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排序方式: 共有555条查询结果,搜索用时 218 毫秒
1.
Effects of time and point-of-use devices on arsenic levels in Southeastern Michigan drinking water, USA 总被引:1,自引:0,他引:1
Health effects associated with chronic, low-level exposures to arsenic in drinking water (<100 microg/L) remain unclear, in part due to uncertainties in assessing exposure. Drinking water concentrations have been used to assess past exposure to arsenic in epidemiological studies, under the assumption that a single measurement can be used to estimate historical exposure. This study aims to better understand (1) temporal variability in arsenic concentrations in drinking water and (2) the impact of point-of-use (POU) treatment devices on arsenic exposure measurements, and on reliability of the exposure measurement for population-level studies. Multiple drinking water samples were collected at two points in time (an average of fourteen months apart) for 261 individuals enrolled in a case-control study of arsenic exposure and bladder cancer in Michigan. Sources of drinking water included private wells (n = 221), public water supplies (n = 33), and bottled water (n = 7); mean arsenic concentration was highest in private wells (7.28 microg/L) and lowest in bottled water samples (0.28 microg/L). Arsenic concentrations in primary drinking water samples were highly correlated (r = 0.88, p < 0.0001, n = 196), with 3% of the water sources exceeding the United States Environmental Protection Agency's Maximum Contaminant Level (MCL) in one sample but not in the other sample. Measurement reproducibility did not vary by type of POU device (e.g., softener, filter, reverse osmosis system). Arsenic concentrations did differ, however, between samples treated with POU devices and untreated samples taken on the same day. Substantial differences in arsenic concentrations were consistently observed for reverse osmosis systems; other POU devices had variable effects on arsenic concentrations. These results indicate that while a single residential arsenic measurement may be used to represent exposure in this region, researchers must obtain information on changes in water source and POU treatment devices to better characterize population exposures over time. 相似文献
2.
Christopher J. Norris Gregory J. Meadway Michael J. O'Sullivan Ian P. Bond Richard S. Trask 《Advanced functional materials》2011,21(19):3624-3633
This paper demonstrates the first steps towards self‐healing composites that exploit a design philosophy inspired by the damage tolerance and self‐repair functions of bone. Cracking in either fibre reinforced polymers (FRP) or bone, if left unattended, can grow under subsequent cyclic stresses eventually leading to catastrophic failure of the structure. On detection of cracks, an FRP component must be repaired or completely replaced, whereas bone utilises a series of complex processes to repair such damage. Under normal circumstances, these processes allow the skeleton to continually perform over the lifespan of the organism, a highly desirable aspiration for engineering materials. A simple vasculature design incorporated into a FRP via a “lost wax” process was found to facilitate a self‐healing function which resulted in an outstanding recovery (≥96%) in post‐impact compression strength. The process involved infusion of a healing resin through the vascule channels. Resin egress from the backface damage, ultrasonic C‐scan testing, and microscopic evaluation all provide evidence that sufficient vascule–damage connectivity exists to confer a reliable and efficient self‐healing function. 相似文献
3.
Derek Stewart Pamela M. Norris 《Nanoscale and Microscale Thermophysical Engineering》2013,17(2):89-101
This study examines the influence of radial thickness on the thermal conductivity of thin metallic wires. While size effects on the electrical conductivity of thin wires have been discussed in the literature, research into size effects on thermal conductivity still requires investigation. At such small length scales, the assumption that the reduced electrical conductivity can be simply related to the reduced thermal conductivity through a Wiedemann-Franz relation is subject to question. This study uses the Boltzmann transport equation for electrons to determine the thermal conductivity of a thin wire directly. Electrons are treated as the primary heat carriers in a thin wire with a thermal gradient along the axis. A single-crystal, defect-free, metallic thin wire is considered in the derivation. An expression is presented which accounts for the radial size effects on axial thermal conductivity. The derived thermal conductivity is compared to expressions for the reduced electrical conductivity, and the applicability of the Wiedemann-Franz relation is discussed. 相似文献
4.
Pratt Michael W.; Norris Joan E.; Arnold Mary Louise; Filyer Rebecca 《Canadian Metallurgical Quarterly》1999,14(3):414
Little research so far has examined storytelling as a channel of value socialization. In the present study, 129 adults from 3 age groups (18–26, 28–50, 60–75) were asked to tell stories for adolescents about 2 of their past value-learning experiences. Generative concern (D. P. McAdams & E. de St. Aubin, 1992) and moral reasoning stage level were also assessed. Stronger generative concern was predictive of a greater sense of having learned important lessons from these past events, of stronger adult value socialization investment, and of more engaging narratives for adolescents as judged by a panel of uninstructed raters. Higher levels of moral reasoning were positively related to generative concern and to a stronger sense of past lessons learned. Generativity appears important to the project of value socialization across the adult life span. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
5.
6.
Gangliosides are a large family of glycosphingolipids that are abundant in the brain, and have been shown to affect neuronal
plasticity during development, adulthood, and aging. We developed a fast, efficient, and sensitive liquid chromatography–mass
spectrometry method to quantify eight different classes of gangliosides (GM1, GM2, GM3, GD3, GD1a, GD1b, GT1b, GQ1b) in the brains of 2-day-old and 80-day-old Wistar rats. The gangliosides were extracted from rat brain using a modified Svennerholm
and Fredman method. After ganglioside class separation using a hydrophilic high performance liquid chromatography (HPLC) column,
the resolving power of the LTQ-Orbitrap™ mass spectrometer was used to extract and sum the major species of each ganglioside
class, generating fully resolved extracted ion current peaks for both standards and samples. The flexibility and the specificity
of this method are such that it can be applied to the analysis of other ganglioside species/classes not discussed in this
paper, provided appropriate standards are available. The method had good repeatability (coefficient of variation 4.8–12.3%)
and mean recoveries in the range 92–107%. 相似文献
7.
Kate J. Norris Andrew J. Lohn Takehiro Onishi Elane Coleman Vernon Wong Ali Shakouri Gary S. Tompa Nobuhiko P. Kobayashi 《Journal of Electronic Materials》2012,41(5):971-976
We report the growth of erbium monoantimonide (ErSb) thin films on indium antimonide (100) substrates by low-pressure metalorganic
chemical vapor deposition. The growth rate of ErSb thin films shows strong dependency on the growth temperature and the Sb/Er
precursor molar flow rate ratio. Scanning electron microscopy, energy-dispersive x-ray spectroscopy, and x-ray diffractometry
(XRD) were employed to study the ErSb thin films grown under the growth conditions that gave the maximum growth rate in the
range we investigated. We also report the growth of two types of nanocomposites in which ErSb nanocolumns or nanoslabs with
lengths ~500 nm and diameters 20 nm to 30 nm are embedded in Zn-doped InGaSb (ErSb/InGaSb:Zn) and ErSb nanoparticles with
diameters of ~30 nm are embedded in Zn-doped InSbAs (ErSb/InSbAs:Zn). These nanocomposites were intended to increase phonon
scattering in a mid-to-long phonon wavelength range to reduce lattice thermal conductivity. We used time-domain thermoreflectance
to measure total thermal conductivity for the two types of nanocomposites, obtaining 4.0 ± 0.6 W/mK and 6.7 ± 0.8 W/mK for
the ErSb/InAsSb:Zn and ErSb/InGaSb:Zn nanocomposites, respectively, which suggests that the thermal conductivity was close
to or slightly smaller than the alloy limit of the two ternary alloy hosts. The two nanocomposites were further studied by
transmission electron microscopy (TEM) to reveal their microscopic features and by XRD to assess their crystalline structures. 相似文献
8.
S. T. Jespersen F. Baudry M. D. Wakeman V. Michaud P. Blanchard R. Norris J-A. E. Månson 《Applied Composite Materials》2009,16(6):331-344
A novel thermoplastic programmable preforming process, TP-P4, has been used to manufacture preforms for non-isothermal compression
molding. Commingled glass and polypropylene yarns are deposited by robot onto a vacuum screen, followed by a heat-setting
operation to stabilize the as-placed yarns for subsequent handling. After an optional additional preconsolidation stage, the
preforms are molded by preheating and subsequent press forming in a shear edge tool. The in- and out-of-plane flow capabilities
of the material were investigated, and compared to those of 40 wt% Glass Mat Thermoplastics (GMTs). Although the TP-P4 material has a fiber fraction of 60 wt%, the material could be processed to fill 77 mm deep ribs with a thickness of 3 mm, indicative of complex part production.
The pressure requirements for out-of-plane flow were shown to depend on the fiber length and fiber alignment. Segregation
phenomena were found to be less severe with TP-P4 than with GMT material. 相似文献
9.
Corrugator supercilii muscle activity is considered an objective measure of valence because it increases in response to negatively valenced facial expressions (angry) and decreases to positive expressions (happy). The authors sought to determine if corrugator activity could be used as an objective measure of positivity-negativity bias. The authors recorded corrugator responses as participants rated angry, happy, and surprised faces as “positive” or “negative.” The critical measure of bias was the percentage of positive versus negative ratings assigned to surprised faces by each participant. Reaction times for surprise expressions were longer than for happy and angry expressions, consistent with their ambiguous valence. Participants who tended to rate surprised faces as negative showed increased corrugator activity to surprised faces, whereas those who tended to rate surprise as positive showed decreased activity. Critically, corrugator responses reflected the participants’ bias (i.e., their tendency to rate surprise as positive or negative). These data show that surprised faces constitute a useful tool for assessing individual differences in positivity-negativity bias, and that corrugator activity can objectively reflect this bias. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
10.
K. DiGiacomo E. Norris F.R. Dunshea B.J. Hayes L.C. Marett W.J. Wales B.J. Leury 《Journal of dairy science》2018,101(7):6474-6485
Residual feed intake (RFI) is defined as the difference between the actual and expected feed intake required to support animal maintenance and growth. Thus, a cow with a low RFI can obtain nutrients for maintenance and growth from a reduced amount of feed compared with a cow with a high RFI. Variation in RFI is underpinned by a combination of factors, including genetics, metabolism, thermoregulation and body composition; hypothalamic-pituitary-adrenal (HPA) axis responsiveness is also a possible contributor. Responses to 3 metabolic challenges were measured in lactating and nonlactating dairy cattle. Sixteen Holstein Friesian cows with phenotypic RFI measurements that were obtained during the growth period (188–220 d old) were grouped as either low-calfhood RFI (n = 8) or high-calfhood RFI (n = 8). An ACTH (2 µg/kg of body weight), insulin (0.12 U/kg), and epinephrine (a low dose of 0.1 µg/kg and a high dose of 1.6 µg/kg of epinephrine) challenge were each conducted during both midlactation (122 ± 23.4 d in milk) and the nonlactating period (dry period; approximately 38 d after cessation of milking). Cows were housed in metabolism stalls for the challenges and were fed a diet of alfalfa cubes ad libitum for at least 10 d before the experiment (lactating cows also were offered a total of 6 kg of dry matter/d of crushed wheat grain plus minerals fed as 3 kg of dry matter at each milking) and were fasted for 12 h before the challenges. The efficiency of conversion of feed into milk (the ratio of feed consumed to milk produced over the 7 d before the experiment) during midlactation was better (lower) in low-calfhood RFI cows, although dry matter intake did not differ between RFI groups. Low-calfhood RFI cows exhibited a lower plasma cortisol response to the ACTH challenge than high-calfhood RFI cows, particularly in midlactation (?15%). The low-calfhood RFI cows had a greater plasma insulin-like growth factor-1 response to the insulin challenge and plasma fatty acid response to epinephrine compared with the high-calfhood RFI cows. These data suggest that high-calfhood RFI cows exhibit a more responsive HPA axis. As divergence in RFI measured during growth is retained (although reduced) during lactation, it is possible that energy is used to respond to HPA axis activation at the expense of production in high-calfhood RFI dairy cattle during lactation and contributes to a decrease in overall feed use efficiency. 相似文献