玄机暗藏

正机关盒,将各种玄妙的机关设计藏于一方小小的盒子间。开盒的人,热衷于利用知识、灵感、逻辑推理等破解层层机关,来获得打开它时的趣味和成就感;而制盒的人,喜欢给开盒者出难题,极尽各种工艺和谜题去增添机关盒的"魔力"。还有的人,从狂热的开盒者变身制盒艺术家,甚至因为太热爱设计机关盒而改了名字!美国机关盒艺术家卡更·桑德(Kagen Sound),原名谢弗(Schaefer)。因为痴迷于机关盒,他与妻子一起将姓氏变更为     

HDL‐Mimicking Peptide–Lipid Nanoparticles with Improved Tumor Targeting

Targeted delivery of intracellularly active diagnostics and therapeutics in vivo is a major challenge in cancer nanomedicine. A nanocarrier should possess long circulation time yet be small and stable enough to freely navigate through interstitial space to deliver its cargo to targeted cells. Herein, it is shown that by adding targeting ligands to nanoparticles that mimic high‐density lipoprotein (HDL), tumor‐targeted sub‐30‐nm peptide–lipid nanocarriers are created with controllable size, cargo loading, and shielding properties. The size of the nanocarrier is tunable between 10 and 30 nm, which correlates with a payload of 15–100 molecules of fluorescent dye. Ligand‐directed nanocarriers targeting epidermal growth factor receptor (EGFR) are confirmed both in vitro and in vivo. The nanocarriers show favorable circulation time, tumor accumulation, and biodistribution with or without the targeting ligand. The EGFR targeting ligand is proved to be essential for the EGFR‐mediated tumor cell uptake of the nanocarriers, a prerequisite of intracellular delivery. The results demonstrate that targeted HDL‐mimetic nanocarriers are useful delivery vehicles that could open new avenues for the development of clinically viable targeted nanomedicine.