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排序方式: 共有808条查询结果,搜索用时 78 毫秒
1.
Bogdan Obric Bogdan Sorohan Liliana Tu Gener Ismail 《International journal of molecular sciences》2021,22(7)
Systemic lupus erythematosus (SLE) is the prototype of autoimmune disorders caused by a loss of tolerance to endogenous nuclear antigens triggering an aberrant autoimmune response targeting various tissues. Lupus nephritis (LN), a major cause of morbidity and mortality in patients with SLE, affects up to 60% of patients. The recent insights into the genetic and molecular basis of SLE and LN paved the way for newer therapies to be developed for these patients. Apart from the traditional B-cell-centered view of this disease pathogenesis, acknowledging that multiple extrarenal and intrarenal pathways contribute to kidney-specific autoimmunity and injury may help refine the individual therapeutic and prognostic characterization of such patients. Accordingly, the formerly induction-maintenance treatment strategy was recently challenged with the exciting results obtained from the trials that evaluated add-on therapy with voclosporin, belimumab, or Obinutuzumab. The scope of this review is to provide an insight into the current knowledge of LN pathogenesis and future therapeutic strategies. 相似文献
2.
Dr. Lilia Clima Bogdan Florin Craciun Dr. Andrea Angeli Andrea Petreni Alessandro Bonardi Dr. Alessio Nocentini Dr. Fabrizio Carta Prof. Paola Gratteri Prof. Mariana Pinteala Prof. Claudiu T. Supuran 《ChemMedChem》2020,15(21):2052-2057
We report novel molecules incorporating the nontoxic squalene scaffold and different carbonic anhydrase inhibitors (CAIs). Potent inhibitory action, in the low-nanomolar range, was detected against isoforms hCA II for sulfonamide derivatives, which proved to be selective against this isoform over the tumor-associate hCA IX and XII isoforms. On the other hand, coumarin derivatives showed weak potency but high selectivity against the tumor-associated isoform CA IX. These compounds are interesting candidates for preclinical evaluation in glaucoma or various tumors in which the two enzymes are involved. In addition, an in silico study of inhibitor-bound hCA II revealed extensive interactions with the hydrophobic pocket of the active site and provided molecular insights into the binding properties of these new inhibitors. 相似文献
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Mihail Elisa Lucica Boroica Bogdan Alexandru Sava Stefan Marian Iordache Ana-Maria Iordache Ileana Cristina Vasiliu Raluca Constantina Stefan Aurelian Catalin Galca Victor Kuncser Mihai Eftimie 《Journal of the American Ceramic Society》2020,103(7):3978-3990
This work is focused on investigation of thermal, structural, optical, magnetic, and magneto-optical properties of novel titanium phosphate-tellurite glass applied as Faraday rotators. The glass belonging to the system 35Li2O–10Al2O3–5TiO2–45P2O5–5TeO2 was prepared by a nonconventional wet route of raw materials processing, followed by melting-quenching-annealing steps. Some important physical properties of the investigated glass have been measured and calculated, providing knowledge related to glass compactness, electronic structure, glass forming capability, etc. XRD analysis evidenced an amorphous network structure of the investigated glass. The optical absorption in the Vis domain is mainly due to Ti3+ ions and Te2 clusters formed during the glass melting process. A relatively low optical absorption is noticed over 600 nm that activates a significant Faraday magneto-optical effect. Photoluminescence bands in the blue, red, and infrared domains are observed, caused by Te2 clusters formed during the glass melting process. The magnetization in dependency on applied magnetic field reveals a complex behavior of the glass, depending on temperature. Thus, it is found a ferromagnetic behavior up to 2000 Oe, a paramagnetic component up to 40 000 Oe, followed by a diamagnetic one over 40 000 Oe. Faraday rotation angle and Verdet constant values in the visible domain are correlated with the reduced TeO2 content of the glass. 相似文献
6.
Anh Thi Hong Bui Daniel Cozzolino Bogdan Zisu Jayani Chandrapala 《International Journal of Food Science & Technology》2021,56(8):3948-3959
The effects of low-frequency ultrasound on the production of volatile compounds in model casein protein systems containing various fat concentrations of 2%, 4% and 6% (w/w) were investigated. Ultrasound application was performed at 20 kHz for up to 10 min which corresponded to energy densities ranging from 9.54 to 190.8 J mL−1. Similar volatile compounds were detected both in pure fat and mixtures of casein and fat (CF) systems. These volatiles belonged to the groups of aldehydes, ketones, esters, alcohols and hydrocarbons, which were the products of oxidation of lipids or protein degradation due to acoustic cavitation. The amount of fat in the casein systems had minor effects on the production of volatiles, whereas the production of volatile compounds was significantly affected by the ultrasound treatment. Short sonication times <5 min generated similar volatile profiles to the untreated samples. In contrast, prolonged sonication for 5 and 10 min considerably increased the production of volatile compounds and the amounts of fatty acids. Thus, the application of low–frequency ultrasound for short periods should be considered to minimise the production of volatile compounds which can ultimately affect the taste. 相似文献
7.
Emergencies, and efforts to address them, create disruptions to local and global supply chains and surges in demand of emergency resources, which substantially affect global production. Reconfigurable manufacturing systems are promising solutions to improve flexibility and to reduce the effort needed to adapt supply chains and production networks to fit a perturbed environment. This paper proposes a method for coordination of reconfigurable manufacturing resources from multiple enterprises to structure ad-hoc production networks for critical products required in emergencies. Network optimization models and interaction algorithms are integrated to evolve the production network through synchronous machine-level and network-level reconfiguration driven by data. 相似文献
8.
Amalia Mesaros Cristina D. Ghitulica Mihaela Popa Raluca Mereu Adriana Popa Traian Petrisor Jr. Mihai Gabor Adrian Ionut Cadis Bogdan S. Vasile 《Ceramics International》2014
Zn1−xCoxO (x==0.05, 0.10, 0.15) nanoparticles have been synthesized by an alternative wet-chemical synthesis route using the SimAdd technique. The as-obtained powders were investigated by FT-IR spectroscopy, X-ray diffraction and thermal analysis correlated with evolved gas analysis (TG–DTA–FT-IR) in order to determine their chemical nature, crystalline structure and to establish the decomposition sequences. The precipitates are generally amorphous, but low-intensity reflection peaks assigned both to the zinc oxalate dihydrate, and zinc hydroxide can be observed in the recorded patterns, indicating that hydroxy-oxalate precipitates were obtained. The structure, morphology and magnetic properties of the thermally treated samples have been investigated by X-ray diffraction, FT-IR, HRTEM, SAED, UV–vis and EPR. XRD studies reveal a hexagonal wurtzite-type structure for all Zn1−xCoxO samples. TEM investigations show particle size between 28 and 37 nm, with spherical and polyhedral shapes and with tendency to form aggregates. The presence of a Co3O4 secondary phase was evidenced by XRD, UV–vis and EPR for the Zn0.85Co0.15O sample. The ferromagnetic behavior of the samples was revealed. The paper highlights that by varying the cobalt concentration it is possible to modulate the structural, morphological, optical and magnetic properties. 相似文献
9.
Inclusion of flaxseed in turkey diets decreases the n‐6/n‐3 PUFA ratio and increases the proportion of biologically active EPA and DHA without affecting meat quality 下载免费PDF全文
10.
This article presents investigations related to the turning of stainless steel as a representative of difficult-to-cut materials and the effectiveness of selected chip breakers working in the local machining environment. Martensitic steel AISI 416 was used to test two commercially available types of chip breaker. The efficiency of a chip breaker working in the range of cutting conditions recommended (by the tool manufacturers) was the aim of the turning tests. As a result of the investigations an algorithm of cutting condition selection, combining both the cutting tests and the simulation procedure for the efficiency of the chip breaker was created. The vision system, equipped with a high-speed camera was used for chip form estimation. Simultaneously, the cutting force components were measured to check if the simulation calculation was correct. The FEM simulation was applied to estimate the manner in which the chip groove was filled. The article presents certain recommendations for cutting condition correction in the local machining environment for the purpose of achieving an acceptable chip form. 相似文献