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1.
JM Rumsey BC Donohue DR Brady K Nace JN Giedd P Andreason 《Canadian Metallurgical Quarterly》1997,54(12):1481-1489
The influence of ionic strength and composition on the binding and inhibition of human leukocyte elastase by glycosaminoglycans with variable degree and position of sulfation was investigated. The kinetic mechanism of inhibition had a hyperbolic, mixed-type character with a competitive component that was promoted by low ionic strength, reduced by phosphate ions, and which also depended on the substrate and glycosaminoglycan structure. Enzyme binding was a cooperative phenomenon that varied with ionic strength and composition. The inhibition patterns correlated with the cationic character of elastase and with the distribution of arginines on its molecular surface, most notably with residues located in the vicinity of the substrate binding region. The order of affinity for elastase binding was chondroitin 4-sulfate < chondroitin 6-sulfate < dermatan sulfate, iduronate-containing derivatives being superior with respect to the glucuronate-containing counterparts. Additional sulfation at both the 4- and 6- positions or at the N- and 4-positions of the N-acetylgalactosamine moiety decidedly improved the inhibitory efficiency. The results highlight a fundamental physiological role of enzyme-glycosaminoglycan interactions. In the azurophil granule of the human polymorphonuclear neutrophil, elastase and other enzymes are bound to a matrix of chondroitin 4-sulfate because this is the only glycosaminoglycan that simultaneously offers good binding for enzyme compartmentalization together with prompt release from the bound state at the onset of phagocytosis. 相似文献
2.
ST O'Sullivan GT McGreal A Lyons L Burke JG Geoghegan MP Brady 《Canadian Metallurgical Quarterly》1994,47(9):851-852
A case of histologically confirmed Paget's disease of the breast in a 72 year old man, without underlying breast carcinoma, is reported. This report raises questions about the pathogenesis of this condition and suggests that Paget's disease is an independent, intraepidermal carcinoma rather than a direct extension of intraductal carcinoma of the breast to the nipple and areola. 相似文献
3.
Michael Brady 《Energy》1985,10(10):1113-1118
Current energy policies have severely eroded the earth's natural atmospheric waste-receptor capacity. Present acid rain concentrations may require a switch to an alternative energy-resource emphasis. This policy recommendation follows directly from a deductive control theory demonstration which shows that, if fossil-fuel use is continued at present rates, then there is an ever-increasing risk of a man-made environmental crisis of uncertain nature and scope. 相似文献
4.
This paper discusses the structure and empirical estimation of the County Employment Forecasting System (CEFS), a system used to forecast employment for 32 sectors for each one of the nine counties of the San Francisco Bay Region. CEFS differs in several aspects from the majority of models which attempt to simulate employment change at the subregional level; it explicitly considers the relationships between sectors, it accounts for the interactions between counties, and can provide a set of county forecasts which are consistent with the overall regional projections. 相似文献
5.
6.
This study was conducted in order to determine the effects of body position on integrated electromyographic (IEMG) activity of sternocleidomastoid and masseter muscles in 17 patients with myogenic cranio-cervical-mandibular dysfunction. EMG recordings at rest and during swallowing of saliva and maximal voluntary clenching were performed by placing surface electrodes on the sternocleidomastoid and masseter muscles (contralateral to the habitual side of sleeping of each patient), in the following body positions: standing, seated, supine, and lateral decubitus position. Significant higher EMG activities were recorded in the sternocleidomastoid muscle in the lateral decubitus position and in the supine position (except during swallowing), whereas a significant higher EMG activity was recorded in the masseter muscle during maximal voluntary clenching in standing and seated positions. The EMG pattern observed suggests that the presence of parafunctional habits and body position could be closely correlated with the clinical symptomatology in the sternocleidomastoid and masseter muscles at wakening and during waking hours, respectively, in patients with myogenic cranio-cervical-mandibular dysfunction. 相似文献
7.
Determination of temperatures associated with room fires provides a means of assessing an important aspect of fire hazard: the likelihood of the occurrence of flashover. Layer temperatures in excess of 600°C have been associated with the occurrence of flashover. A data correlation has previously been presented to estimate layer temperatures for fires burning in the center of rooms. For fires in corners and along walls, restricted entrainment results in higher layer temperatures than predicted by the previous correlation. Modification factors for the previous correlation are developed to extend its applicability to wall and corner burning geometries. The present analysis suggests that a fire in a corner may cause flashover with only half the heat release rate necessary for a fire burning in the center of a room.
Reference: Frederick Mowrer and Robert Williamson, Estimating Room Temperatures from Fires along Walls and in Corners,Fire Technology, Vol. 23, May 1987, pp. 133–145. 相似文献
8.
Methyl 8-[2-(cis-pent-2′-enyl)-3-oxo-cis-cyclopent-4-enyl] octanoate (I) is the methyl ester of a cyclic fatty acid synthesized enzymically from an incubation of
linolenic acid with an extract of flaxseed (Linum usitatissimum L.). A proposed trivial name for I is methyl 12-oxo-cis-10, 15-phytodienoate (12-oxo-PDA). The evidence presented indicated that compound I has thecis configuration of the carbon chains with respect to the cyclopentenone ring. Treatment with acid, base, or heat isomerized
I to a second product (II) that has thetrans configuration of the carbon chains. Prolonged heat treatment of II yielded a third cyclic product, methyl 12-oxo-9(13),cis-15-phytodienoate (III). 相似文献
9.
3D Motion recovery via affine Epipolar geometry 总被引:10,自引:6,他引:4
Larry S. Shapiro Andrew Zisserman Michael Brady 《International Journal of Computer Vision》1995,16(2):147-182
Algorithms to perform point-based motion estimation under orthographic and scaled orthographic projection abound in the literature. A key limitation of many existing algorithms is that they operate on the minimum amount of data required, often requiring the selection of a suitable minimal set from the available data to serve as a local coordinate frame. Such approaches are extremely sensitive to errors and noise in the minimal set, and forfeit the advantages of using the full data set. Furthermore, attention is seldom paid to the statistical performance of the algorithms.We present a new framework that allowsall available features to be used in the motion computations, without the need to select a frame explicitly. This theory is derived in the context of theaffine camera, which preserves parallelism and generalises the orthographic, scaled orthographic and para-perspective models. We define the affine epipolar geometry for two such cameras, giving the fundamental matrix in this case. The noise resistant computation of the epipolar geometry is discussed, and a statistical noise model constructed so that confidence in the results can be assessed.The rigid motion parameters are then determineddirectly from the epipolar geometry, using the novel rotation representation of Koenderink and van Doorn (1991). The two-view partial motion solution comprises the scale factor between views, the projection of the 3D axis of rotation and the cyclotorsion angle, while the addition of a third view allows the true 3D rotation axis to be computed (up to a Necker reversal). The computed uncertainties in these parameters permit optimal estimates to be obtained over time by means of a linear Kalman filter. Our theory extends work by Huang and Lee (1989), Harris (1990), and Koenderink and van Doorn (1991), and results are given on both simulated and real data. 相似文献
10.
S Brady CM Hiam R Saemann L Humbert MZ Fleming K Dawkins-Brickhouse 《Canadian Metallurgical Quarterly》1996,32(6):573-578
The treatment of "dual diagnosis", co-occurring substance abuse and mental illness, calls for addressing two serious and often confounding problems. The authors introduce an expanded version of the transtheoretical model of change as formulated by J.O. Prochaska and C.C. DiClemente, and suggest that this new version offers a pragmatic approach to the conceptualization and treatment of dual diagnosis. The potential utility of the treatment model is presented through the authors' experiences in working with inner-city, chronic mentally ill individuals with substance abuse problems. Practical guidelines for dual diagnosis group therapy are discussed. 相似文献