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排序方式: 共有1300条查询结果,搜索用时 15 毫秒
1.
Suk-Young Song Soonil Pyo Sungchul Choi Hee Sang Oh Jung Hwa Seo Ji Hea Yu Ahreum Baek Yoon-Kyum Shin Hoo Young Lee Ja Young Choi Sung-Rae Cho 《International journal of molecular sciences》2021,22(7)
Hypoxic–ischemic encephalopathy (HIE) is a devastating neonatal brain condition caused by lack of oxygen and limited blood flow. Environmental enrichment (EE) is a classic paradigm with a complex stimulation of physical, cognitive, and social components. EE can exert neuroplasticity and neuroprotective effects in immature brains. However, the exact mechanism of EE on the chronic condition of HIE remains unclear. HIE was induced by a permanent ligation of the right carotid artery, followed by an 8% O2 hypoxic condition for 1 h. At 6 weeks of age, HIE mice were randomly assigned to either standard cages or EE cages. In the behavioral assessments, EE mice showed significantly improved motor performances in rotarod tests, ladder walking tests, and hanging wire tests, compared with HIE control mice. EE mice also significantly enhanced cognitive performances in Y-maze tests. Particularly, EE mice showed a significant increase in Cav 2.1 (P/Q type) and presynaptic proteins by molecular assessments, and a significant increase of Cav 2.1 in histological assessments of the cerebral cortex and hippocampus. These results indicate that EE can upregulate the expression of the Cav 2.1 channel and presynaptic proteins related to the synaptic vesicle cycle and neurotransmitter release, which may be responsible for motor and cognitive improvements in HIE. 相似文献
2.
Youri Oh Hoyong Jung Hyejin Kim Jihyun Baek Joonhong Jun Hyunwook Cho Daseul Im Jung-Mi Hah 《International journal of molecular sciences》2021,22(8)
Polo-like kinase 1 (PLK1) plays an important role in cell cycle progression and proliferation in cancer cells. PLK1 also contributes to anticancer drug resistance and is a valuable target in anticancer therapeutics. To identify additional effective PLK1 inhibitors, we performed QSAR studies of two series of known PLK1 inhibitors and proposed a new structure based on a hybridized 3D-QSAR model. Given the hybridized 3D-QSAR models, we designed and synthesized 4-benzyloxy-1-(2-arylaminopyridin-4-yl)-1H-pyrazole-3-carboxamides, and we inspected its inhibitory activities to identify novel PLK1 inhibitors with decent potency and selectivity. 相似文献
3.
Seong-Joong Kim Yeojin Ahn Jeong F. Kim Seung-Eun Nam Hosik Park Young Hoon Cho Kyung-youl Baek You-In Park 《应用聚合物科学杂志》2021,138(7):49860
To overcome the plasticization effect in polyimide membranes, many researchers have proposed crosslinking method. This can reduce an inter-segmental mobility by tightening and rigidifying the polymer chains. However, it is difficult to modify the whole polymer chains throughout the membrane because the reaction can be hindered by the diffusion rate of the crosslinker. In particular, it is hard for bulky crosslinker to penetrate a dense membrane with a small d-spacing. This study investigated the effect of crosslinking a dense Matrimid membrane with p-phenylenediamine (p-PDA) via two different crosslinking methods (i.e., methanol-swelling crosslinking process [M-SCP] and liquid-phase crosslinking process [L-PCP]). Most of the crosslinking reaction in M-SCP occurs on the membrane surface due to difficulty in penetration of the bulky p-PDA into the Matrimid dense membrane. In contrast, the L-PCP allows uniform crosslinking across the membrane. The membranes crosslinked using L-PCP showed excellent chemical resistance. Furthermore, the plasticization phenomenon was not observed in the membranes crosslinked using L-PCP with p-PDA more than 15%. Meanwhile, the membrane crosslinked using M-SCP exhibited poor plasticization and chemical resistance properties. These results showed that the L-PCP method can be more effective for the crosslinking of dense membrane to deliver both high plasticization and chemical resistance. 相似文献
4.
Jeong Ji-Seong Song Min-Ho Lee Sang-Ho Kim Mihye Baek Nakhoon Yoo Kwan-Hee 《The Journal of supercomputing》2019,75(8):4505-4518
The Journal of Supercomputing - This paper presents a web-based three-dimensional (3D) navigation system for a spinal disease ontology using a 3D virtual human spine. The 3D navigation system... 相似文献
5.
Baek Mi-eun Ameer Kashif Jo Yunhee Chung Namhyeok Choi Minji Kim Jung-ok Won Jaehee Lee Sang-Han Kwon Joong-Ho 《Food science and biotechnology》2020,29(5):705-715
Food Science and Biotechnology - Medicinal herbs comprise of heavy microbial contaminations. This study aimed to assess microbial hazards including foodborne pathogens in 20 commercial medicinal... 相似文献
6.
Optoelectronics: High‐Performance Planar Perovskite Optoelectronic Devices: A Morphological and Interfacial Control by Polar Solvent Treatment (Adv. Mater. 23/2015) 下载免费PDF全文
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8.
Ali Hussein F. M. Khan Abdul Manan Baek Hangyeol Shin Buhyun Kim Youngshik 《Microsystem Technologies》2021,27(6):2481-2492
Microsystem Technologies - In this research a biologically inspired finger-like mechanism similar to human musculoskeletal system is developed based on Shape Memory Alloys (SMAs). SMA actuators are... 相似文献
9.
10.
Zhiyu Sun Ethan Rooke Jerome Charton Yusen He Jia Lu Stephen Baek 《Computer Graphics Forum》2020,39(6):204-216
In this paper, we propose a novel formulation extending convolutional neural networks (CNN) to arbitrary two-dimensional manifolds using orthogonal basis functions called Zernike polynomials. In many areas, geometric features play a key role in understanding scientific trends and phenomena, where accurate numerical quantification of geometric features is critical. Recently, CNNs have demonstrated a substantial improvement in extracting and codifying geometric features. However, the progress is mostly centred around computer vision and its applications where an inherent grid-like data representation is naturally present. In contrast, many geometry processing problems deal with curved surfaces and the application of CNNs is not trivial due to the lack of canonical grid-like representation, the absence of globally consistent orientation and the incompatible local discretizations. In this paper, we show that the Zernike polynomials allow rigourous yet practical mathematical generalization of CNNs to arbitrary surfaces. We prove that the convolution of two functions can be represented as a simple dot product between Zernike coefficients and the rotation of a convolution kernel is essentially a set of 2 × 2 rotation matrices applied to the coefficients. The key contribution of this work is in such a computationally efficient but rigorous generalization of the major CNN building blocks. 相似文献