A Systematic Review and Meta-Analysis of Pharmacogenetic Studies in Patients with Chronic Kidney Disease

Chronic kidney disease (CKD) is an important global public health problem due to its high prevalence and morbidity. Although the treatment of nephrology patients has changed considerably, ineffectiveness and side effects of medications represent a major issue. In an effort to elucidate the contribution of genetic variants located in several genes in the response to treatment of patients with CKD, we performed a systematic review and meta-analysis of all available pharmacogenetics studies. The association between genotype distribution and response to medication was examined using the dominant, recessive, and additive inheritance models. Subgroup analysis based on ethnicity was also performed. In total, 29 studies were included in the meta-analysis, which examined the association of 11 genes (16 polymorphisms) with the response to treatment regarding CKD. Among the 29 studies, 18 studies included patients with renal transplantation, 8 involved patients with nephrotic syndrome, and 3 studies included patients with lupus nephritis. The present meta-analysis provides strong evidence for the contribution of variants harbored in the ABCB1, IL-10, ITPA, MIF, and TNF genes that creates some genetic predisposition that reduces effectiveness or is associated with adverse events of medications used in CKD.     

Meeting the challenge of water sustainability: The role of process systems engineering

This white paper is the result of discussions during the FIPSE-4 conference ( http://fi-in-pse.org ) in June 2018. It aims to highlight open problems and provide directions for future research in the area of water with emphasis on its agricultural usages. Some of the open problems discussed are: (a) the use of ecosystems as unit operations to understand their role in providing freshwater and in cleaning polluted water; (b) consideration of interactions and independencies between flows of water and other resources, such as food, energy, materials, ecosystem services, and environmental emissions; (c) challenges in modeling, sensing, and closed-loop control in precision irrigation. In particular, the development of agro-hydrological models that balance computing speed versus solution details and accuracy: (d) The use of state and parameter estimation approaches, through field measurements, to obtain soil moisture levels accurately; and (e) decision support systems to administer water and nutrient needs for optimum yields of agricultural products.     

Reoptimization framework and policy analysis for maritime inventory routing under uncertainty

We study a maritime inventory routing problem, in which shipments between production and consumption nodes are carried out by a fleet of vessels. The vessels have specific capacities and can be chartered under different agreements. The inventory levels of all consumption nodes and some production nodes should be maintained within specified bounds; for the remaining production nodes, orders should be picked up within pre-defined time windows. We propose a discrete-time mixed-integer programming model. In the face of new information and uncertainty, this optimization model has to be re-solved, as the horizon is rolled forward. We discuss how to account for different sources of uncertainty. We present a rolling-horizon reoptimization framework that allows us to study different policies that impact the quality of the implemented solution, so we can identify the optimal set of policies.     

Nitrogen dynamics during the seed-filling period in safflower under dryland Mediterranean conditions

Nutrient Cycling in Agroecosystems - Precise knowledge of safflower (Carthamus tinctorius L.) nitrogen (N) dynamics is essential to optimize crop nutrition and minimize environmental impacts of...     

Scalable Distributed Sensor Fault Diagnosis for Smart Buildings

The enormous energy use of the building sector and the requirements for indoor living quality that aim to improve occupants’ productivity and health, prioritize Smart Buildings as an emerging technology. The Heating, Ventilation and Air-Conditioning (HVAC) system is considered one of the most critical and essential parts in buildings since it consumes the largest amount of energy and is responsible for humans comfort. Due to the intermittent operation of HVAC systems, faults are more likely to occur, possibly increasing eventually building’s energy consumption and/or downgrading indoor living quality. The complexity and large scale nature of HVAC systems complicate the diagnosis of faults in a centralized framework. This paper presents a distributed intelligent fault diagnosis algorithm for detecting and isolating multiple sensor faults in large-scale HVAC systems. Modeling the HVAC system as a network of interconnected subsystems allows the design of a set of distributed sensor fault diagnosis agents capable of isolating multiple sensor faults by applying a combinatorial decision logic and diagnostic reasoning. The performance of the proposed method is investigated with respect to robustness, fault detectability and scalability. Simulations are used to illustrate the effectiveness of the proposed method in the presence of multiple sensor faults applied to a 83-zone HVAC system and to evaluate the sensitivity of the method with respect to sensor noise variance.