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1.
为解决冲击倾向性工作面液压支架选取困难的问题,以小庄煤矿40309工作面为研究对象,采用理论计算和现场实测的方法对冲击矿压工作面液压支架选型进行研究.研究结果表明:理论计算选取的ZF14000/21/40D型液压支架可有效遏制冲击矿压的不良影响;校核结果表明选取的液压支架满足工作面回采要求;液压支架工作期间的最大工作阻力在额定工作阻力的75%以内,保证冲击倾向性工作面安全回采.  相似文献   
2.
In the past decades, pyrochlores, such as Gd2Zr2O7, have demonstrated great potential to immobilize nuclear wastes such as Pu, which results in the production of Pu2Zr2O7. Due to the high radioactivity of Pu, it is difficult to investigate the radiation response behavior of Pu2Zr2O7 and its physical properties of the damaged state experimentally. Consequently, few related data have been reported in the literature thus far. In this study, first-principles calculations have been carried out to investigate the defect formation and its effect on the thermodynamic properties of Pu2Zr2O7. It reveals that PuZr antisite and O8a interstitial defects are very easy to form in Pu2Zr2O7. In particular, the O8a interstitial defect can be formed spontaneously, while it is mechanically unstable. When vacancy, interstitial or antisite defects are formed in Pu2Zr2O7, and the elastic moduli and Debye temperature are decreased. Besides, better ductility is resulted. As compared with other zirconate pyrochlores, such as Gd2Zr2O7, the Pu2Zr2O7 is suggested to be less resistant to radiation-induced amorphization. This study demonstrates that the created defects due to self-radiation from actinide decay have remarkable influences on the thermophysical properties of Pu2Zr2O7.  相似文献   
3.
Immunotherapy is an efficient approach to clinical oncology. However, the immune privilege of the central nervous system (CNS) limits the application of immunotherapeutic strategies for brain cancers, especially glioblastoma (GBM). Tumor resistance to immune checkpoint inhibitors is a further challenge in immunotherapies. To overcome the immunological tolerance of brain tumors, a novel multifunctional nanoparticle (NP) for highly efficient synergetic immunotherapy is reported. The NP contains an anti-PDL1 antibody (aPDL1), upconverting NPs, and the photosensitizer 5-ALA; the surface of the NP is conjugated with the B1R kinin ligand to facilitate transport across the blood-tumor-barrier. Upon irradiation with a 980 nm laser, 5-ALA is transformed into protoporphyrin IX, generating reactive oxygen species. Photodynamic therapy (PDT) further promotes intratumoral infiltration of cytotoxic T lymphocytes and sensitizes tumors to PDL1 blockade therapy. It is demonstrated that combining PDT and aPDL1 can effectively suppress GBM growth in mouse models. The proposed NPs provide a novel and effective strategy for boosting anti-GBM photoimmunotherapy.  相似文献   
4.
The direct-synthesis of conductive PbS quantum dot (QD) ink is facile, scalable, and low-cost, boosting the future commercialization of optoelectronics based on colloidal QDs. However, manipulating the QD matrix structures still is a challenge, which limits the corresponding QD solar cell performance. Here, for the first time a coordination-engineering strategy to finely adjust the matrix thickness around the QDs is presented, in which halogen salts are introduced into the reaction to convert the excessive insulating lead iodide into soluble iodoplumbate species. As a result, the obtained QD film exhibits shrunk insulating shells, leading to higher charge carrier transport and superior surface passivation compared to the control devices. A significantly improved power-conversion efficiency from 10.52% to 12.12% can be achieved after the matrix engineering. Therefore, the work shows high significance in promoting the practical application of directly synthesized PbS QD inks in large-area low-cost optoelectronic devices.  相似文献   
5.
Pyjamask是美国国家技术标准研究院征选后量子时代轻量级密码算法中进入第二轮的候选分组密码,对其抵抗现在流行的不可能差分分析分析为未来在实际系统中使用起到重要的作用.提出一些2.5轮不可能差分链并分析它们的结构特点和攻击效率,在一些最有效的不可能差分链的前后各接1轮和半轮,形成4轮Py-jamask多重不可能差分攻击路径.攻击结果表明Pyjamask的行混淆运算扩散性比较强,能较好地抵抗不可能差分分析,此结果是对Pyjamask安全性分析的一个重要补充.  相似文献   
6.
Shen  Aiguo  Ye  Qiubo  Yang  Guangsong  Hao  Xinyu 《Telecommunication Systems》2021,78(4):629-643
Telecommunication Systems - Machine to Machine technology has a broad application prospect in the 5G network, but there is a bottleneck in the energy consumption of intelligent devices powered by...  相似文献   
7.
Up to now, it is a major challenge to protect leading edge of the blades from solid particle erosion. Herein, we propose a structure optimization strategy to fabricate non-woven (NW) enhanced thermoplastic polyurethane nanocomposite films (thermoplastic polyurethane [TPU] - NW@G/Cx) with “sandwich - like” structure by hot pressing technology. TPU NW/graphene nanoplates/carbon nanotube (NW@G/Cx) interlayer film were first fabricated by spraying method. Then the interlayer film was laminated between TPU films to fabricate nanocomposite films. Such prepared TPU - NW@G/Cx film shows excellent solid particle erosion resistance and high-tensile strength. For example, the “steel-and-mortar” structure of NW fabric in TPU film results in high-tensile strength of 45 MPa and storage modulus of 21.2 MPa for TPU - NW@G/C1.0, increasing by 25% and 171% compared with original TPU film (35 MPa, 8 MPa), respectively. In addition, compared with pure TPU film, the “sandwich - like” structure endows TPU - NW@G/C1.2 with excellent solid particle erosion resistance and the thermal conductivity (0.251 W/m·K). These superior properties extends application of the TPU - NW@G/Cx film on wind turbine blades.  相似文献   
8.
为了实现低频振动的高灵敏度测量,设计了一种基于转动支撑梁的新型光纤布拉格光栅加速度计。 通过分析其振动 模型和 MATLAB 数值计算,优化了传感器的结构参数,设计传感器理论灵敏度为 1 725 pm / g,固有频率为 68. 4 Hz。 同时通 过 COMSOL 模拟分析传感器的动态特性,其模拟结果与理论分析吻合。 频响特性和幅值特性实验结果表明光纤光栅加速度 计在加速度 0 ~ 2 g、工作频率 0. 5 ~ 20 Hz 的范围内,传感器加速度特性曲线呈现良好线性关系,灵敏度高达 1 495. 2 pm / g,重 复性良好。 该传感器结构简单紧凑,轴承结构有效减少悬臂梁振动过程中的弹性能耗,可显著提高其灵敏度,能够实现低频 振动信号的探测。  相似文献   
9.
研究了常规铸轧过程中施加20、50和150Hz频率,电流强度为400A的脉冲电流对Al-6Zn-3Mg-2Cu合金铸轧板的组织及力学性能的影响。结果表明,经20Hz的脉冲电流处理后,Al-Zn-Mg-Cu合金铸轧板偏析情况大为改善,微观组织显著细化;150Hz脉冲电流对铸轧板的组织影响不大;铝合金中τ相广泛分布,呈网状或岛状;同时,经20Hz脉冲电流处理的铸轧板抗拉强度可达320MPa,是常规铸轧板强度的1.3倍;样品具有脆性断裂特征,脉冲处理后韧性有所提高。  相似文献   
10.
Estrogen-related receptor α (ERRα), which is overexpressed in a variety of cancers has been considered as an effective target for anticancer therapy. ERRα inverse agonists have been proven to effectively inhibit the migration and invasion of cancer cells. As few crystalline complexes have been reported, molecular dynamics (MD) simulations were carried out in this study to deepen the understanding of the interaction mechanism between inverse agonists and ERRα. The binding free energy was analyzed by the MM-GBSA method. The results show that the total binding free energy was positively correlated with the biological activity of an inverse agonist. The interaction of the inverse agonist with the hydrophobic interlayer composed of Phe328 and Phe495 had an important impact on the biological activity of inverse agonists, which was confirmed by the decomposition of energy on residues. As Glu331 flipped and formed a hydrogen bond with Arg372 in the MD simulation process, the formation of hydrogen bond interaction with Glu331 was not a necessary condition for the compound to act as an inverse agonist. These rules provide guidance for the design of new inverse agonists.  相似文献   
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