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排序方式: 共有85条查询结果,搜索用时 15 毫秒
1.
Roy Satyabrata Shrivastava Manu Pandey Chirag Vinodkumar Nayak Sanjeet Kumar Rawat Umashankar 《Multimedia Tools and Applications》2021,80(21-23):31529-31567
Multimedia Tools and Applications - Present era is marked by exponential growth in transfer of multimedia data through internet. Most of the Internet-of-Things(IoT) applications send images to... 相似文献
2.
Wireless sensor networks (WSNs) are a kind of communication networks having independent sensor nodes that form multi-hop ad hoc network to transfer data. In the past few years, various transport control protocols in wireless sensor networks (WSNs) have been developed and proposed in the literature. In this paper, we have analyzed pump slowly, fetch quickly (PSFQ) protocol and presented an improved transport layer protocol for wireless sensor networks. The improved protocol has been analyzed based on various factors such as average latency and average error tolerance and it is found that the proposed protocol is better than PSFQ in terms of these factors. 相似文献
3.
Chirag Desai 《Drug development and industrial pharmacy》2015,41(10):1589-1607
Context: The clinical applications of cilostazol (CLZ) are limited by its low aqueous solubility (<5?µg/ml) and high biovariability.Objective: The aim of this study was to enhance the solubility of CLZ by forming inclusion complexes (ICs) with beta cyclodextrin (β-CD) and formulating them into oral disintegrating tablets.Methods: Phase solubility study of CLZ with β-CD was performed in water. Job’s plot was constructed to determine the stoichiometry of ICs. ICs, prepared by spray-drying technique, were characterized using Fourier transform infrared spectroscopy, differential scanning calorimetry, hot stage microscopy, powder X-ray diffraction and nuclear magnetic resonance. Molecular modeling studies were performed to understand the mode of interaction of CLZ with β-CD. The formulation process was undertaken using a reproducible design of experiment generated model, attained by variation of diluents and disintegrants at three levels. Tablets were evaluated for drug content, hardness, friability, disintegration time (DT), wetting time (WT) and dissolution profiles.Results and discussion: Phase solubility studies suggested an AL type curve with stability constant (Ks) of 922.52?M?1. Job’s plot revealed 1:2 stoichiometry. All analytical techniques confirmed inclusion complexation. Molecular modeling revealed dispersive van der Waals interaction energy as a major contributor for stabilization of complex. The spray-dried complexes showed higher solubility and faster dissolution compared to plain CLZ. The optimized formulation showed DT of 11.1?±?0.8?s, WT of 8.7?±?0.9?s and almost complete dissolution of CLZ in 15?min.Conclusion: The prepared tablets with low DT and fast dissolution will prove to be a promising drug delivery system with improved bioavailability and better patient compliance. 相似文献
4.
Chirag Nagda Narendra Prabhudas Chotai Upendra Patel Sandip Patel Tejal Soni Prateek Patel 《Drug development and industrial pharmacy》2013,39(10):1155-1166
Objective: Microencapsulation of the anti-inflammatory drug aceclofenac (ACE) was investigated as a means of controlling drug release and minimizing or eliminating local side effects. Method: Microspheres were prepared by a spray-drying technique using solutions of ACE and three polymers, namely, carbopol, chitosan, and polycarbophil, in different weight ratios. Results: The spray-dried mucoadhesive microspheres were characterized in terms of shape (scanning electron microscope), size (6.60–8.40 μm), production yield (34.10–55.62%), and encapsulation efficiency (58.14–90.57%). In vitro release studies were performed in phosphate buffer (pH 6.8) up to 10 hours. The spray-drying process of solutions of ACE with polymeric blends can give prolonged drug release. The in vitro release data were well fit into Higuchi and Korsmeyer–Peppas model and followed Fickian diffusion mechanism. In vivo data showed that the administration of ACE in polymeric microspheres prevented the gastric side effects. Conclusion: The formulations here described can be proposed for the oral administration of nonsteroidal anti-inflammatory drugs with minimal side effects on gastric mucosa. 相似文献
5.
Ashok Mahajan Naazneen Surti Pooja Koladiya 《Drug development and industrial pharmacy》2018,44(3):463-471
The aim of the present study was to improve the dissolution and flow properties of lurasidone hydrochloride (LH) by solid dispersion adsorbate (SDA) technique. Solid dispersions (SDs) of LH were prepared by fusion method using Poloxamer P188. The melt dispersion was adsorbed onto the porous carrier Florite (calcium silicate). A 32 factorial design was employed to quantify the effect of two independent variables, namely ratio of carrier (Poloxamer 188) and LH in SD and ratio of adsorbent (Florite) to SD. SDA granules of LH were studied for flow properties and characterized using differential scanning calorimetry, scanning electron microscopy, and X-ray diffraction. Tablets of optimized composition of SDA granules (equivalent to 20?mg of drug) and plain tablets were prepared by direct compression method. The dissolution studies were carried out in Mcllvaine buffer (pH 3.8) as per USFDA guidelines and characterized for parameters such as percent dissolution efficiency, t50, and Q30. Tablets prepared from SDA granules showed almost four-fold increase in cumulative percentage drug release as compared to tablets prepared from plain LH. The value of dissolution efficiency was enhanced from 49.60% for plain tablets to 94.15% for SDA tablets. SDA granules did not show any change in drug release and X-ray diffraction pattern after storage at 40?°C/75% of RH for 3?months, which confirms that Florite prevented conversion of drug from amorphous form to crystalline form improving physical stability of the amorphous state of LH. 相似文献
6.
The present article describes the synthesis of silver nanoparticles (SNPs) impregnatated crosslinked beaded polystyrene/polyamidoxime (PSD/PAMD) interpenetrating polymer networks (IPNs). The developed SNPs‐IPNs were tested for the antibacterial activity for water purification. Intially, the crosslinked beaded polystyrene/polyacrylonitrile (PSD/PAN) polymer was synthesized by radical sequential suspension polymerization method therafter, it has been converted into PSD/PAMD‐IPN comprising amidoxime group, which acts as capping agent to anchor the silver ions. The silver ions impregnated with PSD/PAMD‐IPN were converted into SNPs by chemical reduction methodology followed by stabilization without any deterioration or loss in polymer. IR and solid‐state 13C NMR spectra were use for the structural characterization of developed SNPs‐IPN, while morphological characterization was examined by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and X‐ray diffraction (XRD). The size of the SNPs formed with the networks were found less than 5 nm. The disinfection potential of SNPs‐IPN was evaluated by different antibacterial test. The bactericidal test of SNPs‐IPN revealed the promissing antibacterial efficieny with complete microbial inhibition within 4–6 h. The reusability of the SNPs‐IPN beads was also tested for its repeated use for industrial application. POLYM. COMPOS., 70–80, 2016. © 2014 Society of Plastics Engineers 相似文献
7.
本研究旨在确定影响空调办公建筑能耗的关键建筑设计变量。本研究基于热带气候条件下的新加坡进行。结合56个办公楼改造前后能源审计报告数据进行评估分析。从这些报告中提取的14个建筑变量的列表构成了超集。对这些数据进行系统分析,得出影响能耗和改造决策的关键变量。为此,利用k均值聚类确定了一个稳健的迭代过程。该过程对14个变量的所有组合进行了测试,以应对改造前后条件下的能源使用强度(EUI,kW·h/m~2·a)的变化。结果表明,最佳变量包括:1)总建筑面积(GFA);2)非空调能耗;3)冷却装置的平均效率;4)冷却装置的装机容量。这些信息可以用来探索需要改造的办公楼的节能潜力。由此产生的集群还可以用来根据改造前的条件和节能潜力来对建筑物进行基准测试。 相似文献
8.
O Klein GW Polack T Surti D Kegler-Ebo SO Smith D DiMaio 《Canadian Metallurgical Quarterly》1998,72(11):8921-8932
The bovine papillomavirus E5 protein is a small, homodimeric transmembrane protein that forms a stable complex with the cellular platelet-derived growth factor (PDGF) beta receptor through transmembrane and juxtamembrane interactions, resulting in receptor activation and cell transformation. Glutamine 17 in the transmembrane domain of the 44-amino-acid E5 protein is critical for complex formation and receptor activation, and we previously proposed that glutamine 17 forms a hydrogen bond with threonine 513 of the PDGF beta receptor. We have constructed and analyzed mutant E5 proteins containing all possible amino acids at position 17 and examined the ability of these proteins to transform C127 fibroblasts, which express endogenous PDGF beta receptor. Although several position 17 mutants were able to transform cells, mutants containing amino acids with side groups that were unable to participate in hydrogen bonding interactions did not form a stable complex with the PDGF beta receptor or transform cells, in agreement with the proposed interaction between position 17 of the E5 protein and threonine 513 of the receptor. The nature of the residue at position 17 also affected the ability of the E5 proteins to dimerize. Overall, there was an excellent correlation between the ability of the various E5 mutant proteins to bind the PDGF beta receptor, lead to receptor tyrosine phosphorylation, and transform cells. Similar results were obtained in Ba/F3 hematopoietic cells expressing exogenous PDGF beta receptor. In addition, treatment of E5-transformed cells with a specific inhibitor of the PDGF receptor tyrosine kinase reversed the transformed phenotype. These results confirm the central importance of the PDGF beta receptor in mediating E5 transformation and highlight the critical role of the residue at position 17 of the E5 protein in the productive interaction with the PDGF beta receptor. On the basis of molecular modeling analysis and the known chemical properties of the amino acids, we suggest a structural basis for the role of the residue at position 17 in E5 dimerization and in complex formation between the E5 protein and the PDGF beta receptor. 相似文献
9.
Imaging performance of A-PET: a small animal PET camera 总被引:6,自引:0,他引:6
Surti S Karp JS Perkins AE Cardi CA Daube-Witherspoon ME Kuhn A Muehllehner G 《IEEE transactions on medical imaging》2005,24(7):844-852
The evolution of positron emission tomography (PET) imaging for small animals has led to the development of dedicated PET scanner designs with high resolution and sensitivity. The animal PET scanner achieves these goals for imaging small animals such as mice and rats. The scanner uses a pixelated Anger-logic detector for discriminating 2 x 2 x 10 mm3 crystals with 19-mm-diameter photomultiplier tubes. With a 19.7-cm ring diameter, the scanner has an axial length of 11.9 cm and operates exclusively in three-dimensional imaging mode, leading to very high sensitivity. Measurements show that the scanner design achieves a spatial resolution of 1.9 mm at the center of the field-of-view. Initially designed with gadolinium orthosilicate but changed to lutetium- yttrium orthosilicate, the scanner now achieves a sensitivity of 3.6% for a point source at the center of the field-of-view with an energy window of 250-665 keV. Iterative image reconstruction, together with accurate data corrections for scatter, random, and attenuation, are incorporated to achieve high-quality images and quantitative data. These results are demonstrated through our contrast recovery measurements as well as sample animal studies. 相似文献
10.
Sharma Dileepkumar Ramlal Jainy Sachdeva Chirag Kamal Ahuja Niranjan Khandelwal 《International journal of imaging systems and technology》2019,29(2):146-160
This research proposes an improved hybrid fusion scheme for non-subsampled contourlet transform (NSCT) and stationary wavelet transform (SWT). Initially, the source images are decomposed into different sub-bands using NSCT. The locally weighted sum of square of the coefficients based fusion rule with consistency verification is used to fuse the detailed coefficients of NSCT. The SWT is employed to decompose approximation coefficients of NSCT into different sub-bands. The entropy of square of the coefficients and weighted sum-modified Laplacian is employed as the fusion rules with SWT. The final output is obtained using inverse NSCT. The proposed research is compared with existing fusion schemes visually and quantitatively. From the visual analysis, it is observed that the proposed scheme retained important complementary information of source images in a better way. From the quantitative comparison, it is seen that this scheme gave improved edge information, clarity, contrast, texture, and brightness in the fused image. 相似文献