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排序方式: 共有74条查询结果,搜索用时 15 毫秒
1.
Mariamichela Lanzilli Nunzia Esercizio Marco Vastano Zhaohui Xu Genoveffa Nuzzo Carmela Gallo Emiliano Manzo Angelo Fontana Giuliana dIppolito 《International journal of molecular sciences》2021,22(1)
The phylum Thermotogae is composed of a single class (Thermotogae), 4 orders (Thermotogales, Kosmotogales, Petrotogales, Mesoaciditogales), 5 families (Thermatogaceae, Fervidobacteriaceae, Kosmotogaceae, Petrotogaceae, Mesoaciditogaceae), and 13 genera. They have been isolated from extremely hot environments whose characteristics are reflected in the metabolic and phenotypic properties of the Thermotogae species. The metabolic versatility of Thermotogae members leads to a pool of high value-added products with application potentials in many industry fields. The low risk of contamination associated with their extreme culture conditions has made most species of the phylum attractive candidates in biotechnological processes. Almost all members of the phylum, especially those in the order Thermotogales, can produce bio-hydrogen from a variety of simple and complex sugars with yields close to the theoretical Thauer limit of 4 mol H2/mol consumed glucose. Acetate, lactate, and L-alanine are the major organic end products. Thermotagae fermentation processes are influenced by various factors, such as hydrogen partial pressure, agitation, gas sparging, culture/headspace ratio, inoculum, pH, temperature, nitrogen sources, sulfur sources, inorganic compounds, metal ions, etc. Optimization of these parameters will help to fully unleash the biotechnological potentials of Thermotogae and promote their applications in industry. This article gives an overview of how these operational parameters could impact Thermotogae fermentation in terms of sugar consumption, hydrogen yields, and organic acids production. 相似文献
2.
Alessandra Di Paola Giuseppe Palumbo Pietro Merli Maura Argenziano Chiara Tortora Luisa Strocchio Domenico Roberti Claudia Santoro Silverio Perrotta Francesca Rossi 《International journal of molecular sciences》2021,22(1)
Immune Thrombocytopenia (ITP) is an autoimmune disease characterized by autoantibodies-mediated platelet destruction, a prevalence of M1 pro-inflammatory macrophage phenotype and an elevated T helper 1 and T helper 2 lymphocytes (Th1/Th2) ratio, resulting in impairment of inflammatory profile and immune response. Macrophages are immune cells, present as pro-inflammatory classically activated macrophages (M1) or as anti-inflammatory alternatively activated macrophages (M2). They have a key role in ITP, acting both as effector cells, phagocytizing platelets, and, as antigen presenting cells, stimulating auto-antibodies against platelets production. Eltrombopag (ELT) is a thrombopoietin receptor agonist licensed for chronic ITP to stimulate platelet production. Moreover, it improves T and B regulatory cells functions, suppresses T-cells activity, and inhibits monocytes activation. We analyzed the effect of ELT on macrophage phenotype polarization, proposing a new possible mechanism of action. We suggest it as a mediator of macrophage phenotype switch from the M1 pro-inflammatory type to the M2 anti-inflammatory one in paediatric patients with ITP, in order to reduce inflammatory state and restore the immune system function. Our results provide new insights into the therapy and the management of ITP, suggesting ELT also as immune-modulating drug. 相似文献
3.
The paper contains the first complete proof of strong normalization (SN) for full second order linear logic (LL): Girard’s original proof uses a standardization theorem which is not proven. We introduce sliced pure structures (sps), a very general version of Girard’s proof-nets, and we apply to sps Gandy’s method to infer SN from weak normalization (WN). We prove a standardization theorem for sps: if WN without erasing steps holds for an sps, then it enjoys SN. A key step in our proof of standardization is a confluence theorem for sps obtained by using only a very weak form of correctness, namely acyclicity slice by slice. We conclude by showing how standardization for sps allows to prove SN of LL, using as usual Girard’s reducibility candidates. 相似文献
4.
Video games and new communication metaphors are quickly changing today’s young people habits. Considering the actual e-learning scenarios, embedded in a fully technological enabled environment it is crucial to take advantage of this kind of capabilities to let learning process gain best results. 相似文献
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Fault-accommodation with intelligent sensors 总被引:1,自引:0,他引:1
Giacomo Tortora Author Vitae Author Vitae David Clarke Author Vitae 《Automatica》2003,39(7):1227-1233
Optimal sensor fault-accommodation is considered for faults modelled by an increase in measurement noise. This noise is taken to be bounded and its probabilistic properties unknown. It is assumed that intelligent (e.g. self-validating) instrumentation is in use and estimates of the noise bounds are available. The fault-tolerant controller is designed to optimize a noise rejection and a nominal reference tracking index and leads to a mixed norm minimization problem (l1/l2). We exploit known results and a particular feedback configuration to show that it is possible to optimize simultaneously without a trade-off the two performance indices. The results are applied to systems where the presence of auxiliary measurements allows for an optimal fault-accommodation strategy. Using properties of the optimal solution, we define a factorization for the optimal controller alternative to the Youla parametrization, leading to an algorithm which is optimal, transparent and efficient. 相似文献
8.
Virtual images for similarity retrieval in image databases 总被引:1,自引:0,他引:1
Petraglia G. Sebillo M. Tucci M. Tortora G. 《Knowledge and Data Engineering, IEEE Transactions on》2001,13(6):951-967
We introduce the virtual image, an iconic index suited for pictorial information access in a pictorial database, and a similarity retrieval approach based on virtual images to perform content-based retrieval. A virtual image represents the spatial information contained in a real image in explicit form by means of a set of spatial relations. This is useful to efficiently compute the similarity between a query and an image in the database. We also show that virtual images support real-world applications that require translation, reflection, and/or rotation invariance of image representation 相似文献
9.
Margaret Ottaviano Emilio Francesco Giunta Marianna Tortora Marcello Curvietto Laura Attademo Davide Bosso Cinzia Cardalesi Mario Rosanova Pietro De Placido Erica Pietroluongo Vittorio Riccio Brigitta Mucci Sara Parola Maria Grazia Vitale Giovannella Palmieri Bruno Daniele Ester Simeone 《International journal of molecular sciences》2021,22(7)
As widely acknowledged, 40–50% of all melanoma patients harbour an activating BRAF mutation (mostly BRAF V600E). The identification of the RAS–RAF–MEK–ERK (MAP kinase) signalling pathway and its targeting has represented a valuable milestone for the advanced and, more recently, for the completely resected stage III and IV melanoma therapy management. However, despite progress in BRAF-mutant melanoma treatment, the two different approaches approved so far for metastatic disease, immunotherapy and BRAF+MEK inhibitors, allow a 5-year survival of no more than 60%, and most patients relapse during treatment due to acquired mechanisms of resistance. Deep insight into BRAF gene biology is fundamental to describe the acquired resistance mechanisms (primary and secondary) and to understand the molecular pathways that are now being investigated in preclinical and clinical studies with the aim of improving outcomes in BRAF-mutant patients. 相似文献
10.
Vapor barrier properties of polycaprolactone montmorillonite nanocomposites: effect of clay dispersion 总被引:3,自引:0,他引:3
Giuliana GorrasiMariarosaria Tortora Vittoria Vittoria Eric PolletBénédicte Lepoittevin Michael AlexandrePhilippe Dubois 《Polymer》2003,44(8):2271-2279
Different compositions of poly(ε-caprolactone) (PCL) and (organo-modified) montmorillonite were prepared by melt blending or catalyzed ring opening polymerization of ε-caprolactone. Microphase composites were obtained by direct melt blending of PCL and sodium montmorillonite (MMT-Na+). Exfoliated nanocomposites were obtained by in situ ring opening polymerization of ε-caprolactone with an organo-modified montmorillonite (MMT-(OH)2) by using dibutyltin dimethoxide as an initiator/catalyst. Intercalated nanocomposites were formed either by melt blending with organo-modified montmorillonite or in situ polymerization within sodium montmorillonite. The barrier properties were studied for water vapor and dichloromethane as an organic solvent. The sorption (S) and the zero concentration diffusion coefficient (D0) were evaluated for both vapors. The water sorption increases with increasing the MMT content, particularly for the microcomposites containing the unmodified MMT-Na+. The thermodynamic diffusion parameters, D0, were compared to the value of the parent PCL: both microcomposites and intercalated nanocomposites show diffusion parameters very near to PCL. At variance exfoliated nanocomposites show much lower values, even for small montmorillonite content. In the case of the organic vapor, the value of sorption at low relative pressure is mainly dominated by the amorphous fraction present in the samples, not showing any preferential adsorption on the inorganic component. At high relative pressure the isotherms showed an exponential increase of sorption, due to plasticization of the polyester matrix. The D0 parameters were also compared to those of the unfilled PCL; in this case, both the exfoliated and the intercalated samples showed lower values, due to a more tortuous path for the penetrant molecules. 相似文献