Temperature/pH/magnetic triple‐sensitive nanogel–hydrogel nanocomposite for release of anticancer drug

Hydrogels, nanogels and nanocomposites show increasing potential for application in drug delivery systems due to their good chemical and physical properties. Therefore, we were encouraged to combine them to produce a new compound with unique properties for a long‐term drug release system. In this regard, the design and application of a nanocomposite hydrogel containing entrapped nanogel for drug delivery are demonstrated. To this aim, we first prepared an iron oxide nanocomposite nanogel based on poly(N‐isopropylacrylamide)‐co‐((2‐dimethylaminoethyl) methacrylate) (PNIPAM‐co‐PDMA) grafted onto sodium alginate (NaAlg) as a biocompatible polymer and iron oxide nanoparticles (ION) as nanometric base (PND/ION‐NG). This was then added into a solution of PDMA grafted onto NaAlg. Through dropwise addition of mixed aqueous solution of iron salts into the prepared polymeric solution, a novel hydrogel nanocomposite with excellent pH, thermal and magnetic responsivity was fabricated. The synthesized samples were fully characterized using Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy with energy‐dispersive X‐ray analysis, vibrating sample magnetometry and atomic force microscopy. A mechanism for the formation of PNIPAM‐co‐PDMA/NaAlg‐ION nanogel–PDMA/NaAlg‐ION hydrogel and PND/ION nanogel is suggested. Swelling capacity was measured at various temperatures (25 to 45 °C), pH values (from 2 to 11) and magnetic field and under load (0.3 psi) and the dependence of swelling properties of the nanogel–hydrogel nanocomposite on these factors was well demonstrated. The release rate of doxorubicin hydrochloride (DOX) as an anticancer drug was studied at different pH values and temperatures in the presence and absence of a magnetic field. The results showed that these factors have a high impact on drug release from this nanocomposite. The result showed that DOX release could be sustained for up to 12.5 days from these nanocomposite hydrogels, significantly longer than that achievable using the constituent hydrogel or nanogel alone (<1 day). The results indicated that the nanogel–hydrogel nanocomposite can serve as a novel nanocarrier for anticancer drug delivery. © 2019 Society of Chemical Industry     

Characterization of the Ion Beam Current Density of the RF Ion Source with Flat and Convex Extraction Systems

Silicon - The characterization of ion beam current density distribution and beam uniformity is crucial for improving broad-beam ion source technologies. The design of the broad ion beam extraction...     

Multi expression programming: a new approach to formulation of soil classification

This paper presents an alternative approach to formulation of soil classification by means of a promising variant of genetic programming (GP), namely multi expression programming (MEP). Properties of soil, namely plastic limit, liquid limit, color of soil, percentages of gravel, sand, and fine-grained particles are used as input variables to predict the classification of soils. The models are developed using a reliable database obtained from the previously published literature. The results demonstrate that the MEP-based formulas are able to predict the target values to high degree of accuracy. The MEP-based formulation results are found to be more accurate compared with numerical and analytical results obtained by other researchers.     

Adaptive Control for State Synchronization of Nonlinear Haptic Telerobotic Systems with Asymmetric Varying Time Delays

In this paper, we introduce a new adaptive controller design scheme for nonlinear telerobotic systems with varying time delays where the delays and their variation rates are unknown. The designed controller has the ability to synchronize the state behaviors of the local and the remote robots. In this paper, asymptotic stability in the presence of varying time delays is of interest. Using the proposed controller, asymptotic stability of the bilateral telerobotic system subject to any bounded yet unknown varying delay with a bounded yet unknown rate of change can be guaranteed. Besides the varying time delay, the proposed adaptive controller has the ability to adapt to the parameter variations in the local and the remote robots’ dynamics. It is shown that position and velocity errors between the local and the remote manipulators converge to the zero asymptotically, thus ensuring teleoperation transparency. Experimental and simulation results with a pair of PHANToM haptic devices and a pair of planar manipulators under varying time delays in the communication channel demonstrate the effectiveness of the proposed scheme.     

Estimating the scattering distribution of the received signals in multipath fading channels

This paper presents a novel approach for estimating the distribution of the incoming waves at the mobile unit antenna, i.e. the scattering distribution, in a typical micro-cellular system. This estimate is vital in determining many system parameters of interest as well as designing unbiased estimators for the velocity of mobile units in micro-cellular systems. The proposed approach deploys the zero-crossing rates of the quadrature components and the instantaneous frequency of the received signal at the mobile unit to estimate the scattering distribution. We also propose a new model for simulating multipath fading channels with non-isotropic scattering. We use the channel simulator to evaluate the performance of the proposed estimator for the scattering distribution. Simulation results show that proposed estimator exhibits small bias and root mean square error.     

Rapid Synthesis of Cobalt Metal Organic Framework

Metal-organic framework (MOF) has been shown to potential applications due to the high porous hybrid structure. Cobalt MOF was synthesized rapidly by ultrasound energy with about 3,000 m²/g surface area by BET method. Furthermore, this component is crystalline with significant thermal stability, on account of X-ray diffraction and thermal analysis, respectively. Based on high roughness, crystallinity, and unreported type of FTIR spectrum, a new structure of Co-MOF structure was proposed.     

Removal of melanoidin from molasses spent wash using fly ash-clay adsorbents

Removal of melanoidin pigment from molasses spent wash was investigated using a new adsorbent. Solid adsorbents were fabricated from charcoal fly ash and clay. The effect of various molasses concentration (6 to 12 g/l) on removal efficiency was studied. The obtained results revealed that maximum removal efficiency of 82% was achieved at the molasses concentration of 6 g/l and contact time of 7 h. The saturated porous adsorbents were regenerated and reused to conduct similar experiments. The achieved data showed that more than 90% of the capacity of the fresh adsorbent was recovered after regeneration. Various adsorption isotherms of Langmuir, Freundlich, Temkin and Harkins-Jura were applied to interpret the obtained experimental data. The obtained results revealed that the sorption data were well described by the Harkins-Jura model. Also, various kinetic models of pseudo-first order, pseudo-second order, Elovich and intra-particle diffusion were used to predict the characteristic parameters which are useful in process design. It was concluded that the best fit was obtained with pseudo-second order kinetic model at low molasses concentrations.     

Antecedents of behavioural commitment in inter-organizational relationships: a field study of the UK construction industry

Commitment is vital in inter-organizational relationships. It is important to understand what drives commitment which then affects the relationship between organizations. Commitment is a multidimensional construct and its dimensions can be broadly categorized into attitudinal and behavioural perspectives. In conventional practice, commitment researchers have tended to focus on the attitudinal perspective, while the behavioural perspective is largely ignored. In an attempt to buck that conventional trend commitment research is proposed along the unconventional but widely accepted as important behavioural perspective, building up a more complete understanding of the importance of behavioural commitment, as well as developing and validating a theoretical model that depicts precisely the relationship between behavioural commitment and its key driving factors. Accordingly a large-scale questionnaire survey has been conducted in the UK construction industry and 636 responses were collected. Structural equation modelling was then used to test the theoretical model. Results validate trust, reliance and dependence as the major antecedents of behavioural commitment. A new direction in commitment research adds new findings to the current body of commitment literature.     

Effect of modified single‐wall carbon nanotubes on mechanical and morphological properties of thermoplastic elastomer nanocomposites based on (polyamide 6)/(acrylonitrile butadiene rubber)

Thermoplastic elastomer nanocomposites based on acrylonitrile butadiene rubber (NBR) and polyamide 6 (PA6), with acid functionalized single‐wall carbon nanotubes (SWNT), were prepared via a direct melt‐mixing process in an internal mixer. The influence of SWNT content (0, 0.5, 1, 1.5) on morphological properties of PA6/NBR with different ratios (80/20, 70/30, 60/40) were then investigated. Characterization of nanocomposites was conducted by using transmission electron microscopy, scanning electron microscopy, differential scanning calorimetry, and mechanical properties. Scanning electron microscopy micrographs proved the droplet‐matrix blend morphology in which the size of NBR droplets decreased as the SWNT loading increased, suggesting dispersion of SWNT in the PA6 phase. It was further proved by transmission electron microscopy images, showing homogenous dispersion of SWNT in the PA6 phase. Differential scanning calorimetry results showed a slightly reduced percentage of crystallinity in samples containing SWNT. The mechanical properties of nanocomposites indicated an enhancement in tensile strength, modulus, and hardness on increasing SWNT content. J. VINYL ADDIT. TECHNOL., 22:336–341, 2016. © 2014 Society of Plastics Engineers