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1.
丛明  任杰  秦文龙  刘冬 《机械设计与制造》2021,369(11):251-256,261
针对现有的仿下颌机器人仿生性不足,提出一种绳索驱动的仿下颌机构.首先,基于人体口颌系统冗余驱动特性、肌肉单向拉力的特性以及咀嚼肌附着点位置,进行仿下颌机构设计;该仿下颌机构采用6根绳索仿人体口颌系统的三组主要咀嚼肌(咬肌、颞肌和翼外肌),采用一对点接触高副仿人体口颌系统的颞下颌关节;然后,分析机构和推导运动学方程与雅克比矩阵;接着,为研究绳索的这种单向力特性与位形之间的关系,对该机构进行了力封闭空间分析;最后,在Adams中建立仿真模型,进行下颌功能运动(开闭运动、前后运动、侧方运动)的轨迹规划,分析绳索长度变化与人体咀嚼肌伸缩的相似性.  相似文献   
2.
为研究在常温(21±1)℃条件下不同搅拌方式对于厌氧氨氧化污泥复壮及运行影响,采用3组反应器(R1、R2、R3)搅拌方式分别为连续搅拌、间歇搅拌、间歇搅拌方式(R2、R3转速不同),对系统复壮及运行过程的脱氮性能、颗粒污泥性能等进行分析.结果表明,R1、R2、R3分别用10,2,2 d的时间氨氮、亚硝酸盐氮去除率接近100%,R2、R3的厌氧氨氧化速率更高,更适合厌氧氨氧化菌生长;周期实验结果可知,间歇搅拌方式形成的水流流化状态较弱,使反应器呈较低溶解氧的时间较长,更易抑制AOB活性,从而提高厌氧氨氧化菌活性;R1系统提供剪切力大,且持续与基质溶液接触,产生EPS多,稳定运行时期末,R1、R2、R3的颗粒污泥平均粒径为723,675,649μm.  相似文献   
3.
In this study, we investigate the immunomodulatory effects of a novel antimicrobial peptide, YD1, isolated from Kimchi, in both in vitro and in vivo models. We establish that YD1 exerts its anti-inflammatory effects via up-regulation of the Nrf2 pathway, resulting in the production of HO-1, which suppresses activation of the NF-κB pathway, including the subsequent proinflammatory cytokines IL-1β, IL-6, and TNF-α. We also found that YD1 robustly suppresses nitric oxide (NO) and prostaglandin E2 (PGE2) production by down-regulating the expression of the upstream genes, iNOS and COX-2, acting as a strong antioxidant. Collectively, YD1 exhibits vigorous anti-inflammatory and antioxidant activity, presenting it as an interesting potential therapeutic agent.  相似文献   
4.
Owing to the prohibition of cosmetic animal testing, various attempts have recently been made using skin-on-a-chip (SOC) technology as a replacement for animal testing. Previously, we reported the development of a pumpless SOC capable of drug testing with a simple drive using the principle that the medium flows along the channel by gravity when the chip is tilted using a microfluidic channel. In this study, using pumpless SOC, instead of drug testing at the single-cell level, we evaluated the efficacy of α-lipoic acid (ALA), which is known as an anti-aging substance in skin equivalents, for skin tissue and epidermal structure formation. The expression of proteins and changes in genotyping were compared and evaluated. Hematoxylin and eosin staining for histological analysis showed a difference in the activity of fibroblasts in the dermis layer with respect to the presence or absence of ALA. We observed that the epidermis layer became increasingly prominent as the culture period was extended by treatment with 10 μM ALA. The expression of epidermal structural proteins of filaggrin, involucrin, keratin 10, and collagen IV increased because of the effect of ALA. Changes in the epidermis layer were noticeable after the ALA treatment. As a result of aging, damage to the skin-barrier function and structural integrity is reduced, indicating that ALA has an anti-aging effect. We performed a gene analysis of filaggrin, involucrin, keratin 10, integrin, and collagen I genes in ALA-treated human skin equivalents, which indicated an increase in filaggrin gene expression after ALA treatment. These results indicate that pumpless SOC can be used as an in vitro skin model similar to human skin, protein and gene expression can be analyzed, and it can be used for functional drug tests of cosmetic materials in the future. This technology is expected to contribute to the development of skin disease models.  相似文献   
5.
Dong  Yibiao  Han  Ru  Wang  Danghui  Wang  Ruofei  Guo  Chenmeng 《SILICON》2021,13(9):3101-3111
Silicon - In this paper, an analytical model for negative capacitance double gate field effect transistor (NC-DG-FET) is proposed. This model includes interface traps and temperature effects, which...  相似文献   
6.
对激光选区熔化(Selective laser melting,SLM)成形马氏体时效钢进行固溶及500 ℃时效不同时间的热处理,分析时效时间对其组织性能的影响。结果表明:SLM 18Ni300钢经固溶+时效处理后,其组织为马氏体、逆转变奥氏体和Ni3(Mo, Ti)析出相,随时效时间增加,析出相数量逐渐增加并聚集长大,同时逆转变奥氏体含量增大。随时效时间的增加,其硬度和强度逐渐增加达到峰值后下降,而伸长率不断增加。SLM 18Ni300钢的最佳时效工艺为500 ℃×4 h。  相似文献   
7.
对超重力场条件下Cu熔体中的氧化夹杂进行受力分析,建立夹杂颗粒沿超重力方向上的运动速度与运动距离方程,并通过理论计算分析重力系数、夹杂物特性(尺寸、种类、含量)以及熔体温度对夹杂物在超重力场中运动行为的影响。计算结果表明,超重力场能强化Cu熔体中氧化夹杂的定向分离过程,其中重力系数、夹杂物尺寸、夹杂与熔体之间密度差(固液密度差)对夹杂颗粒运动行为影响较大。较大的重力系数、夹杂物尺寸以及固液密度差均有利于夹杂物的上浮去除。  相似文献   
8.
Chemical durability of lanthanide zirconates (A2Zr2O7) (A = La-Yb) under near-field environments is important for evaluating their application as potential nuclear waste forms. In this work, A2Zr2O7 (A = La-Yb) are synthesized by spark plasma sintering with controlled microstructure and their chemical durability are evaluated in a nitric acid solution (pH = 1). Scanning transmission electron microscopy analysis reveals an amorphous passivation film either enriched with Zr or lanthanide. The complex chemistry of the passivation films can be correlated with a transition in corrosion mechanisms from a preferential release of lanthanide in La2Zr2O7 to a preferential release of Zr in Er2Zr2O7 and Yb2Zr2O7. These results suggest a dominant mechanism of incongruent dissolution and surface reorganization for the formation of passivation films. Strong correlations are identified between the leaching rates and cation ionic size, ionic potential, electronegativity differences between A-site cation and Zr, and bonding valence sum of oxygen, suggesting important impacts of structural and bonding characteristics in controlling chemical durability of lanthanide zirconates.  相似文献   
9.
The direct-synthesis of conductive PbS quantum dot (QD) ink is facile, scalable, and low-cost, boosting the future commercialization of optoelectronics based on colloidal QDs. However, manipulating the QD matrix structures still is a challenge, which limits the corresponding QD solar cell performance. Here, for the first time a coordination-engineering strategy to finely adjust the matrix thickness around the QDs is presented, in which halogen salts are introduced into the reaction to convert the excessive insulating lead iodide into soluble iodoplumbate species. As a result, the obtained QD film exhibits shrunk insulating shells, leading to higher charge carrier transport and superior surface passivation compared to the control devices. A significantly improved power-conversion efficiency from 10.52% to 12.12% can be achieved after the matrix engineering. Therefore, the work shows high significance in promoting the practical application of directly synthesized PbS QD inks in large-area low-cost optoelectronic devices.  相似文献   
10.
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