral, and antiinfectious activities. In addition, the wound healing and detoxifying properties of curcumin have also received considerable attention. As a result of extensive research on the therapeutic properties of curcumin, some understanding on the cellular, molecular, and biochemical mechanism of action of curcumin is emerging. These findings are summarized in this review. 相似文献
Researchers have developed many models to simulate the elasto-plastic contact of spheres. However, there does not appear to
exist a closed-form analytical model for elasto-plastic three-dimensional sinusoidal contact. This work uses a finite element
model (FEM) to characterize elasto-plastic sinusoidal contact. Although at initial contact the sphere and sinusoidal case
are very similar and can both be described by the classic elastic Hertz contact case, once the contact is pressed past a certain
range of deformation the two cases are very different. The model produces equations which can be used to approximately relate
the area of contact to the contact pressure for elasto-plastic sinusoidal contact. The equations are fit to the FEM results
and existing elastic solutions of sinusoidal contact. An empirical expression for the average pressure which causes complete
contact between elasto-plastic sinusoidal contacts is also provided. 相似文献