The time course of spoken word learning and recognition: Studies with artificial lexicons.

The time course of spoken word recognition depends largely on the frequencies of a word and its competitors, or neighbors (similar-sounding words). However, variability in natural lexicons makes systematic analysis of frequency and neighbor similarity difficult. Artificial lexicons were used to achieve precise control over word frequency and phonological similarity. Eye tracking provided time course measures of lexical activation and competition (during spoken instructions to perform visually guided tasks) both during and after word learning, as a function of word frequency, neighbor type, and neighbor frequency. Apparent shifts from holistic to incremental competitor effects were observed in adults and neural network simulations, suggesting such shifts reflect general properties of learning rather than changes in the nature of lexical representations. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Diagnostic value of myocardial thallium stress scintigraphy in the detection of coronary artery disease in patients undergoing chronic hemodialysis

Atherosclerotic heart disease is the leading cause of death in patients with end stage renal disease, but its non invasive detection remains difficult because of a low efficacy of exercise testing. The aim of the study was to evaluate diagnostic accuracy of thallium myocardial imaging after dipyridamole combined with exercise. Forty two chronic dialysis patients (34 men, 8 women) aged 55 +/- 11 years (range: 36 to 75) without symptom of angina nor myocardial infarction were studied. In each patient, an echocardiography, a myocardial scintigraphy with dipyridamole combined with symptom-limited exercise, and coronarography were performed. A coronary heart disease was diagnosed by coronarography in 10 patients (4.5 and 1 respectively with 1, 2 and 3 vessels diseased). Echocardiography detected a left ventricular hypertrophy (LVH) in 26 patients and a regional asynergia in 14 patients. A positive scintigraphy was present in 11 patients. Three false-positive and 2 false-negative on scintigraphy were noted. Sensibility, specificity, positive predictive value and negative predictive value were respectively evaluated at 80, 73, 73 and 93%. All the five patients with either false-positive or false-negative scintigraphy exhibited a LVH. CONCLUSION. In chronic dialysis patients, coronary heart disease may be detected by thallium myocardial imaging after dipyridamole combined with exercise.     

嵌入式超长指令语音压缩处理器的VLSI实现

介绍了一款语音压缩专用处理器的设计思路，使用嵌入式FLASH超长指令字系统有效的提高了芯片的处理能力，同时将增强型算术逻辑单元、乘法器、乘累加器结合在一起，在改进的哈佛体系结构上实现了微控制器与DSP的单核设计。使用存储器操作指示寄存器、分层寄存器组，能够简化子程序调用方式。该微处理器采用0．25μm CMOS工艺实现，芯片面积为25mm^2。仿真结果表明，在20MHz工作频率下，芯片处理能力与50MIPS的通用DSP相当，同时能够保持原有编码质量。该处理器能够实现多种类型的语音压缩算法，可以达到对语音算法的高保密性、低复杂度、易开发性。     

双级液体去湿冷却空调性能分析

本文介绍了双级液体去湿冷却空调系统的工作原理,分析了系统的吸湿和再生性能、热损失及火用效率.较单级系统而言,双级空调系统具有良好的整体性能与节能效益,在使用低温热源上有较大优势.     

面向三维CAD模型的加权谱聚类算法研究

局部区域特征的重要程度对三维CAD模型的分类有很大影响.针对现有聚类算法未能有效利用此关键特征实现聚类,提出一种基于局部区域的加权谱聚类算法.该算法按局部区域在模型库中出现的频次计算权重,提高出现频次低但区分能力强的局部区域的重要程度,从而降低常见局部区域的重要程度;并将上述表达与严重依赖模型间相似度的加权谱聚类算法相结合作为权重信息.实验结果显示,该方法能较好地完成三维CAD模型聚类任务,最终得到的NMI值、V-measure值对比当前最优方法所得结果分别提高3％、4％.     

What is it? Bronchiolo-alveolar carcinoma with a cavitated multinodular appearance

OBJECTIVE: To report a suspected case of isoniazid-induced psychosis in a 31-year-old woman. CASE SUMMARY: A 31-year-old white woman without a prior psychiatric history presented with psychotic symptoms suspected to be related to prophylactic treatment with isoniazid after she tested positive to a tuberculin (purified protein derivative) test. The psychotic symptoms resolved partially after isoniazid was discontinued and completely after treatment with olanzapine was begun. The patient remained symptom-free 11 months after discharge from the hospital. DISCUSSION: Cases of isoniazid-related psychiatric disorders reported in the literature include psychosis, obsessive-compulsive neurosis, and mania. With the increasing prevalence of tuberculosis in the US, more people are expected to receive treatment for tuberculosis. Pyridoxine deficiency may play a role in the pathogenesis of isoniazid-induced psychosis. Such deficiency states may be detected indirectly by measuring urinary metabolites of tryptophan. CONCLUSIONS: Clinicians should be aware of this adverse effect of isoniazid and that it may present with a broad clinical picture.     

Occlusal and functional evaluations in adults: a case report

Completely different entities might be with the same possibility in the baseline of interweaving of symptoms and signs of nervous system damage. One of them, the deficiency of vitamin B12 very frequently causes megaloblastic anemia and funicular myelosis. In the case of our patient, after the clinical picture of hemolytic anemia was revealed, by slow-progressive course was developed neurologic deficiency that, according to its features, could have the deficiency of cobalamin and folic acid in its etiologic background. On the basis of disease course, clinical finding, numerous clinical investigations so as the reaction to applied therapy it was assumed that the patient had besides confirmed autoimmune hemolytic anemia the pernicious anemia as the associated cause of anemic syndrome and the basic reason of the development of neurologic deficiency. Described is the frequent associated occurrence of pernicious anemia and antiglobulin positive hemolytic anemia, so as the significant association of pernicious anemia with the deficiency of immunoglobulins that was otherwise observed in our patient as the permanent IgA deficiency.     

gp25L/emp24/p24 protein family members of the cis-Golgi network bind both COP I and II coatomer

Abstract. Five mammalian members of the gp25L/ emp24/p24 family have been identified as major constituents of the cis-Golgi network of rat liver and HeLa cells. Two of these were also found in membranes of higher density (corresponding to the ER), and this correlated with their ability to bind COP I in vitro. This binding was mediated by a K(X)KXX-like retrieval motif present in the cytoplasmic domain of these two members. A second motif, double phenylalanine (FF), present in the cytoplasmic domain of all five members, was shown to participate in the binding of Sec23 (COP II). This motif is part of a larger one, similar to the F/YXXXXF/Y strong endocytosis and putative AP2 binding motif. In vivo mutational analysis confirmed the roles of both motifs so that when COP I binding was expected to be impaired, cell surface expression was observed, whereas mutation of the Sec23 binding motif resulted in a redistribution to the ER. Surprisingly, upon expression of mutated members, steady-state distribution of unmutated ones shifted as well, presumably as a consequence of their observed oligomeric properties.     

Penny-shaped crack in a transversely isotropic solid

An analytical solution is given for the displacement and stress distribution produced in the interior of a transversely isotropie solid containing a penny-shaped crack situated in an elastic symmetry plane and axially-loaded. Curves of numerical results are presented for the stress intensity factor and the normal displacement. They show the influence of this type of anisotropy.     

Effects of aging on left ventricle-arterial coupling in man

Twenty-five normotensive men without any cardiac or arterial pathology, aged 22 to 68 years, 12 less than 45 year old, 13 over 45 years, underwent cardiac catheterisation and angiography. The following parameters were calculated: 1) a global index of arterial function (Ea) and its determining factors (Ea = LVESP/SV where LEVSP = left ventricular end systolic pressure and SV = left ventricular stroke volume); Ea = (HR x SVR) + Ea' where HR = heart rate, SVR = total systemic vascular resistance and Ea' = (LVESP - MAP/SV) (MAP = mean arterial pressure); 2) an index of global left ventricular pump function: ELV (ELV = LVESP/LVESV, where LVEDV = left ventricular end systolic volume; 3) an index of LV-arterial coupling: the Ea/ELV ratio. With aging, both Ea (by increase in SVR) and Ea' and ELV increased significantly. Ea/ELV (inverse of the ejection fraction-1) increased with age but ELV less than Ea. Ea/ELV was significantly higher in patients over 45 years of age but the correlation between ejection fraction and age was not statistically significant (p = 0.10). These results suggest that with aging, the improvement in LV pump function approximately corresponds to the degradation in arterial transport function: the left ventricular-arterial coupling as assessed by the Ea/ELV ratio (and therefore the ejection fraction) is maintained in the majority of cases.