爆破位置对深凹露天矿山炮烟扩散的影响研究

深凹露天矿山由于其特殊的结构,爆破产生的炮烟扩散稀释较为困难,严重危害生产作业人员的生命安全与健康。基于实际矿山构建了深凹露天矿山的二维物理及数学模型,采用非稳态数值分析方法研究了不同爆破位置下,深凹露天矿山采坑内爆破炮烟的扩散规律。研究结果表明：不同爆破位置下,露天采坑内均出现复环流,爆破点位置是影响露天采坑内风流结构特征的重要因素；露天采坑内的炮烟最高浓度均随着时间变化而逐渐下降,但下降的速率逐步减小,呈现三个阶段的下降趋势；爆破位置位于背风侧时露天采坑内的炮烟最高浓度和降至安全浓度所需时间远高于迎风侧三个爆破位置；随着背风侧爆破点距采坑底部距离的减小,炮烟最高浓度及降至安全浓度所需时间先降低后增加,炮烟最高浓度及降至安全浓度所需时间随着迎风侧爆破位置距采坑底部距离的减小而增加。研究结果对于指导深凹露天矿山企业合理组织爆破后的生产作业和保障作业人员安全具有重要意义。     

Effects of red-wine grape pomace on the quality and sensory attributes of beef hamburger patty

This study was conducted to evaluate the effect of red-wine grape pomaces on the quality and sensory attributes of beef hamburger patties. Both phenolic content and antioxidant activity were assessed using Syrah, Merlot and Cabernet Sauvignon pomaces. Following the assessment, hamburger patties were prepared with Merlot pomace at 0%, 2% and 4% for the patty quality and sensory attributes. Grape seeds possessed significantly higher phenolics and antioxidant activities over the seedless pomace (P < 0.05), whereas no significant difference was found for phenolics and antioxidant activities within the seeds and seedless pomaces. The patty pH decreased as the pomace was added for 2% and 4%. Colour values (L*, a* and b*) of patties lowered as the pomace was added. Allo-Kramer shear force and hardness values increased while cooking yield decreased (P < 0.05) with the addition of pomace. No significant difference between control and Merlot patties was found for flavour, juiciness and colour, whereas lower sensory attributes were observed for texture, taste and overall acceptability. It is observed that the addition of fermented red-wine grape pomace provides hamburger patties with health promoting factors such as antioxidant and other functional components, but it also provided darker, sourer and lower cooking yield.     

Antioxidant and lipid-reducing effects of Rosa rugosa root extract in 3T3-L1 cell

Food Science and Biotechnology - Rosa rugosa root is traditionally known to be effective in the treatment of diabetes in Korea. R. rugosa root-specific compounds also show antioxidant effects, and...     

Surface energies in high-entropy carbides with variable carbon stoichiometry

The carbon vacancy in high-entropy carbides (HECs) has a significant impact on their physical and chemical properties, yet relevant studies have still been relatively few. In this study, we investigate the surface energies of HECs with variable carbon vacancies through first-principles calculations. The results show that the surface energy of the (1 0 0) surface of the stoichiometric HECs is significantly lower than that of (1 1 1) surface. With the decrease in carbon stoichiometry, the surface energies of both (1 0 0) and (1 1 1) surfaces increase gradually, which is mainly due to the weakening of covalent bonding and the decrease of metal Hirshfeld-I (HI) charges. However, the surface energy of (1 0 0) surface increases more quickly than that of (1 1 1) surface and will exceed that of (1 1 1) surface when the carbon stoichiometry decreases to a certain extent, which is primarily attributed to the greater decrease rate of metal HI charges of (1 0 0) surface.     

高光谱成像用高帧频CMOS图像传感器北大核心

针对高帧频、全局曝光和光谱平坦等成像应用需求,设计了一款高光谱成像用CMOS图像传感器。其光敏元采用PN型光电二极管,读出电路采用5T像素结构。采用列读出电路以及高速多通道模拟信号并行读出的设计方案来获得低像素固定图像噪声(FPN)和非均匀性抑制。芯片采用ASMC 0.35μm三层金属两层多晶硅标准CMOS工艺流片,为了抑制光电二极管的光谱干涉效应,后续进行了光谱平坦化VAE特殊工艺,并对器件的光电性能进行了测试评估。电路测试结果符合理论设计预期,成像效果良好,像素具备积分可调和全局快门功能,最终实现的像素规模为512×256,像元尺寸为30μm×30μm,最大满阱电子为400 ke^(-),FPN小于0.2%,动态范围为72 dB,帧频为450 f/s,相邻10 nm波段范围内量子效率相差小于10%,可满足高光谱成像系统对CMOS成像器件的要求。     

海洋多肽的提取纯化及生物活性研究进展

海洋生物是人类重要的食物来源，其中含有大量高质量的蛋白质。海洋多肽具有抗高血压、抗氧化、抗肿瘤等生物学功能，作为开发功能性食品和药品的来源具有巨大的潜力。本文介绍了近年来国内外利用化学水解法、酶水解法、微生物发酵法以及物理辅助提取法提取海洋多肽并采用色谱法、膜分离法将其分离纯化的相关技术，比较了它们之间的差异性，并对海洋多肽的血管紧张素转换酶（ACE）抑制活性、抗氧化活性和抗肿瘤活性等生物活性以及应用现状进行了综述。     

智能数据分区与布局研究

大数据时代,数据规模庞大,由数据进行驱动的应用分析场景日益增多.如何快速、高效地从这些海量数据中提取出用以分析决策的信息,给数据库系统带来重大挑战.同时,现代商业分析决策对分析数据的实时性要求数据库系统能够同时快速处理ACID事务和复杂的分析查询.然而,传统的数据分区粒度太粗,且不能适应动态变化的复杂分析负载;传统的数据布局单一,不能应对现代大量增加的混合事务分析应用场景.为了解决以上问题,“智能数据分区与布局”成为当前的研究热点之一,它通过数据挖掘、机器学习等技术抽取工作负载的有效特征,设计最佳的分区策略来避免扫描大量不相关的数据,指导布局结构设计以适应不同类型的工作负载.首先介绍了智能数据分区与布局的相关背景知识,然后对智能数据分区与布局技术的研究动机、发展趋势、关键技术进行详细的阐述.最后,对智能数据分区与布局技术的研究前景做出总结与展望.     

ROS-Mediated Anti-Tumor Effect of Coptidis Rhizoma against Human Hepatocellular Carcinoma Hep3B Cells and Xenografts

Coptidis Rhizoma is the dried rhizome from the Coptis chinensis Franch. that has been shown to have a number of beneficial pharmacological properties including antioxidant, anti-inflammatory, and anti-cancer effects. However, the anti-cancer effects of Coptidis Rhizoma on hepatocellular carcinoma (HCC) remain unclear. In this study, we investigated the anti-cancer properties of Coptidis Rhizoma ethanol extract (CR) in HCC Hep3B cells and in a xenograft mouse model. Our results showed that the CR significantly inhibited cell growth and induced apoptosis in Hep3B cells through increased expression of Bcl-2 associated x-protein (Bax) and cleavage of poly-ADP ribose polymerase (PARP), reduced expression of Bcl-2, and activated caspases. CR also increased the generation of intracellular reactive oxygen species (ROS), which caused a loss of mitochondrial membrane potential (MMP, ΔΨm) and activation of the mitochondria-mediated intrinsic apoptosis pathway. Moreover, N-acetylcysteine (NAC), a ROS inhibitor, markedly blocked the effects of CR on apoptotic pathways. CR also induced the expression of light chain 3 (LC3)-I/II, a key autophagy regulator, whereas CR-mediated autophagy was significantly suppressed by NAC. In addition, pre-treatment with NAC perfectly attenuated the inhibition of cell invasion and migration of CR-stimulated Hep3B cells. Furthermore, oral administration of CR suppressed Hep3B tumor growth in xenograft mice without toxicity, alterations to body weight, or changes in hematological and biochemical profiles. Taken together, our findings suggest that CR has anti-tumor effects that result from ROS generation, and may be a potential pharmacological intervention for HCC.     

Dynamic hierarchical collaborative caching scheme in ultra-dense networks

Pushing popular contents to the edge of the network can meet the growing demand for data traffic, reduce latency and relieve the pressure of the backhaul. However, considering the limited storage space of the base stations, it is impossible to cache all the contents, especially in ultra-dense network ( UDN). Furthermore, the uneven distribution of mobile users results in load imbalance among small base stations (SBSs) in both time and space, which also affects the caching strategy. To overcome these shortcoming, the impact of the changing load imbalance in UDN was investigated, and then a dynamic hierarchical collaborative caching (DHCC) scheme was proposed to optimize latency and caching hit rate. The storage of the SBS is logically divided into the independent caching layer and the collaborative caching layer. The independent caching layer caches the most popular contents for local users爷interest, and the collaborative caching layer caches contents as much as possible for the benefit of content diversity in the region. Different SBSs have respective storage space layer division ratios, according to their real-time traffic load. For SBSs with heavy load, the independent caching layers are allocated with more space. Otherwise, the collaborative caching layers could store more contents with larger space. The simulation results show that, DHCC improved both transmission latency and hit rate compared with existing caching schemes.