Heifers with positive genetic merit for fertility traits reach puberty earlier and have a greater pregnancy rate than heifers with negative genetic merit for fertility traits

This study investigated the hypothesis that dairy heifers divergent in genetic merit for fertility traits differ in the age of puberty and reproductive performance. New Zealand's fertility breeding value (FertBV) is the proportion of a sire's daughters expected to calve in the first 42 d of the seasonal calving period. We used the New Zealand national dairy database to identify and select Holstein-Friesian dams with either positive (POS, +5 FertBV, n = 1,334) or negative FertBV (NEG, ?5% FertBV, n = 1,662) for insemination with semen from POS or NEG FertBV sires, respectively. The resulting POS and NEG heifers were predicted to have a difference in average FertBV of 10 percentage points. We enrolled 640 heifer calves (POS, n = 324; NEG, n = 316) at 9 d ± 5.4 d (± standard deviation; SD) for the POS calves and 8 d ± 4.4 d old for the NEG calves. Of these, 275 POS and 248 NEG heifers were DNA parent verified and retained for further study. The average FertBV was +5.0% (SD = 0.74) and ?5.1% (SD = 1.36) for POS and NEG groups, respectively. Heifers were reared at 2 successive facilities as follows: (1) calf rearing (enrollment to ～13 wk of age) and (2) grazier, after 13 wk until 22 mo of age. All heifers wore a collar with an activity sensor to monitor estrus events starting at 8 mo of age, and we collected weekly blood samples when individual heifers reached 190 kg of body weight (BW) to measure plasma progesterone concentrations. Puberty was characterized by plasma progesterone concentrations >1 ng/mL in at least 2 of 3 successive weeks. Date of puberty was defined when the first of these samples was >1 ng/mL. Heifers were seasonally bred for 98 d starting at ～14 mo of age. Transrectal ultrasound was used to confirm pregnancy and combined with activity data to estimate breeding and pregnancy dates. We measured BW every 2 wk, and body condition and stature at 6, 9, 12, and 15 mo of age. The significant FertBV by day interaction for BW was such that the NEG heifers had increasingly greater BW with age. This difference was mirrored with the significant FertBV by month interaction for average daily gain, with the NEG heifers having a greater average daily gain between 9 and 18 mo of age. There was no difference in heifer stature between the POS and NEG heifers. The POS heifers were younger and lighter at puberty, and were at a lesser mature BW, compared with the NEG heifers. As a result, 94 ± 1.6% of the POS and 82 ± 3.2% of the NEG heifers had reached puberty at the start of breeding. The POS heifers were 20% and 11% more likely to be pregnant after 21 d and 42 d of breeding than NEG heifers (relative risk = 1.20, 95% confidence interval of 1.03–1.34; relative risk = 1.11, 95% confidence interval of 1.01–1.16). Results from this experiment support an association between extremes in genetic merit for fertility base on cow traits and heifer reproduction. Our results indicate that heifer puberty and pregnancy rates are affected by genetic merit for fertility traits, and these may be useful phenotypes for genetic selection.     

Ambient fine particulate air pollution triggers ST-elevation myocardial infarction, but not non-ST elevation myocardial infarction: a case-crossover study

Background

We and others have shown that increases in particulate air pollutant (PM) concentrations in the previous hours and days have been associated with increased risks of myocardial infarction, but little is known about the relationships between air pollution and specific subsets of myocardial infarction, such as ST-elevation myocardial infarction (STEMI) and non ST-elevation myocardial infarction (NSTEMI).

Methods

Using data from acute coronary syndrome patients with STEMI (n?=?338) and NSTEMI (n?=?339) and case-crossover methods, we estimated the risk of STEMI and NSTEMI associated with increased ambient fine particle (<2.5 um) concentrations, ultrafine particle (10-100 nm) number concentrations, and accumulation mode particle (100-500 nm) number concentrations in the previous few hours and days.

Results

We found a significant 18% increase in the risk of STEMI associated with each 7.1 μg/m³ increase in PM_2.5 concentration in the previous hour prior to acute coronary syndrome onset, with smaller, non-significantly increased risks associated with increased fine particle concentrations in the previous 3, 12, and 24 hours. We found no pattern with NSTEMI. Estimates of the risk of STEMI associated with interquartile range increases in ultrafine particle and accumulation mode particle number concentrations in the previous 1 to 96 hours were all greater than 1.0, but not statistically significant. Patients with pre-existing hypertension had a significantly greater risk of STEMI associated with increased fine particle concentration in the previous hour than patients without hypertension.

Conclusions

Increased fine particle concentrations in the hour prior to acute coronary syndrome onset were associated with an increased risk of STEMI, but not NSTEMI. Patients with pre-existing hypertension and other cardiovascular disease appeared particularly susceptible. Further investigation into mechanisms by which PM can preferentially trigger STEMI over NSTEMI within this rapid time scale is needed.     

Implications of failure criteria choices on the rapid concept design of composite grillage structures using multiobjective optimisation

Grillage topologies are commonly used in many composite structural applications to produce low mass designs that have a high stiffness. While composite failure criteria are being compared in many different simple structures, for example plates and tubes, literature must also compare more complicated applications, including grillages, as there are distinct differences in behaviour. This paper therefore performs analysis of grillage structures with more up to date failure criteria, taken from the world wide failure exercise, than previously investigated. The grillage theory selected is that of Navier theory with elastic equivalent properties due to its low computational expense for use with a genetic algorithm to optimise a composite structure. The results take an example from leisure boatbuilding showing the grillages produced from the different limit states, comparing the cost and mass. The final results show that the method allows a rapid analysis of grillages and that the selection of the limit state has an important effect on the optimised grillage topology.     

Atomic Afterimages

This article examines the recirculation of Robert Del Tredici's photographs of the Cold War nuclear weapons complex. Originally published in his groundbreaking book, At Work in the Fields of the Bomb (1987), a number of Del Tredici's photographs have been republished in a series of post‐Cold War US Department of Energy reports. The article examines the post‐Cold War circulation of Del Tredici's images in these official government reports and analyzes shifts in their meaning across different historical periods. Ultimately, this paper raises questions about the critical stance of Del Tredici's photographs as they are republished in government reports and examines ways in which the meaning of his photographs responds to both Cold War and post‐Cold War contexts.     

Effect of waxy flour blends on dough rheology and bread quality

Although much research has been conducted on wheat flour dough rheology, the principal focus has been the role of the protein fraction. Starch is the main component of flour and plays a key role in dough dynamic properties, particularly during heating. This study assesses the effect of two different waxy flours, a durum and a bread wheat, and their blends with commercial bakers' flour on dough rheology during heating with a concurrent investigation into baking performance. Both waxy flour blends produced similar effects on dough rheological behaviour despite differences in protein content, acting to delay gelatinisation and reduce storage modulus. The main effects in bread were to increase loaf expansion during baking and reduce loaf firmness. It is postulated these effects are largely water mediated, with the higher swelling ability of the waxy starch granules reducing overall water availability and driving complete gelatinisation to higher temperatures.     

3D Printed Anatomical Nerve Regeneration Pathways

A 3D printing methodology for the design, optimization, and fabrication of a custom nerve repair technology for the regeneration of complex peripheral nerve injuries containing bifurcating sensory and motor nerve pathways is introduced. The custom scaffolds are deterministically fabricated via a microextrusion printing principle using 3D models, which are reverse engineered from patient anatomies by 3D scanning. The bifurcating pathways are augmented with 3D printed biomimetic physical cues (microgrooves) and path‐specific biochemical cues (spatially controlled multicomponent gradients). In vitro studies reveal that 3D printed physical and biochemical cues provide axonal guidance and chemotractant/chemokinetic functionality. In vivo studies examining the regeneration of bifurcated injuries across a 10 mm complex nerve gap in rats showed that the 3D printed scaffolds achieved successful regeneration of complex nerve injuries, resulting in enhanced functional return of the regenerated nerve. This approach suggests the potential of 3D printing toward advancing tissue regeneration in terms of: (1) the customization of scaffold geometries to match inherent tissue anatomies; (2) the integration of biomanufacturing approaches with computational modeling for design, analysis, and optimization; and (3) the enhancement of device properties with spatially controlled physical and biochemical functionalities, all enabled by the same 3D printing process.     

Curiosity adapted the cat: The role of trait curiosity in newcomer adaptation.

Using longitudinal data from 123 newcomers across 12 telemarketing organizations, we examined the role of 2 forms of trait curiosity (specific and diversive) as antecedents of proximal adaptation behaviors (information seeking and positive framing) and more distal, in-role and extra-role behaviors (job performance and taking charge). Results suggest that specific curiosity predicts information seeking behaviors, whereas diversive curiosity promotes positive framing. Results also support the relationship between positive framing and performance and the extra-role behavior of taking charge. Overall, the study validates the role of curiosity as a multifaceted individual difference that serves as an antecedent to newcomer adaptation. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Colloidal Stability & Conformational Changes in β-Lactoglobulin: Unfolding to Self-Assembly

A detailed understanding of the mechanism of unfolding, aggregation, and associated rheological changes is developed in this study for β-Lactoglobulin at different pH values through concomitant measurements utilizing dynamic light scattering (DLS), optical microrheology, Raman spectroscopy, and differential scanning calorimetry (DSC). The diffusion interaction parameter k_D emerges as an accurate predictor of colloidal stability for this protein consistent with observed aggregation trends and rheology. Drastic aggregation and gelation were observed at pH 5.5. Under this condition, the protein’s secondary and tertiary structures changed simultaneously. At higher pH (7.0 and 8.5), oligomerizaton with no gel formation occurred. For these solutions, tertiary structure and secondary structure transitions were sequential. The low frequency Raman data, which is a good indicator of hydrogen bonding and structuring in water, has been shown to exhibit a strong correlation with the rheological evolution with temperature. This study has, for the first time, demonstrated that this low frequency Raman data, in conjunction with the DSC endotherm, can be been utilized to deconvolve protein unfolding and aggregation/gelation. These findings can have important implications for the development of protein-based biotherapeutics, where the formulation viscosity, aggregation, and stability strongly affects efficacy or in foods where protein structuring is critical for functional and sensory performance.     

Energy efficiency and renewable energy under extreme conditions: Case studies from Antarctica

This article showcases a range of small and large scale energy efficiency and renewable energy deployments at Antarctic research stations and field camps. Due to the cold and harsh environment, significant amounts of fuel are needed to support humans working and living in Antarctica. The purchase, transportation and storage of large amounts of fossil fuel entail significant economic costs and environmental risks and have motivated developments in energy efficiency and renewable energy deployment. Over the past three decades, improved building design, behavioral change, cogeneration, solar collectors, solar panels and wind turbines have been found to be effective in Antarctica, demonstrating that harsh environmental conditions and technological barriers do not have to limit the deployment of energy efficiency and renewable energy. The ambition to run entire stations or field camps on 100% renewable energy is increasingly common and feasible. While the power requirements of Antarctic research stations are small compared to urban installations on other continents, these case studies clearly demonstrate that if energy efficiency and renewable energy can be deployed widely on the coldest, darkest and most remote continent of the world, their deployment should be more widespread and encouraged on other continents.     

A semantic analysis approach for assessing professionalism using free-form text entered online

This paper presents the results of an experimental study to measure professionalism for the purpose of assessing a professional development program. Soft skills such as professionalism are increasingly recognized as important, yet measuring and assessing these skills, typically best acquired experientially, has remained challenging. Following established research, we conceptualize professionalism as a construct with the dimensions of autonomy, commitment, belief in public service, self-regulation, and the use of a professional organization as a major referent. We demonstrate how these dimensions can be expressed and the professionalism of free-form text responses measured. These responses are reflections submitted online by participants in a professional development program for undergraduate business majors known as the Management Achievement Program (MAP). Latent semantic analysis is employed to measure the professionalism of these responses and to assess MAP along each of the five dimensions. The method demonstrated in this paper has several advantages over existing methods for assessment, which can be costly, require considerable time and training, and are often tied to subjective interpretation. The method demonstrated here is suitable for replication that leads to continuous improvement by “closing the loop.”