Phospholipid Cyclosporine Prodrugs Targeted at Inflammatory Bowel Disease (IBD) Treatment: Design,Synthesis, and in Vitro Validation

Novel phospholipid (PL)-cyclosporine conjugates were prepared and studied as potential prodrugs for inflammatory bowel disease (IBD). Our approach relies on phospholipase A₂ (PLA₂), which is overexpressed in the inflamed intestinal tissues, as the prodrug activator to potentially release cyclosporine at the site of inflammation. PL-cyclosporine prodrug conjugates with methylene linkers of various lengths between the sn-2 position of the PL and cyclosporine were synthesized and evaluated for in vitro activation. Surprisingly, despite previous work indicating that conjugates with six methylene linkers between the lipid and drug would suffer rapid enzymatic hydrolysis, with cyclosporine this was not observed. However, compounds with longer linkers (n=10, 12 methylene units) display complete release of the drug by PLA₂-catalyzed hydrolysis, thus demonstrating the importance and profound impact of structural fine-tuning. This study represents a proof-of-concept for our hypothesis and a first step towards a truly targeted IBD treatment with cyclosporine that could be administered throughout the GI tract.     

Characterization of the field-effect conductivity distribution in pentacene thin-film transistors by a near-field scanning microwave microscope

Direct probing of the conductivity distribution in organic materials is motivated by the need to obtain a deeper understanding of carrier behavior in organic thin-film transistors (OTFT), organic electro-luminescent devices, organic photoconductors, and organic biosensors. Here we used a near-field scanning microwave microscope to visualize conductivity profiles in OTFT channel. Applying this technique to pentacene field-effect transistors has revealed changes of the conductivity distribution in the channel arising from the development and exhaustion of an accumulated charge region. The electric field profiles, the complementary image of conductivity profiles, which are visualized by using an optical second harmonic generation method, support the results. We anticipate that direct observation by this microwave method will find wide application in measurement of carrier conductivity in organic and nonorganic materials.     

Bunched electron beam properties measurement by means of single-shot multibeam cross-correlation technique

A new single-shot multibeam cross-correlation technique is proposed for the measurement of a bunched electron beam temporal structure. As an optical laser pulse modulated by the Coulomb field of the electron bunch in an electro-optical crystal, it is proposed to use a non-uniform pulse modulated both in time and in space. In the proposed technique, measurement of the time profile is realized during a single laser shot. In this case, as a result of electro-optical modulation of a non-uniform femtosecond pulse, the information on the time profile of the Coulomb field is contained in only the spatially shifted spectral components of the modulated pulse.     

A Multi-Level Approach to Measuring the Benefits of an Erp System in Manufacturing Firms

This research study examines associations between the business characteristics of manufacturing firms and their perceived benefits from ERP system investments. the perceived ERP benefits are measured at two levels: (1) an enterprise level and (2) a specific IT module level. the perceived value for ERP investments was consistently better explained at the specific IT module level.     

Test and evaluation of a solar powered gas turbine system

This paper describes the test and the results of a first prototype solar powered gas turbine system, installed during 2002 in the CESA-1 tower facility at Plataforma Solar de Almería (PSA) in Spain. The main goals of the project were to develop a solar receiver cluster able to provide pressurized air of 1000 °C and solve the problems arising from the coupling of the receivers with a conventional gas turbine to demonstrate the operability of the system. The test set-up consists of the heliostat field of the CESA-1 facility providing the concentrated solar power, a pressurized solar receiver cluster of three modules of 400 kWth each which convert the solar power into heat, and a modified helicopter engine (OST3) with a generator coupled to the grid. The first test phase at PSA started in December 2002 with the goal to reach a temperature level of 800 °C at the combustor air inlet by the integration of solar energy. This objective was achieved by the end of this test phase in March 2003, and the system could be operated at 230 kWe power to grid without major problems. In the second test phase from June 2003 to August 2003 the temperature level was increased to almost 1000 °C. The paper describes the system configuration, the component efficiencies and the operation experiences of the first 100 h of solar operation of this very successful first test of a solar operated Brayton gas turbine system.