Small-Signal Dynamic Analysis of Regulated Class E DC/DC Converters

Class E dc/dc converters can operate at high switching frequencies with very low switching power losses. Using commercially available power transistors and diodes, Class E converters can operate at switching frequencies in the low-MHz range, with efficiencies of about 85 percent. Previous papers dealt with the circuit parameter values needed to obtain high-efficiency operation and output-voltage regulation, and with the static control characteristics of the Class E dc/dc converter cell. The analysis is extended to include the dynamic control characteristics and further information about the static characteristics. The theoretical predictions are verified by experimental measurements on a 40-W 1.5-MHz converter.     

DC-DC converter: four switches V/sub pk/=V/sub in//2, capacitive turn-off snubbing, ZV turn-on

A new four-switch full-bridge dc-dc converter topology is especially well-suited for power converters operating from high input voltage: it imposes only half of the input voltage across each of the four switches. The two legs of a full-bridge converter are connected in series with each other, across the dc input source, instead of the usual topology in which each leg is connected across the dc source. The topology reduces turn-off switching losses by providing capacitive snubbing of the turn-off voltage transient, and eliminates capacitor-discharge turn-on losses by providing zero-voltage turn-on. (Switching losses are especially important in converters operating at high input voltage because turn-on losses are proportional to the square of the input voltage, and turn-off losses are proportional to the input voltage). The topology is suitable for resonant and nonresonant converters. It adds one bypass capacitor and one commutating inductor to the minimum-topology full-bridge converter (that inductor is already present in many present-day converters, to provide zero-voltage turn-on, or is associated with one or two capacitors to provide resonant operation), and contains a dc-blocking capacitor in series with the output transformer, primary winding, and some nonresonant converters (that capacitor is already present in resonant power converters). The paper gives a theoretical analysis, and experimental data on a 1.5-kW example that was built and tested: 600-Vdc input, 60-Vdc output at up to 25A, and 50-kHz switching frequency. The measured performance agreed well with the theoretical predictions. The measured efficiency was 93.6% at full load, and was a maximum of 95.15% at 44.8% load.     

A novel soft-switching full-bridge DC/DC converter: analysis,design considerations, and experimental results at 1.5 kW, 100 kHz

The addition of an external commutating inductor and two clamp diodes to the phase-shifted PWM (pulsewidth modulated) full-bridge DC/DC converter substantially reduces the switching losses of the transistors and the rectifier diodes, under all loading conditions. The authors give analyses, practical design considerations, and experimental results for a 1.5 kW converter with 60 V, 25 A output, operating at 100 kHz clock frequency and 95% efficiency     

Origins and early years of the American Psychological Association, 1890–1906.

Many personal and professional concerns led G. Stanley Hall to found the American Psychological Association (APA) in 1892, and its subsequent development through its earliest years reflected the cultural and institutional milieu in which it emerged, much more than it did the intellectual and scientific issues that interested psychologists during that period. This essay traces APA's evolution through 1906 as an adaptation to the ecological setting in which it found itself and concludes that psychology's institutional relations with other sciences (and psychologist's professional relations with other scienctists) did much to shape the ecological niche in which APA established itself during its first decade and a half. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

2-Chlorodeoxyadenosine therapy in advanced chronic lymphocytic leukaemia

The therapeutic potential of 2-chlorodeoxyadenosine (CdA) in patients with advanced chronic lymphocytic leukaemia (CLL) remains controversial with response rates in clinical trials ranging from 44 to 67%. This report describes our experience with CdA in 22 CLL patients having already undergone previous treatment. CdA was given by continuous intravenous infusion at a dose of 4 mg/m2/day for 7 days (4 patients) or as 2-h intravenous infusions at a dose of 5.6 mg/m2/day for 5 days (18 patients). Partial (n = 5) or complete (n = 2) response was obtained in 7 cases. As compared to unresponsive patients, responding subjects received CdA earlier in the course of their disease (mean interval between diagnosis and CdA therapy 58 vs 102 months), were less thrombocytopenic at initiation of CdA (mean platelet count 165 x 10(9)/L vs 81 x 10(9)/L) and experienced less severe neutropenia during the first course of therapy (mean minimal neutrophil count 1.55 x 10(9)/L vs 0.43 x 10(9)/L). None of 6 patients with CLL refractory to fludarabine responded to CdA. An evaluation of haematological toxicity during the first course of treatment showed grade 4 neutropenia (< 0.5 x 10(9)/L) in 7 cases and grade 4 thrombocytopenia (< 25 x 10(9)/L) in one of 19 cases where the platelet count was greater than 25 x 10(9)/L at initiation of CdA. In comparison with earlier reports, the present series of patients had received relatively heavy prior therapy, experienced more severe haematological toxicity and demonstrated a lower total response rate.     

APA's first publication: Proceedings of the American Psychological Association, 1892–2893.

Presents a reprint of Secretary J. M. Cattell's (1894) Proceedings of the American Psychological Association. The 1st publication of the American Psychological Association (APA) contained the proceedings of the 1st and 2nd annual meetings held in 1892 and 1893, including an address by the president of the APA in 1893. Abstracts of papers presented at the meetings focus on topics that include observation errors, pain, the relation of stimulus intensity to the reaction time (RT), visual memory, and the problem of psychological measurement. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Epstein-Barr virus serology and Epstein-Barr virus-associated lymphoproliferative disorders in pediatric liver transplant recipients

Epstein-Barr virus serology was performed before and after transplantation in 116 patients of a total series of 261 pediatric OLT recipients. Thirty-nine percent had no immunity before OLT, but this percentage decreased to 11.2% at 6 months and 10.5% at 2 years after transplantation. In this series, 10 children developed a B cell lymphoproliferative disease. Four had adenotonsillar involvement, 2 of them with associated digestive tract invasion. Three of these are alive, 2 after retransplantation for chronic rejection subsequent to arrest of immunosuppression. The fourth died from bone marrow aplasia. Three patients with multiorgan involvement died from multisystemic failure. The remaining 3 patients had a pseudotumoral mass. Two of these are alive, 1 after retransplantation for hepatic localization and secondary vascular and biliary complication. The last died from cachexia. Four patients developed the syndrome after viral reactivation, and 6 after primo infection. Four patients were under FK506 rescue therapy. We conclude that a high rate of EBV primo infection is observed in the first months after transplantation. A significant percentage will develop EBV-associated lymphoproliferative disease, which causes death in half of the patients, including all these with multiorgan involvement. Half of the patients may survive, but because immunosuppression must be stopped, retransplantation for chronic rejection is often necessary in survivors.