Characterisation of oleoresins extracted from tomato waste by liquid and supercritical carbon dioxide

Tomato waste is characterised by high amounts of bioactive compounds, such as carotenoids, polyphenols and essential fatty acids. In this work, oleoresins were produced from tomato waste (skins + seeds) and skins using carbon dioxide under liquid and supercritical conditions. The use of ethanol as a co-solvent was also evaluated. Compositions of the oleoresins were analysed and compared to oleoresin obtained by means of an organic solvent, which was used as the control. Oleoresin extraction from the waste by liquid and supercritical CO₂ provided the highest yields (12.5%–12.9%). The extracts obtained from the skins with supercritical CO₂ without ethanol had the highest content of α- and γ-tocopherols (80 and 575 mg/100 g oleoresin, respectively), while lycopene and β-carotene were found at 205 and 75 mg/100 g oleoresin, respectively. The highest quantity of polyphenols (9305 mg GAE/100 g oleoresin) was found in the oleoresin extracted from skin by supercritical CO₂ with ethanol. All oleoresins were characterised by a high antioxidant activity, which improved with the synergy of carotenoids, tocopherols and polyphenols.     

Coupled instability of thin-walled members under combined bending moment, axial and shear force

In this paper we analyse the behaviour of thin-walled steel members with an I-shaped cross-section, in the presence of phenomena of coupled instability as overall-local type and combined state of stress of bending moment, axial and shear force. The analysis has been made by the ‘column model method’ and it has been used for bending moment-curvature-axial force diagrams, modified by the presence of local instability for web buckling of steel beams.

The previous analysis allows one to define interaction diagrams M_Imax−λ−N, which can be used to check the steel members in relation to the overall slenderness and the local slenderness of the web panel.     

Autochthonous white grape pomaces as bioactive source for functional jams

Seeds and skins from grape pomaces of Pecorello and Mantonico cv underwent extraction (ultrasound–assisted or maceration), in order to obtain added-value ingredients for the production of a functional pear jam. The antioxidant features of the extracts were tested by in vitro colorimetric assays. Among seeds, Mantonico by maceration (MSC) showed the best results, as well as Mantonico by ultrasound-assisted extraction (MBs) among skin extracts. The selected extracts were fully characterised by NMR and MS techniques, confirming the presence of many polyphenols, flavonoids and tannins among others. Pectin was then derivatised by the grafting procedure with the active molecules of MBs and MSC. The latter produced the best antioxidant polymer also without toxicity evaluated using Caco-2 cells and was used for the jam preparation. The functional pear jam showed improved antioxidant performances in comparison with its non-functional counterparts as well as its maintenance over time (15 days).     

FRP confinement of masonry: analytical modeling

International and National Building Codes provide requirements for design and construction of new masonry structures, but design provisions for the repair, retrofitting, and rehabilitation of masonry structures are not always available and included in the same documents. Due to the extremely large variability in masonry performances, equations of general validity cannot often be provided, namely relationships suitable for every masonry type. Despite the great research effort in the experimental field, considerable theoretical work is still needed to fully outline a definitive analytical model to predict the behavior of FRP confined masonry. Most of the available models, empirical in nature, have been calibrated against their own sets of experimental data, or they are simply derived from concrete. Even if large amount of results obtained for concrete led to consolidated design guidelines, they cannot be simply extended to masonry. In this study, a mechanically based confinement model is proposed based on mechanical parameters able to differentiate similar masonry types and to highlight that they present different confinement performance. Crucial aspects of masonry confinement will be also discussed, namely: lateral dilation; confinement effectiveness; lateral pressure also in non-circular shapes; effective strain of FRP.     

An integrated approach to the facilities and material handling system design

The facility layout problem involves the optimal location of manufacturing facilities into a workshop. The classical approach to the layout design is carried out in two separate steps: the first step is the construction of the block layout, i.e. the location of the departments into the workshop, and the second step is the design of the material handling system. The separate optimization of these two aspects of the problem leads to solutions that can be far from the total optimum. In this paper, an integrated approach to the facilities and material handling system design is proposed. Referring to a physical model, named the bay structure , and to a unidirectional AGV system, a genetic approach is proposed to individuate the locations of the departments, the positions of the pickup/delivery stations and the direction of the flow-path. The minimization of material handling cost is adopted as optimality criterion.     

Present status of the conceptual design of the EU test blanket systems

The EU Breeding Blanket Programme aims the testing of two blankets concept in ITER in form of Test Blanket Modules. In the equatorial port #16 the two EU TBMs – a solid and a liquid blanket concept – will be exposed to the plasma and the complex system of their auxiliary systems dedicated to heat and Tritium removal will be integrated in the surrounding ITER buildings. The development of the conceptual design of the EU TBM System is the main objective of the Grant F4E-2008-GRT-09 contract launched by F4E and assigned to a European Consortium. This paper presents an overview of the results after about 20 months of activities: namely, the design of the main sub-systems of the EU TBSs and a concept of integration in ITER.     

A new cooling scheme for the HCLL TBM

The Helium Cooled Lithium Lead (HCLL) blanket is one of the two blanket concepts selected by the European Union to be tested in ITER. It is based on the use of Eurofer as structural material, helium as coolant and eutectic lithium–lead as breeder/neutron multiplier material. The design of the corresponding Test Blanket Module (TBM) for ITER has undergone several revisions in the last years. This paper presents an alternative cooling scheme for the HCLL-TBM, where the First Wall (FW) is cooled by vertical (poloidal) instead of horizontal (toroidal) channels. New Finite Element models have been developed and thermal and thermo-hydraulical analyses of the new design have been performed. Results show that the new cooling scheme presents several advantages with respect to the previous one: (i) the total number of cooling channels in the FW can be reduced; (ii) the overall pressure drops in one cooling channel are lower; (iii) the temperature profile in the breeding zone is more uniform.     

Standardization of islet isolation outcome – A new automatic system to determine pancreatic islet viability

Pancreatic islet transplantation is emerging as a therapeutic approach for patients affected by diabetes. This approach consists of a minimally invasive procedure replacing insulin-producing cells (pancreatic islets). The technique has been proven successful, but limitations have been identified. One of the major challenges of the procedure is the counting of the isolated pancreatic islets, which is currently jeopardized by subjectivity and inaccuracy. Determination of the accurate islet number is a crucial factor in determining the correlation between the isolation product and clinical outcome. In the proposed study, we have developed software capable of objectively evaluating islet numbers and other viability variables by image analysis. This software is based on image processing and feature extraction algorithms for recognition of the area of interest. This is the first step toward standardization of the isolation outcome and potential clinical success predictability.     

Multi-Criteria Decision Making support system for pancreatic islet transplantation

Pancreatic islet transplantation consists of replacing insulin-producing cells to restore normal glycemia in diabetic patients. This is a minimal invasive procedure that has been proved successful. Unfortunately unpredictability of islet transplant outcome remains a frustrating and costly issue limiting the clinical implementation of this procedure. Multiple variables are involved in the procedure and assessment is subjective to individual operators. The aim of this study was to generate a system expressing the probability of transplant success in relation to four classes of identified variables (donor, organ, isolation and recipient). We have proposed the utilization of Multi-Criteria Decision Making methods (MCDM) as a powerful tool for evaluating pancreatic islet transplant-related information with the goal to achieve optimal decision. Technique Ordered Preference by Similarity to the Ideal Solution (TOPSIS), one of the most widely used MCDM methods in decision support systems, was here utilized with modification to fit better in a medical system. In our modified method, we have utilized fuzzy logic in order to consider uncertain and vague data.     

Dental microwear of Griphopithecus alpani

The examination of microscopic dental wear allows inferences to be made about diet in extinct species. This study reconstructs the diet of Griphopithecus alpani, a 15 Ma fossil hominoid from the Miocene site of Pa?alar in north-western Turkey, using scanning electron microscopy (SEM) to examine the microscopic wear on its molar teeth. The microwear patterns of Griphopithecus are compared with those of three extant hominoid taxa-Gorilla gorilla gorilla, Pan troglodytes verus, and Pongo pygmaeus pygmaeus. The microwear on three occlusal wear surfaces is examined in this study, and sex and age differences are also included. Analysis of variance is performed on the following microwear variables-feature density, pit density, striation density, the ratio of pits relative to striations, pit widths, and striation widths. Griphopithecus has significantly higher microwear feature densities and higher percentages of pits than Gorilla. It also has larger pit frequencies and narrower striations than both Pan and Gorilla. There are no significant differences between the microwear patterns of Griphopithecus and Pongo. This suggests that the diet of Gripho-pithecus was more similar to that of Pongo, which consumes mainly fruit, and occasionally hard and unripe fruits and nuts, than to that of Pan and Gorilla. In addition, the high percentage of pits displayed by Griphopithecus may indicate that it was ingesting harder fruits and/or objects than the extant hominoids, although this is not a significant difference. There also are consistent variations in the microwear present on the three different wear facets examined in the study-Phase II facets display more microwear and pitting than the Phase I surface examined. The results of this study do not indicate variation in dental microwear according to sex or age.