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Silica gel or zeolites AlPO-5 and SAPO-34 are recommended as adsorbents in water-driven heat pumps because of their selective water uptake. Secondary energy, like solar energy, can be used for regeneration of loaded adsorbers. In case of the availability of only low energy levels, the use of dealuminated Y zeolite (DAY) is the better choice because of the infinitely variation of its hydrophilic properties by tailoring of the framework Si/Al ratio. Actual data on the hydrothermal stability of DAY are lacking. Thus, we report on the long-term behavior of DAY zeolites with different Si/Al ratios.  相似文献   
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This review classifies drug-design strategies successfully implemented in the development of histone deacetylase (HDAC) inhibitors, which have many applications including cancer treatment. Our focus is on especially demanded selective HDAC inhibitors and their structure-activity relationships in relation to corresponding protein structures. The main part of the paper is divided into six subsections each narrating how optimization of one of six structural features can influence inhibitor selectivity. It starts with the impact of the zinc binding group on selectivity, continues with the optimization of the linker placed in the substrate binding tunnel as well as the adjustment of the cap group interacting with the surface of the protein, and ends with the addition of groups targeting class-specific sub-pockets: the side-pocket-, lower-pocket- and foot-pocket-targeting groups. The review is rounded off with a conclusion and an outlook on the future of HDAC inhibitor design.  相似文献   
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Due to the growing energy requirements, the proportion of external thermal insulation composite systems (ETICS) installed has increased significantly during the past 50 years. Due to the longevity of these systems, ETICS waste is currently accumulating. Owing to the complex construction as well as a multitude of differently installed materials and substances of the past generations, there are many uncertainties and problems with the clean and low-pollutant processing of such systems. In the frame of this work, the ETICS were processed and sorted before being screened for ingredients or pollutants as well as for the purity of the recovered material fractions.  相似文献   
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Network function virtualization (NFV) allows to model network services as graphs interconnecting virtual network functions (VNFs), which may include nested VNFs, modeled as subgraphs of VNFs or end points. To query the performance data of network services modeled as abstract and high‐level graphs is challenging because of the recursivity of the NFV architecture and the elasticity and dynamicity provided by the NFV infrastructure. We propose to use Datalog, a declarative logic programming language, to build a framework that supports efficient data aggregation for performance metrics of recursively modeled network services. We present our recursive query language for automatic and flexible decomposition and aggregation of NFV performance metrics and describe example use cases for both compute and network metrics. We also describe the design and implementation of a proof‐of‐concept query engine using the language. Our performance evaluation shows that the total query latency is dominated by retrieval times of performance metrics from infrastructure databases, and the time for execution and automatic decomposition of high‐level queries by the query engine itself increases linearly with the size of the service graph up to 1000 nodes. Hence, our evaluations show that the query engine scales well, bounded mainly by the limited execution capabilities of our test environment. Furthermore, it can handle multiple concurrent queries up to the concurrency limits of the backend database in use. The proposed query language and engine are thus effective in recursively retrieving performance metrics of NFV environments supporting large‐scale service graphs and large numbers of query requests.  相似文献   
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Small hydro power systems (SHPSs) are increasingly installed in water distribution systems (WDSs). With only minor adaptations in a WDS, pressure surplus can be utilised. In such systems, a water surplus is also often available. In this work, water consumption data of a real Alpine WDS over one year are used as an input for an Epanet2 long-term simulation model to assess such a SHPS. In addition, the combinations of pressure and water surplus devices in a WDS are investigated. For such a specific investigated case, the yearly profit of 1750 € for a single SHPS could be increased to 3550 € when combining two interacting devices. Further, necessary and upcoming rehabilitation measures are investigated concerning their positive impact on the energy production potential and how additional costs (e.g., higher diameters (200 mm instead of 125 mm)) can be compensated by additional profits from energy production (maximum 5250 € per year).  相似文献   
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This DFG-funded research project aimed to gain a better understanding of the mechanisms of the W-Cl repair principle within the framework of fundamental investigations, to contribute to the creation of the necessary basis for a broader application of the repair principle in practice. The focus was on the development of a model to describe the chloride redistribution after the application of a system sealing surface protective coating. On the basis of Fick's second law of diffusion, a mathematical model with a self-contained analytical solution was developed, with the help of which the chloride redistribution after application of a system sealing surface protective coating can be calculated under the idealized assumption of complete water saturation of the concrete. Furthermore, the influence of the dehydration of the concrete, expected as a result of the application of the repair principle W-Cl, on the chloride redistribution was investigated. On the basis of laboratory tests and numerical simulations, material-specific reduction functions were developed to quantify the relationship between the chloride diffusion coefficient and the ambient humidity.  相似文献   
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Lactose solutions of up to 50% (w/v) were incubated with lactases and glucose isomerases for subsequent implementation in dairy product samples to enhance sweetness. A degree of hydrolysis of >90% and of isomerisation of 50% were attainable. The sensory sweetening power of lactose in solutions of up to 50% (w/v) can be enhanced 2–3 times. Based on sensory experiments, application of this bi‐enzymatic system in yoghurt and pudding samples allowed for a 10–20% (w/w) reduction in the total sugar content, whilst retaining equal sweetness. The growth of yoghurt starter cultures was not affected, yet furosine formation more than doubled in high heated, enzyme‐modified milk.  相似文献   
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