Synchronous amplification of subpicosecond pulses

In high-gain dye amplifiers, the effective storage time of the gain medium is only a few hundred picoseconds. Therefore, efficient amplification of ultrashort pulses places a stringent requirement on the synchronization between the pump pulse and the pulse to be amplified. We present a technique of short pulse generation using a dye laser synchronously pumped by a frequency-doubled CW mode locked Nd:YAG laser. Pulses as short as 70 fs are produced. The short optical pulses are subsequently amplified with two different synchronous amplification schemes using 100 ps pulses to establish the gain in the dye amplifier stages. Subpicosecond pulses with energies from a few hundred nanojoules at 500 Hz to a few hundred microjoules at 7 Hz can be obtained.     

The german precursor study—methodology and insights

Probabilistic Safety Assessment (PSA) yields a systematic and quantitative prediction of possible accident scenarios at technical installations on the basis of data gained from the past experience on similar technical installations. Precursor studies are performed in order to make operational experience, as far as possible, available for support of PSAs. An Accident Sequence Precursor in a Nuclear Power Plant (NPP) is defined as an observed event scenario which could result, in coincidence with additional postulated events, in a potential severe core damage accident. In this paper, the methodology and the insights of the plant-specific German Precursor Study are explained in detail. As the results have demonstrated, the Precursor methodology is applicable for ranking of the safety significance of the observed events and for trending the plant risk level (described by the frequency of potential severe core damage accidents) versus operating time.     

Efficiency of some novel carbon black/rubber coupling agents

The effect of some new synthesized carbon black/rubber coupling agents without nitrosogroups have been investigated in comparison with one commercially available coupling agent N, N′-bis(2-methyl-2-nitropropyl)-1,6-diaminohexane (Sumifine^TM 1162). Rubber compounds based on natural rubber and carbon black N-220 were used for these experiments. Tensile properties, impact resilience, and heat buildup of vulcanized rubber are improved with all coupling agents under investigation in comparison with the unmodified compound. Any positive effect of coupling agents appears also in tear resistance, dynamic flow, and permanent set. The correlation between the efficiency and chemical structure of coupling agents is discussed. © 1996 John Wiley & Sons, Inc.     

Important issues using PSA technology for design of new systems and plants

Modern engineering design of new systems or plants needs not only the specification of the function of the system during various life cycle periods, but also the consideration of additional requirements and the demonstration of the compliance with it based on a predictive model considering measurable properties and possible malfunctions of the system parts. Additional requirements can be high availability, low emissions or high safety level. PSA technology provides a framework and tools to establish design targets and to demonstrate their compliance. In this paper important issues using this technology are discussed. Issues are targeted at various levels—the basic evaluation of reliability for active and passive components and the entire system, the general process to show the compliance of the given system characteristics with the characteristics required. This paper does not deal with the details of all these issues, but provides references for further information.     

Synthesis and structure-activity relationship of the isoindolinyl benzisoxazolpiperidines as potent,selective, and orally active human dopamine D4 receptor antagonists

A new class of potent dopamine D(4) antagonists was discovered with selectivity over dopamine D(2) and the alpha-1 adrenoceptor. The lead compound was discovered by screening our compound collection. The structure-activity relationships of substituted isoindoline rings and the chirality about the hydroxymethyl side chain were explored. The isoindoline analogues showed modest differences in potency and selectivity. The S enantiomer proved to be the more potent enantiomer at the D(4) receptor. Several analogues with greater than 100-fold selectivity for D(4) over D(2) and the alpha-1 adrenoreceptor were discovered. Several selective analogues were active in vivo upon oral or intraperitoneal administration. A chiral synthesis starting from either D- or L-O-benzylserine is also described.     

Interventions for coronary stenosis--a Canadian experience of 30 revolutionary years

OBJECTIVE: To report 2324 coronary stenosis interventions (Vineberg procedures [VbP], coronary artery bypass graft operations [CABG] and percutaneous transluminal coronary angioplasties [PTCA]), in 1711 patients of a Canadian military hospital between 1965 and 1995 and to report their evolution and interaction in a historical context. DESIGN: Retrospective examination of clinical and angiographic findings in hard records, collected from the beginning for long term follow-up and later embedded in a custom-designed computer database. PATIENTS: Most were male, mean ages 43.2 and 43.3 years for first and second VbPs; 48.9 and 58.2 years for first and repeat CABGs; and 53.4 and 59.9 years for first and repeat PTCAs, respectively; 12% of all patients were 39 years old or younger at the first intervention. INTERVENTIONS: There were 160 VbPs, 1637 CABGs and 527 PTCAs. Of 1711 subjects, 74% had only one procedure, 15% had more than one of the same kind, and 11% had more than one of different kinds. MAIN RESULTS: Perioperative mortality for VbPs was 4.4%; for 'isolated' first CABGs it was 1.4% and 6.6% for reoperations, when other concurrent major cardiac procedures, excepting ventricular aneurysm repair, were excluded. It was 0.4% for PTCAs. Perioperative mortality for all 1761 'isolated' coronary interventions necessitating thoracotomy, during 30 years, was 2.4%. Angiographic follow-up rates were high and some findings are reported, including early postoperative patency rates for 5065 coronary bypass grafts, and long term follow-up data on graft patency and disease. CONCLUSIONS: Each intervention was used to circumvent or relieve coronary stenosis, in the early years when it became available and, later, as was most appropriate for dealing with specific clinical problems. The impact of advances in the evolution of these interventions on therapeutic decision-making is discussed. Finally, tributes are paid to those responsible for making these procedures possible, including a Canadian surgeon whose role was pivotal.     

Treatment of uncertainties in reliability models

For systems in Nuclear Installations it is necessary to analyze the possible mechanisms for failure of each component, to perform probabilistic analysis for the expected rate of such failure and to aggregate the component failure logically and numerically to a prediction of the reliability of the whole system. In this process we must treat models and data associated with uncertainties of different kinds. Also subjective judgements are necessary for an estimation of these uncertainties in the models and data. Based on a system example this paper illustrates some of these aspects more detailed.