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排序方式: 共有1140条查询结果,搜索用时 453 毫秒
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Pierre Santucci Christina Dedaki Alexandros Athanasoulis Laura Gallorini Anaïs Munoz Dr. Stéphane Canaan Dr. Jean-François Cavalier Dr. Victoria Magrioti 《ChemMedChem》2019,14(3):349-358
In the quest for new antibacterial agents, a series of novel long- and medium-chain mono- and disubstituted β-lactones was developed. Their activity against three pathogenic mycobacteria—M. abscessus, M. marinum, and M. tuberculosis—was assessed by the resazurin microtiter assay (REMA). Among the 16 β-lactones synthesized, only 3-hexadecyloxetan-2-one (VM005) exhibited promising activity against M. abscessus, whereas most of the β-lactones showed interesting activities against M. marinum, similar to that of the classical antibiotic, isoniazid. Regarding M. tuberculosis, six compounds were found to be active against this mycobacterium, with β-lactone VM008 [trans-(Z)-3-(hexadec-7-en-1-yl)-4-propyloxetan-2-one] being the best growth inhibitor. The promising antibacterial activities of the best compounds in this series suggest that these molecules may serve as leads for the development of much more efficient antimycobacterial agents. 相似文献
3.
Evaluation of the effect of processing on cocoa polyphenols: antiradical activity,anthocyanins and procyanidins profiling from raw beans to chocolate 下载免费PDF全文
Matteo Bordiga Monica Locatelli Fabiano Travaglia Jean Daniel Coïsson Giuseppe Mazza Marco Arlorio 《International Journal of Food Science & Technology》2015,50(3):840-848
The content and composition of anthocyanins and procyanidins in fermented cocoa beans (from different geographic origins: Ecuador, Cameroon, Ivory Coast, Ghana and Nigeria), roasted nibs, cocoa mass and chocolate were determined, beside the determination of the total antiradical capacity. Concerning geographic origin, cocoa beans and processed products from Ecuador showed the highest levels of anthocyanins, followed by Nigeria and Cameroon. Generally, as cocoa beans were further processed, the levels of anthocyanins and flavan‐3‐ols decreased. The largest observed losses of phenolics occurred during roasting. A progressive decreasing trend in polyphenol concentration was observed in the other processed samples as well. Despite the original content of polyphenols in raw cocoa beans, technological processes imply a significant impact on cocoa quality, confirming the need of specific optimisation to obtain high value chocolate. 相似文献
4.
M. F. Sorokïna O. M. Kanunnikova F. Z. Gil'mutdinov V. I. Kozhevnikov 《Glass and Ceramics》1996,53(1-2):11-13
The method of x-ray electron spectroscopy is used to investigate lead silicatexPbO(1 -x) · SiO2 (x - 0.3, 0.4, 0.5, 0.55, 0.667) glasses. The concentration dependences of the spectra of inner Pb4f, Si2p, and Ols levels led to the conclusion that for low contents of PbO, lead is present in the glass in the form of modifying ions, whereas in high concentrations, it plays the role of glass former. Restructuring in the glass occurs for about 50% molar concentration of PbO. The Pb - O bond in the glass is more ionic than in PbO. With an increase in the PbO content in the glass, the Pb - O bond becomes closer to that of lead monoxide, i.e., is more covalent. 相似文献
5.
Nguyen-Huy Dung Pardo Marie-Paule Dogguy.Smiri Leïla 《Materials Research Bulletin》1982,17(3):293-300
The Mn0.23Ga1.85S3 phase belongs to the solid solution , stable at low temperature in the Ga2S3MnS system. It is hexagonal superstructure of the wurtzite, with the Ga2S3α′ type (; Z = 6; space groupe P61 or P65). Its crystal structure has been refined by the least squares method to a final R = 0.06 with 323 independant reflections. This structure is closely related to Ga2S3 α described by Hahn and Frank, and differs only by the partial occupation of the vacant metal site of Ga2S3 by Mn atoms in statistical disorder. 相似文献
6.
In this paper we consider two performance modelling techniques from the perspectives of model construction, generation of
an underlying continuous time Markov process, and the potential for reduction in the Markov process. Such careful comparison
of modelling techniques allows us to appreciate the strengths and weaknesses of different approaches, and facilitates cross-fertilization
between them. In the present case we take a characteristic of one formalism, functional rates in Stochastic Automata Networks,
and introduce it to the other formalism, Performance Evaluation Process Algebra. We investigate the benefits of this cross-fertilization,
particularly from the perspectives of Markov process generation and reduction. 相似文献
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Summary Systems of poly(ethylene oxide)/polystyrene and of poly(ethylene oxide)/poly(styrene-co-acrylic acid) of different ratios
were studied by inverse gas chromatography using benzene and n-decane as molecule probes and by viscosimetry in tetrahydrofuran.
The transition temperatures as shown in the retention diagrams and the interaction parameters as determined by inverse gas
chromatography and by viscosimetry showed that whereas poly(ethylene oxide) is incompatible with polystyrene, the introduction
of amounts of acrylic acid groups into polystyrene chains by free radical copolymerization led to compatible systems of the
acidic copolymer with the poly(ethylene oxide). 相似文献
9.
Adaptive filtering gives simple iterative methods for extracting a useful signal by linearly filtering an observation correlated with this useful signal. When the observation contains past values of the filter output—as is the case for a recursive structure— the adaptive filter is a non linear operator which can generate complex behaviours even though adaptation is a standard derivative of the gradient algorithm. Such behaviours are observed in a particular case : theArma adaptive prediction with a sinusoidal input. A slow adaptation speed involves a quasi-periodic behaviour due to the locally unstable character of the predictor. This phenomenon called selfstabilization persists as the adaptation speed increases. Its study is more complicated : the behaviour becomes chaotic. As an illustration, the digitization of telephone signals throughArma adaptive prediction shows the necessity of controlling the qualitative behaviour of the adaptive filtering solutions. 相似文献
10.
Fouad Laoutid Henri Vahabi Elnaz Movahedifar Pascal Laheurte Christelle Vagner Marianne Cochez Loïc Brison Mohammad Reza Saeb 《乙烯基与添加剂工艺杂志》2021,27(2):264-274
In this study, the effect of the chemical nature of different calcium (Ca)-based minerals as flame retardant additives in combination with ammonium polyphosphate (APP), in 1:1 proportions, on the flame retardancy behavior and performance of ethylene vinyl acetate copolymer was discussed. Combining APP with partly and completely hydrated calcium oxide led to superior flame-retardant function detected in mass loss calorimeter measurements with respect to the corresponding system containing carbonated calcium. This privileged character was attributed to the higher reactivity of hydrated Ca-based fillers toward APP in comparison with Ca carbonate, which induced the formation of an intumescent residue. The difference between reactivity potential of hydrated and dry Ca was demonstrated by the newly formed thermally stable species, and further evidenced by thermogravimetric analysis performed on APP/fillers blends. Moreover, the presence of more crystalline domains in the Ca/phosphorus-based compounds was evidenced by XRD analysis of the mass loss calorimeter test residues. The results of this work highlight the role of blend additive systems on the performance of flame retardancy of polymer materials. 相似文献