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排序方式: 共有258条查询结果,搜索用时 78 毫秒
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Marine Milard Fabienne Laugerette Annie Durand Charline Buisson Emmanuelle Meugnier Emmanuelle Loizon Corinne Louche‐Pelissier Valrie Sauvinet Lorna Garnier Sbastien Viel Karne Bertrand Florent Joffre David Cheillan Lydie Humbert Dominique Rainteau Pascale Plaisanci Laure B. Bindels Audrey M. Neyrinck Nathalie M. Delzenne Marie‐Caroline Michalski 《Molecular nutrition & food research》2019,63(4)
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Dr. Laura Fourmois Dr. Florent Poyer Dr. Aude Sourdon Delphine Naud-Martin Dr. Sounderya Nagarajan Dr. Rahima Chennoufi Dr. Eric Deprez Dr. Marie-Paule Teulade-Fichou Dr. Florence Mahuteau-Betzer 《Chembiochem : a European journal of chemical biology》2021,22(14):2457-2467
Mitochondria are involved in many cellular pathways and dysfunctional mitochondria are linked to various diseases. Hence efforts have been made to design mitochondria-targeted fluorophores for monitoring the mitochondrial status. However, the factors that govern the mitochondria-targeted potential of dyes are not well-understood. In this context, we synthesized analogues of the TP-2Bzim probe belonging to the vinyltriphenylamine (TPA) class and already described for its capacity to bind nuclear DNA in fixed cells and mitochondria in live cells. These analogues ( TP-1Bzim, TPn-2Bzim, TP1+-2Bzim, TN-2Bzim ) differ in the cationic charge, the number of vinylbenzimidazolium branches and the nature of the triaryl core. Using microscopy, we demonstrated that the cationic derivatives accumulate in mitochondria but do not reach mtDNA. Under depolarisation of the mitochondrial membrane, TP-2Bzim and TP1+-2Bzim translocate to the nucleus in direct correlation with their strong DNA affinity. This reversible phenomenon emphasizes that these probes can be used to monitor ΔΨm variations. 相似文献
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Vertically aligned carbon nanotube‐based composite: Elaboration and monitoring of the nanotubes alignment 下载免费PDF全文
Mickael Huard Florent Roussel Stéphan Rouzière Stéphanie Patel Mathieu Pinault Martine Mayne‐L'Hermite Pascale Launois 《应用聚合物科学杂志》2014,131(1)
We present the different elaboration steps of a composite formed of carbon nanotubes (CNT) carpet embedded in an epoxy polymer. Detailed characterization at each step of the elaboration process is performed. The good alignment of CNT in as‐grown carpets is kept all along the elaboration process of the composite, as it is measured at both macro and microscopic scales by X‐ray scattering. We also ensured by X‐ray fluorescence measurements that the iron‐based catalyst particles used for the synthesis were removed from the carpet after a high temperature post‐annealing treatment. These measurements give valuable information for further applications involving unidirectional nanotube composites and membranes, where CNT alignment is a key parameter. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131, 39730. 相似文献
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Valentin Magn Florent Blanchard Angela Marinetti Arnaud Voituriez Xavier Guinchard 《Advanced Synthesis \u0026amp; Catalysis》2016,358(21):3355-3361
N‐Propargyl‐ and N‐homoallenyl‐2‐bromo‐β‐tryptamines undergo gold(I)‐catalyzed dearomatizing cyclizations to afford 2‐bromospiroindolenines that are in situ hydrolyzed to furnish spirooxindoles in a one‐pot process. Tryptophane derivatives (R2=CO2Et) led upon cyclization to chiral spirooxindoles in excellent diastereoselectivities.
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Quick U-building (QUB) is a method for short time measurement of energy performance of buildings, typically one night. It uses the indoor air temperature response to the power delivered to the indoor air by electric heaters. This paper introduces a method for estimating the expected measurement error as a function of the amplitude and the time duration of the input signal based on the decomposition of the time response of a state-space model into a sum of exponentials by using the eigenvalues of the state matrix. It is shown that the buildings have a group of dominant time constants, which gives an exponential response, and many very short and very large time constants, which have a small influence on the response. The analysis of the eigenvalues demonstrates that the QUB experiment may be done in a rather short time as compared with the largest time constant of the building. 相似文献
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Reactive extraction of bio‐based 3‐hydroxypropionic acid assisted by hollow‐fiber membrane contactor using TOA and Aliquat 336 in n‐decanol 下载免费PDF全文
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Alessandro Sannino Dr. Elena Gabriele Martina Bigatti Dr. Sara Mulatto Dr. Jacopo Piazzi Dr. Jörg Scheuermann Prof. Dr. Dario Neri Dr. Etienne J. Donckele Dr. Florent Samain 《Chembiochem : a European journal of chemical biology》2019,20(7):955-962
DNA-encoded chemical libraries are often used for the discovery of ligands against protein targets of interest. These large collections of DNA-barcoded chemical compounds are typically screened by using affinity capture methodologies followed by PCR amplification and DNA sequencing procedures. However, the performance of individual steps in the selection procedures has been scarcely investigated, so far. Herein, the quantitative analysis of selection experiments, by using three ligands with different affinity to carbonic anhydrase IX as model compounds, is described. In the first set of experiments, quantitative PCR (qPCR) procedures are used to evaluate the recovery and selectivity for affinity capture procedures performed on different solid-phase supports, which are commonly used for library screening. In the second step, both qPCR and analysis of DNA sequencing results are used to assess the recovery and selectivity of individual carbonic anhydrase IX ligands in a library, containing 360 000 compounds. Collectively, this study reveals that selection procedures can be efficient for ligands with sub-micromolar dissociation constants to the target protein of interest, but also that selection performance dramatically drops if 104 copies per library member are used as the input. 相似文献
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Mass customization (MC) has become a reality and cannot be neglected as one of the leading strategies in satisfying customers and assuring companies survival in today's markets. MC can be offered either via product variability or process variability. How this is achieved using both approaches is the main core of this article. After an overview of related works, the influence of design variability on the overall generated value of the product is studied via a metric approach. A case study of the shoe industry is also presented, based on the experience of a European project called Dorothy. 相似文献