Light-induced electron spin polarization in the ground state of water-soluble copper porphyrins

Light-induced spin-polarized transient EPR spectra are reported for several water-soluble copper porphyrins. The spectra are assigned to the doublet ground state, with emissive spin polarization resulting from photoexcitation and subsequent electronic relaxation. In contrast to other systems for which polarization of a doublet ground state has been observed, the exchange interactions in the copper porphyrins are strong and the geometry is fixed. It is proposed that intersystem crossing from the photoexcited trip-doublet to the trip-quartet state can lead to net polarization of the spin system and that this polarization is maintained during electronic decay, possibly via charge-transfer and exciplex states. The intensity of the observed spin polarization is essentially independent of the molecular orientation in the external field, but is strongly dependent on the nature of the charged peripheral groups. Possible reasons for this behavior are discussed.     

Simulation model of general human and humanoid motion

In the last decade we have witnessed a rapid growth of Humanoid Robotics, which has already constituted an autonomous research field. Humanoid robots (or simply humanoids) are expected in all situations of humans’ everyday life, “living” and cooperating with us. They will work in services, in homes, and hospitals, and they are even expected to get involved in sports. Hence, they will have to be capable of doing diverse kinds of tasks. This forces the researchers to develop an appropriate mathematical model to support simulation, design, and control of these systems. Another important fact is that today’s, and especially tomorrow’s, humanoid robots will be more and more humanlike in their shape and behavior. A dynamic model developed for an advanced humanoid robot may become a very useful tool for the dynamic analysis of human motion in different tasks (walking, running and jumping, manipulation, various sports, etc.). So, we derive a general model and talk about a human-and-humanoid simulation system. The basic idea is to start from a human/humanoid considered as a free spatial system (“flier”). Particular problems (walking, jumping, etc.) are then considered as different contact tasks – interaction between the flier and various objects (being either single bodies or separate dynamic systems).     

Dynamic range of coherent analog fiber-optic links

We investigate the performance of coherent analog optical links employing amplitude modulation (AM), phase modulation (PM), and frequency modulation (FM). The performance of these coherent links is compared to that of AM direct-detection (DD) links. The signal-to-noise ratios, nonlinearities, and-spurious-free dynamic ranges (SFDR's) of the foregoing links are evaluated. We calculate the SFDR for links using DFB and Nd:YAG lasers with typical linewidths of 10 MHz and 5 kHz, respectively. The performance of PM and FM links is dominated by phase noise above a critical value of received optical power. For a linewidth of 10 MHz, and SFDR's of PM and FM links are 30 and 31 dB, respectively, for a received optical power above -27 dBm in a 1 GHz bandwidth. For a linewidth of 5 kHz, the corresponding SFDR's above a received power level of 0 dBm are 51 and 53 dB. The performance of DD and AM links is dominated by RIN above a critical value of received optical power. For a RIN level of -155 dB/Hz, the SFDR's of DD and AM links are 49 and 47 dB, respectively, for a received optical power of 10 dBm in a 1 GHz bandwidth. The SFDR's of the DD and coherent links used for transmission of subcarrier-multiplexed (SCM) signals are also derived. We evaluate target laser parameters needed by a number of different applications. For AM video and antenna remoting applications, linewidths of <1 and <3 kHz are required to use PM and FM links, respectively. For FM video, linewidths of <150 and <350 MHz are required to use PM and FM links. For SCM digital applications, linewidths of <80 and <200 MHz are required to use PM and FM links. The paper concludes with a discussion of system implementation issues, including linearization, optical frequency modulation, balanced receivers, and IF issues     

Evaluation of RU28318 and RU40555 as selective mineralocorticoid receptor and glucocorticoid receptor antagonists, respectively: receptor measures and functional studies

BACKGROUND: Australia has a high rate of cardiovascular disease mortality and also a significant proportion of migrants. Little is known about the morbidity experience or cardiovascular risk factors among the larger migrant groups, and this is especially true of the Arabic-speaking population. OBJECTIVES: The objectives of the study were to identify the health profile of Arabic-speaking people in Sydney, Australia, to explore the relationship between level of acculturation and health indicators and to identify the morbidity profile of patients presenting to Arabic-speaking general practitioners (GPs). DESIGN: Adult Arabic-speaking patients aged 18-70 years attending 20 Arabic-speaking GPs in Canterbury, Sydney, during the 2-week study period were asked to complete a self-administered questionnaire in Arabic or English while waiting to see the GP. Data on cardiovascular risk factors, level of acculturation and reasons for seeing the GP were collected. RESULTS: Data were collected from 851 patients (62% response rate). Almost three-quarters (73%) of males and 36% of females were considered overweight or obese (body mass index > 25). Of concern, 37% of males and 28% of females were smokers. Females were significantly less likely to have been tested for diabetes (p < .05) or raised blood pressure (p < 0.05) compared with females in NSW. Respondents consumed less bread per day and more fruits than in NSW overall. Respiratory complaints (flu and colds) were the most frequently reported reasons for patient encounters. Except for the youngest age group, males gave more reasons for encounters than females. CONCLUSIONS: Consecutive sampling of ethnic patients attending a GP who speaks their language holds promise as a method of needs assessment with migrant populations. Further, our results suggest that smoking and weight reduction programs are priorities in the Arabic-speaking community. These risk factors are ideal for intervention by GPs speaking the same language.     

Explosion risks during the confined storage of bituminous coals : Calculation of gaseous hydrogen accumulation in ship holds

Bituminous coal piles stored in the open air can undergo autocatalytic heating accompanied by the emission of small but appreciable amounts of molecular hydrogen. When the coal is contained in a confined space and the temperature reaches 40°C, accumulation of hydrogen is expected. This process has been observed for a wide variety of bituminous coals. The amount of hydrogen gas expected to accumulate in the air pocket above the coal cargo in ship holds (assuming that the coal's temperature approaches 40°C during the voyage) has been calculated. The results clearly indicate that in most cases the hydrogen concentration will be appreciably above the lower explosion limit in air. Hence when bituminous coals are stored in a confined space (e.g. a ship hold), the explosive risk of hydrogen should be taken into account.     

The Prominin-1-Derived Peptide Improves Cardiac Function Following Ischemia

Myocardial infarction (MI) remains the leading cause of death in the western world. Despite advancements in interventional revascularization technologies, many patients are not candidates for them due to comorbidities or lack of local resources. Non-invasive approaches to accelerate revascularization within ischemic tissues through angiogenesis by providing Vascular Endothelial Growth Factor (VEGF) in protein or gene form has been effective in animal models but not in humans likely due to its short half-life and systemic toxicity. Here, we tested the hypothesis that PR1P, a small VEGF binding peptide that we developed, which stabilizes and upregulates endogenous VEGF, could be used to improve outcome from MI in rodents. To test this hypothesis, we induced MI in mice and rats via left coronary artery ligation and then treated animals with every other day intraperitoneal PR1P or scrambled peptide for 14 days. Hemodynamic monitoring and echocardiography in mice and echocardiography in rats at 14 days showed PR1P significantly improved multiple functional markers of heart function, including stroke volume and cardiac output. Furthermore, molecular biology and histological analyses of tissue samples showed that systemic PR1P targeted, stabilized and upregulated endogenous VEGF within ischemic myocardium. We conclude that PR1P is a potential non-invasive candidate therapeutic for MI.     

Pickup (critical) velocity of particles

This work presents experimental results on pickup velocity (critical velocity) measurements for a variety of particulate solids. The present experiments together with previously published experiments of a number of researchers encompass about 100 measurements of 24 materials for a wide range of particle sizes, shapes and densities. Based on the experimental results, three zones are defined by establishing simple relationships between the Reynolds and Archimedes numbers. The empirical relationships were further modified by taking into account the pipe diameter and particle shape (sphericity). The three-zone model was shown to reasonably correlate to Geldart's classification groups.