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Research was undertaken to understand how to provide the most appropriate support for novice designers in engineering design. However, how designers apply their experience and knowledge is not understood and further research in this area is required. This paper describes an observational study to understand how novice and experienced designers approach design tasks. Electronic Publication  相似文献   
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High cycle fatigue of bolted connections Extensive tests regarding the influences on the fatigue of bolt‐nut‐connections of preloading with torsion, of preloading with yielding, of loading with superimposed bending and of the tested lot are processed. These influences are not yet known according to VDI 2230. New testing devices were designed for these tests, which allow a far less expensive operation and may easily be used for bolts of diameters up to M100 and testing frequencies up to 1000 Hz. The validity of fatigue resistance according to VDI 2230 is specified with respect to the test results. The determined influence of the tested lots is unexpectedly high. The manufacturing process of bolts should be improved to minimize this influence.  相似文献   
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Twenty-seven patients with nonsquamous cell carcinoma of the cervix were entered into a Phase II study of amonatide; 24 patients were evaluable for toxicity, while 23 were evaluable for response. Patients received amonafide, 300 mg/m2, intravenously for 5 consecutive days every 3 weeks. The median age of patients was 45 years. All but two patients were completely ambulatory. Twelve patients had received prior chemotherapy, while 22 had been treated with radiation therapy. One of 27 (4.3%) patients had a partial response (PR) to this regimen and 13 (56.5%) had stable disease. Sixteen patients experienced a median white blood cell (WBC) nadir of 350/mm3, seven developed life-threatening thrombocytopenia, and one had severe anemia requiring transfusion. Nonhematologic toxicity was mild. Amonafide had insignificant activity in these patients with nonsquamous cell carcinoma of the cervix.  相似文献   
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A great number of complex electronic devices are now part of our everyday lives. While many of us learn to handle these products by trial and error; others, especially older users with little experience in using electronic devices, need support. In order to allow the user maximum flexibility in terms of learning time and location, a training programme is presented which is implemented as part of the software embedded in the product itself. Particular focus is placed on the effect of adaptive training on learning. In this study, the training versions differed in their ability to adjust their complexity to the user's experience (adaptive user interface complexity) and their capability to support the learner by prompting them during the learning process (adaptive training advice). The results show that the adjustment of complexity had a positive effect on users’ experience: elderly users who trained with an adaptive interface were more successful in learning to use a mobile phone. Adaptive training advice, however, was found to have no significant effects on learners’ success and reduced their self-efficacy. This work offers guidelines on how to design integrated training applications for electronic devices that successfully help elderly users with little prior experience.  相似文献   
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In spite of great advancements in multimedia data storage and communication technologies, compression of medical data remains challenging. This paper presents a novel compression method for the compression of medical images. The proposed method uses Ripplet transform to represent singularities along arbitrarily shaped curves and Set Partitioning in Hierarchical Trees encoder to encode the significant coefficients. The main objective of the proposed method is to provide high quality compressed images by representing images at different scales and directions and to achieve high compression ratio. Experimental results obtained on a set of medical images demonstrate that besides providing multiresolution and high directionality, the proposed method attains high Peak Signal to Noise Ratio and significant compression ratio as compared with conventional and state-of-art compression methods.  相似文献   
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The optimization of the manufacturing/assembly tolerances and processes in ITER Experimental Nuclear Fusion Device is one of the key tasks to optimize the fabrication cost, to prevent problems during assembly and to ensure that the critical homogeneity of the magnetic field and the positioning requirements of the plasma facing components can be achieved. This task is further complicated by the strong interplay among the various Tokamak systems, as for instance in the inner region of the machine where the clearances between Central Solenoid, Toroidal Field Coils, Thermal Shield, Vacuum Vessel and In-Vessel components have been minimized for their large influence on the magnetic flux and the overall machine cost.A 3D tolerance simulation analysis of ITER Tokamak machine has been developed based on 3DCS dedicated software. The dimensional variation model is representative of Tokamak functional tolerances and processes, predicting accurate values for the amount of variation on critical areas. In addition, dimensional simulations help to determine the key tolerances that contribute to a particular variation.This paper describes the current status of the Tokamak dimensional variation studies and its management plan, highlighting the status of compliance of allocated tolerances with input requirements. Management of risk issues and corrective actions are also described.  相似文献   
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At 400 °C in 20 min runs, coal was converted by methanol/KOH systems to a product which was extractable by pyridine fully, and 15–25% by methanol. The methanol-sotuble fraction is significantly enriched in hydrogen relative to the starting coal, reduced in both N and organic S, and was fluid at room temperature. It was established that this liquid product was derived from the coal, and not the methanol. The liquid was distillable at 300 °C/133 Pa (1 torr), and an analysis of the liquid by gas chromatography/mass spectrometry techniques shows it to consist of significant quantities of butyrolactone, polymethyl phenols, and some unidentified compounds having major C4H7O and C4H7O2 MS fragments. The methanol-insoluble products were hydrogen-enriched also, but to a lesser degree. The suggested conversion scheme is similar to that proposed for isopropyl alcohol, where alkoxide ion donates hydride to the coal, followed by proton abstraction by the anionic intermediate from the alcohol medium. In model-compound studies at 400 °C with the system, it was found that phenyl ether was converted in 33% yield to a collection of polymethyl phenols, similar to those found in the coal distillate. Anthracene was converted in about 80% yield to 9,10-dihydroanthracene. Biphenyl, phenanthrene and bibenzyl were found to be unreactive in our system.  相似文献   
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