Laser turn-on delay and chirp noise effects in Gb/sintensity-modulated direct-detection systems

This paper describes a new IM/DD optical transmission system simulation which incorporates the impact of laser diode stochastic turn-on effects on system performance. Using this simulation, experimentally observed error rate floors, due to inappropriate laser diode biasing, can be theoretically modelled and predicted, for the first time     

Caring for dying children: nurses' experiences

Interviews with 25 nurses in this grounded theory study show that when nurses recognized that a child's death was inevitable, they struggled with both grief distress and moral distress. Their distress occurred within the context of the nurse-patient relationship. Nurses employed a range of strategies to manage their distress. Several conditions facilitated or constrained nurses' strategies, and resulted in far-reaching implications both professionally and personally.     

Deformation Bands in Ceria-Stabilized Tetragonal Zirconia/Alumina : II, Stress-Induced Aging at Room Temperature

A stress-induced aging phenomenon is observed to occur at room temperature in deformation bands introduced into a 8.5 mol% ceria-stabilized tetragonal zirconia/alumina (CeTZP/A1₂O₃) composite by flexural loading. The aging occurs with time after unloading and in laboratory air. Over a period of 100 days, the concentration of monoclinic zirconia within a deformation band increases and, in addition, the wedge-shaped deformation band grows with time. Accompanying these two changes are an increase in the tensile stress in the remaining tetragonal zirconia within the deformation band and a consequential increase in the overall compressive stress within the band. The average value of the monoclinic concentration within the deformation band is found to increase parabolically with time, suggesting the mechanism responsible for the observed aging is diffusion limited. Away from the deformation bands, no aging is observed to occur, suggesting aging is stress dependent. Although a water-vapor-mediated mechanism cannot be ruled out, it is proposed that the observed aging is in fact due to a tensile stress assisted chemical reduction of Ce⁴⁺ to Ce³⁺ whose rate is controlled by the indiffusion of oxygen vacancies driven by the tensile stress gradient. It is further proposed that the deformation band grows with time, since the region ahead of the band is under tension and hence subject to an enhanced rate of reduction     

Role of ERAB/L-3-hydroxyacyl-coenzyme A dehydrogenase type II activity in Abeta-induced cytotoxicity

Endoplasmic reticulum-associated amyloid beta-peptide (Abeta)-binding protein (ERAB)/L-3-hydroxyacyl-CoA dehydrogenase type II (HADH II) is expressed at high levels in Alzheimer's disease (AD)-affected brain, binds Abeta, and contributes to Abeta-induced cytotoxicity. Purified recombinant ERAB/HADH II catalyzed the NADH-dependent reduction of S-acetoacetyl-CoA with a Km of approximately 68 microM and a Vmax of approximately 430 micromol/min/mg. The contribution of ERAB/HADH II enzymatic activity to Abeta-mediated cellular dysfunction was studied by site-directed mutagenesis in the catalytic domain (Y168G/K172G). Although COS cells cotransfected to overexpress wild-type ERAB/HADH II and variant beta-amyloid precursor protein (betaAPP(V717G)) showed DNA fragmentation, cotransfection with Y168G/K172G-altered ERAB and betaAPP(V717G) was without effect. We thus asked whether the enzyme might recognize alcohol substrates of which the aldehyde products could be cytotoxic; ERAB/HADH II catalyzed oxidation of a variety of simple alcohols (C2-C10) to their respective aldehydes in the presence of NAD+ and NAD-dependent oxidation of 17beta-estradiol. Addition of micromolar levels of synthetic Abeta(1-40) to purified ERAB/HADH II inhibited, in parallel, reduction of S-acetoacetyl-CoA (Ki approximately 1.6 microM), as well as oxidation of 17beta-estradiol (Ki approximately 3.2 microM) and (-)-2-octanol (Ki approximately 2.6 microM). Because micromolar levels of Abeta were required to inhibit ERAB/HADH II activity, whereas Abeta binding to ERAB/HADH II occurred at much lower concentrations (Km approximately 40-70 nM), the latter more closely simulating Abeta levels within cells, Abeta perturbation of ERAB/HADH II was likely to result from mechanisms other than the direct modulation of enzymatic activity. Cells cotransfected to overexpress ERAB/HADH II and betaAPP(V717G) generated malondialdehyde-protein and 4-hydroxynonenal-protein epitopes, which were detectable only at the lowest levels in cells overexpressing either ERAB/HADH II or betaAPP(V717G) alone. Generation of such toxic aldehydes was not observed in cells contransfected to overexpress Y168G/K172G-altered ERAB and betaAPP(V717G). We conclude that the generalized alcohol dehydrogenase activity of ERAB/HADH II is central to the cytotoxicity observed in an Abeta-rich environment.     

Prediction of the space-frequency correlation function for basestation diversity reception

A model is proposed to estimate the signal statistics for urban-area base stations with highly elevated antennas. Based on the model, the envelope correlation of the received signal is estimated in the case of hybrid space-frequency diversity reception at the base. It is shown that the spatial correlation or the complex signals is determined of the mean angle of arrival and the width of the incoming beam. Useful closed-form approximations for inline and broadside antenna orientations are obtained. Comparisons between the theoretical model and available experimental data provide adequate justification for the model. It is shown that the lowest spatial correlations among all the possible angular orientations an obtained when the mean direction of the incoming signals is perpendicular to the axis of the base antennas. For this case, an antenna separation of 26λ is required to achieve an envelope correlation of 0.7 when the width of the incoming beam is 0.7°, and this separation reduces to 9λ for a width of 3°. The results indicate that the required spacings can be further reduced by using frequency diversity in conjunction with space diversity. Generalization of the model to incorporate local scattering effects is also proposed     

The broadband call control demonstrator — a platform for ITU-T, DAVIC and TINA-C implementations

The paper firstly provides an introduction to the broadband call control demonstrator platform developed at BT Laboratories. It describes the basic connection level functionality used to give point-to-point and point-to-multipoint call demonstrations. It then describes the introduction of a Digital Audio-Visual Council (DAVIC)-conformant session control capability and how this is used as the basis of a more comprehensive demonstration. The paper also examines how future networking concepts such as object orientation and distributed processing environments are being introduced, in particular the interworking between DAVIC and Telecommunications Information Network Architecture Consortium (TINA-C) approaches. Finally, some of the evolutionary aspects of the broadband call control demonstrator platform are introduced.     

Adaptive Neural Network for Nuclear Medicine Image Restoration

A novel adaptive neural network is proposed for image restoration using a nuclear medicine gamma camera based on the point spread function of measured system. The objective is to restore image degradation due to photon scattering and collimator photon penetration with the gamma camera and allow improved quantitative external measurements of radionuclides in-vivo. The specific clinical model proposed is the imaging of bremsstrahlung radiation using ³²P and ⁹⁰Y because of the enhanced image degradation effects of photon scattering, photon penetration and poor signal/noise ratio in measurements of this type with the gamma camera. This algorithm model avoids the common inverse problem associated with other image restoration filters such as the Wiener filter. The relative performance of the adaptive NN for image restoration is compared to a previously reported order statistic neural network hybrid (OSNNH) filter by these investigators, a traditional Weiner filter and a modified Hopfield neural network using simulated degraded images with different noise levels. Quantitative metrics such as the change of signal to noise ratio (SNR) are used to compare filter performance. The adaptive NN yields comparable results for image restoration with a slightly better performance for the images with higher noise level as often encountered in bremsstrahlung detection with the gamma camera. Experimental attenuation measurements were also performed in a water tank using two radionuclides, ³²P and ⁹⁰Y, typically used for antibody therapy. Similar values for an effective attenuation coefficient was observed for the restored images using the OSNNH filters and adaptive NN which demonstrate that the restoration filters preserves the total counts in the image as required for quantitative in-vivo measurements. The adaptive NN was computationally more efficient by a factor 4–6 compared to the OSNNH filter. The filter architecture, in turn, is also optimum for parallel processing or VLSI implementation as required for planar and particularly for tomographic mode of detection using the gamma camera. The proposed adaptive NN method should also prove to be useful for quantitative imaging of single photon emitters for other nuclear medicine tomographic imaging applications using positron emitters and direct X-ray photon detection.     

Millimeter wave imaging lens antenna

The factors which influence the design of lenses suitable for imaging at millimetre wavelengths are discussed. Examples are given of optical designs for a military tracking application, firstly for use with an open ended waveguide array, and secondly for use with monolithic arrays, each covering a field of view of ±20°.     

CONTINUOUS FERMENTATION OF GLUCOSE SOLUTIONS

Use of a continuous-flow plug fermentor to ferment glucose solutions was found to be possible only with unrefined commercial glucose and not with pure glucose. Even when the former was used problems were encountered due to a gradual increase in back pressure across the yeast bed. With the commencement of glucose metabolism in the yeast bed, ‘shock’ excretion of potassium and magnesium ions as well as of low molecular weight nitrogenous material was observed. The product from the fermentor contained an abnormally high level of α-diketones viz., 1–3 mg/litre.     

Probabilistic Discovery of Semantically Diverse Content in MANETs

Mobile ad hoc networks rely on the opportunistic interaction of autonomous nodes to form networks without the use of infrastructure. Given the radically decentralized nature of such networks, their potential for autonomous communication is significantly improved when the need for a priori consensus among the nodes is kept to a minimum. This paper addresses an issue within the domain of semantic content discovery, namely, its current reliance on the preexisting agreement between the schema of content providers and consumers. We present OntoMobil, a semantic discovery model for ad hoc networks that removes the assumption of a globally known schema and allows nodes to publish information autonomously. The model relies on the randomized dissemination and replication of metadata through a gossip protocol. Given schemas with partial similarities, the randomized metadata dissemination mechanism facilitates eventual semantic agreement and provides a substrate for the scalable discovery of content. A discovery protocol can then utilize the replicated metadata to identify content within a predictable number of hops using semantic queries. A stochastic analysis of the gossip protocol presents the different trade-offs between discoverability and replication. We evaluate the proposed model by comparing OntoMobil against a broadcast-based protocol and demonstrate that semantic discovery with proactive replication provides good scalability properties, resulting in a high discovery ratio with less overhead than a reactive nonreplicated discovery approach.