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1.
Karim Gharbi Louise Matthews James Bron Ron Roberts Alan Tinch Michael Stear 《Journal of the Royal Society Interface》2015,12(110)
Sea lice threaten the welfare of farmed Atlantic salmon and the sustainability of fish farming across the world. Chemical treatments are the major method of control but drug resistance means that alternatives are urgently needed. Selective breeding can be a cheap and effective alternative. Here, we combine experimental trials and diagnostics to provide a practical protocol for quantifying resistance to sea lice. We then combined quantitative genetics with epidemiological modelling to make the first prediction of the response to selection, quantified in terms of reduced need for chemical treatments. We infected over 1400 young fish with Lepeophtheirus salmonis, the most important species in the Northern Hemisphere. Mechanisms of resistance were expressed early in infection. Consequently, the number of lice per fish and the ranking of families were very similar at 7 and 17 days post infection, providing a stable window for assessing susceptibility to infection. The heritability of lice numbers within this time window was moderately high at 0.3, confirming that selective breeding is viable. We combined an epidemiological model of sea lice infection and control on a salmon farm with genetic variation in susceptibility among individuals. We simulated 10 generations of selective breeding and examined the frequency of treatments needed to control infection. Our model predicted that substantially fewer chemical treatments are needed to control lice outbreaks in selected populations and chemical treatment could be unnecessary after 10 generations of selection. Selective breeding for sea lice resistance should reduce the impact of sea lice on fish health and thus substantially improve the sustainability of Atlantic salmon production. 相似文献
2.
Courteville A. Gharbi T. Cornu J.Y. 《IEEE transactions on bio-medical engineering》1998,45(2):145-150
A high-sensitivity human muscle-vibration measurement (MMG) sensor adapted to clinical use is presented. The muscle vibration phenomenon is modeled and investigated to optimize the measurement technique. The sensor uses an acoustic impedance adaptation technique to convert the skin surface vibration in terms of acoustic pressure, which is sensed by a microphone. The device is calibrated and gives the real amplitude of the vibration. It is also well fitted to measure other physiological vibrations in the 2 Hz-1 kHz range 相似文献
3.
Brella M. Taabouche A. Gharbi B. Gheriani R. Bouachiba Y. Bouabellou A. Serrar H. Touil S. Laggoune K. Boudissa M. 《Semiconductors》2022,56(3):234-239
Semiconductors - In this work, TiO2 thin films were deposited onto glass substrate by two different techniques: sol–gel dip-coating (SG) and reactive DC magnetron sputtering (Sput). The... 相似文献
4.
The influence of polyesters end-groups on cyclic oligoester formation is investigated using a series of hydroxy-, carboxy- and methylester-terminated aliphatic polyesters, in the presence of various ester interchange catalysts. The presence of hydroxy end-groups is the preponderant factor on cyclodepolymerization kinetics. This indicates that the main reaction is the intramolecular hydroxy–ester interchange reaction between hydroxy end-groups and ester functions in the chain. Carboxy-ester and ester–ester interchanges play a minor role, as the cycle-chain equilibrium is reached only very slowly when carboxy- or ester-terminated polyesters are reacted. High temperature and the presence of tin catalysts are also favorable factors, while, as expected, dilution shifts the equilibrium toward the formation of high yields of cyclic oligoesters. A mechanism is proposed, based on the reverse of the “coordination-insertion” mechanism established for the ring-opening polymerization of lactones. 相似文献
5.
The effect of heat-treatment on foaming properties of ostrich albumen was investigated. At pH 7.5, coagulation of ovotransferrin (OT) resulted in minimum foaming capacity (FC) and maximum foam density (FD). While both exposure of sulfhydryl groups of ovalbumin (OV) and OT-OV interactions improved FC at lower pH, neither of them had beneficial effect on FC at pH 9. At pH 9, FC and FD were mildly affected by heat-treatment because of less aggregation of OT, then FC decreased due to covalent aggregates composed of ovomucin and OV, but at higher temperatures, higher level of OV unfolding resulted in enhanced FC. 相似文献
6.
We introduced recently phase measurements usually performed in interferometry to the domain of image processing and intelligent vision [IEEE Trans. Instrum. Meas. 49, 867 (2000)]. Our purpose is to sense with a high accuracy the position, orientation, and displacement of two-dimensional (2D) surfaces observed by a static vision system. We report on significant improvements of the method. Experimental measurements reveal a peak-valley noise of approximately 10(-2) CCD pixel, corresponding approximately to a 10(-3) period of the phase reference pattern. Then the observation of 10 microm scaled features enables an accuracy of a few nm in the position sensing of the phase reference pattern for the extended 2D measurement range. 相似文献
7.
Maintenance scheduling and production control of multiple-machine manufacturing systems 总被引:5,自引:0,他引:5
This paper deals with the production and preventive maintenance control problem for a multiple-machine manufacturing system. The objective of such a problem is to find the production and preventive maintenance rates for the machines so as to minimize the total cost of inventory/backlog, repair and preventive maintenance. A two-level hierarchical control model is presented, and the structure of the control policy for both identical and non-identical manufacturing systems is described using parameters, referred to here as input factors. By combining analytical formalism with simulation-based statistical tools such as experimental design and response surface methodology, an approximation of the optimal control policies and values of input factors are determined. The results obtained extend those available in existing literature to cover non-identical machine manufacturing systems. A numerical example and a sensitivity analysis are presented in order to illustrate the robustness of the proposed approach. The extension of the proposed production and preventive maintenance policies to cover large systems (multiple machines, multiple products) is discussed. 相似文献
8.
Mohamed Haouari Anis Gharbi Mahdi Jemmali 《International Transactions in Operational Research》2006,13(6):529-548
We address the problem of minimizing makespan on identical parallel machines. We propose new lower bounding strategies and heuristics for this fundamental scheduling problem. The lower bounds are based on the so‐called lifting procedure. In addition, two optimization‐based heuristics are proposed. These heuristics require iteratively solving a subset‐sum problem. We present the results of computational experiments that provide strong evidence that the new proposed lower and upper bounds consistently outperform the best bounds from the literature. 相似文献
9.
We consider retrial queueing systems, in which an arriving customer finding the server busy, may repeat his call after a random duration. The consideration of repeated calls introduces great analytical difficulties. In fact, detailed analytical results exist for some special retrial queueing systems, while for many others, the performance evaluation is limited to numerical algorithms, approximation methods and simulation. Retrial queues have been widely used to model many problems in telephone switching systems, telecommunication and computer networks. In this paper, we show a method of modelling and analysing retrial queueing systems, using the Generalized Stochastic Petri nets (GSPNs). 相似文献
10.