Notch effect on creep–fatigue life for Sn–3.5Ag solder

This paper studies the creep–fatigue crack initiation and failure lives of Sn–3.5Ag solder notched specimens focused on the multiaxial strain at the notch root. Push–pull creep–fatigue tests were performed using three circumferential notched specimens using four kinds of creep–fatigue strain waveforms. Multiaxial strains at the notched section were calculated by finite element (FE) analysis under four kinds of creep–fatigue loading. Creep–fatigue damage laws were applied for evaluating the crack initiation and failure lives using the multiaxial strains obtained by the FE analysis. von Mises equivalent strain at the notch root estimated the crack initiation lives with a large scatter as well as the failure lives. Instead, the mean value of von Mises equivalent strain over the cross section of the notch root estimated the crack initiation and failure lives with a small scatter.     

Effects of hydroperoxide in breads on IgE antibody responses

The effect of hydroperoxide in breads on antigen-antibody reaction against IgE was examined. We compared the antigen-antibody reaction against IgE between dough including hydroperoxide and that not including hydroperoxide. Crude proteins extracted from the dough including hydroperoxide showed weak antigen-antibody reaction on allergic tests such as ring precipitin test with human-specific IgE, and the IgE binding activity on ELISA. In contrast, the dough without hydroperoxide showed antigen-antibody reaction. The crude proteins extracted from the dough with hydroperoxide or without hydroperoxide were applied by affinity chromatography of trypsin-immobilized chitin. Then proteins having affinity were recovered. The recovered proteins were separated by SDS-PAGE. Each protein was examined for the IgE binding activity on ELISA. The IgE binding activity of baked bread was studied as well. Crude proteins of baked bread made from dough including hydroperoxide showed weaker IgE binding activity on ELISA than proteins of baked bread made from dough without hydroperoxide. Those results suggested that addition of hydroperoxide into dough affects on antigen activation.     

Kinetic resolution of an indan derivative using Bacillus sp. SUI-12: synthesis of a key intermediate of the melatonin receptor agonist TAK-375

The chiral indan derivative (S)-2 (2-[(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl-amine) was synthesized by enzyme-catalyzed asymmetric hydrolysis of the racemic acetamide 1 (N-[2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl]acetamide). The reaction was carried out using Bacillus sp. SUI-12 screened for the ability to hydrolyze 1 to give (S)-2 with high enantioselectivity. In a scaled-up experiment, a low reaction rate was observed. However, by changing the culture medium and the reaction conditions, it became possible to run the reaction to 40% conversion on a 10-g or more scale, obtaining (S)-2 at >;99% enantiomeric excess (ee). The (S)-2 obtained was available for the synthesis of the melatonin receptor agonist TAK-375 (N-[2-[(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]propanamide).     

DISLOCATION STRUCTURE AND NON-PROPORTIONAL HARDENING OF TYPE 304 STAINLESS STEEL

Abstract— This paper describes the microstructure of Type 304 stainless steel after cyclic loading at room temperature under tension-torsion non-proportional strain paths. The degree of cyclic non-proportional hardening is correlated with changes in the dislocation substructure. Dislocation cells, dislocation bundles, twins and stacking faults are all observed. The type of microstructure formed and resultant stress response is dependent on the degree of non-proportional loading and strain range. Cyclic stress range was uniquely correlated with mean cell size.     

Anti-Helicobacter pylori agents. 2. Structure activity relationships in a new series of 2-alkylguanidino-4-furylthiazoles

SAR for antimicrobial activity against H. pylori was investigated in a new series of 2-alkylguanidino-4-furylthiazoles. Of the compounds obtained, cyclohexylmethyl and ethoxyethyl derivatives were identified as a novel class of anti-H. pylori agents which possessed potent and selective antimicrobial activity against H. pylori. These compounds also showed gastric antisecretory activity.     

High oleic acid oil suppresses lung tumorigenesis in mice through the modulation of extracellular signal-regulated kinase cascade

This study was undertaken to estimate the effect of dietary high oleic acid oil (OA) on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in mice. Diet containing 10% oil was fed to mice through experimental periods. On day 30 after NNK injection (100 mg/kg body weight, i.p.), the treatment increased the level of prostaglandin E₂ (PGE₂) as well as proliferating cell nuclear antigen, a marker of cell proliferation in a high linoleic acid oil (LA)-fed group but not in an OA-fed group. The NNK treatment also induced the activation of an extracellular signal-regulated kinase (Erk) cascade (Erk, Mek and Raf-1) in an LA-fed group. On the other hand, OA feeding abolished the NNK-induced activation of the Erk cascade. In conjugation with these events, OA feeding reduced lung tumor incidence and tumor multiplicity (percentage of mice with tumors) in mice compared with LA feeding at the 20th experimental week. These results suggest that OA suppresses lung tumorigenesis and that this suppression is correlated with the inhibition of PGE₂ production and inactivation of the Erk cascade.     

CREEP-FATIGUE STUDIES UNDER A BIAXIAL STRESS STATE AT ELEVATED TEMPERATURE

In order to study creep-fatigue interactions under multiaxial stress states, both push-pull and reversed torsion low-cycle fatigue tests were carried out using an austenitic stainless steel, SUS 304, at 923 K in air. From the tests, it is concluded that the hold-times introduced at the peak strain reduce low-cycle fatigue lives in the push-pull mode, but in the torsional mode they were not so harmful. This difference in the hold-time effect is discussed from considerations of crack formation and propagation and the stress amplitude applied to the specimen. Both maximum principal strain range, Δε₁, and the von Mises' equivalent strain range, Δε_eq, provide a nearly adequate comparison base for the assessment of biaxial low-cycle fatigue lives in tests without strain hold-time but are inadequate for hold-time tests. An equivalent stress range, Δσ*, which includes the effect of the stress parallel to the fatigue crack and which was previously proposed by the authors for no hold-time tests, is applied to the hold-time tests in the biaxial stress state. It is found that Δσ* is a good parameter for the correlation of biaxial low-cycle fatigue data in both no hold-time and hold-time tests.