The Role of microRNAs in Development of Colitis-Associated Colorectal Cancer

Colorectal cancer (CRC) is the third most deadly cancer worldwide, and inflammatory bowel disease (IBD) is one of the critical factors in CRC carcinogenesis. IBD is responsible for an unphysiological and sustained chronic inflammation environment favoring the transformation. MicroRNAs (miRNAs) belong to a class of highly conserved short single-stranded segments (18–25 nucleotides) non-coding RNA and have been extensively discussed in both CRC and IBD. However, the role of miRNAs in the development of colitis-associated CRC (CAC) is less clear. The aim of this review is to summarize the major upregulated (miR-18a, miR-19a, miR-21, miR-31, miR-155 and miR-214) and downregulated (miR-124, miR-193a-3p and miR-139-5p) miRNAs in CAC, and their roles in genes’ expression modulation in chronic colonic-inflammation-induced carcinogenesis, including programmed cell-death pathways. These miRNAs dysregulation could be applied for early CAC diagnosis, to predict therapy efficacy and for precision treatment.     

Revamping SiO2 Spheres by Core–Shell Porosity Endowment to Construct a Mazelike Nanoreactor for Enhanced Catalysis in CO2 Hydrogenation to Methanol

Beyond the catalytic activity of nanocatalysts, the support with architectural design and explicit boundary could also promote the overall performance through improving the diffusion process, highlighting additional support for the morphology-dependent activity. To delineate this, herein, a novel mazelike-reactor framework, namely multi-voids mesoporous silica sphere (MVmSiO₂), is carved through a top-down approach by endowing core-shell porosity premade Stöber SiO₂ spheres. The precisely-engineered MVmSiO₂ with peripheral one-dimensional pores in the shell and interconnecting compartmented voids in the core region is simulated to prove combined hierarchical and structural superiority over its analogous counterparts. Supported with CuZn-based alloys, mazelike MVmSiO₂ nanoreactor experimentally demonstrated its expected workability in model gas-phase CO₂ hydrogenation reaction where enhanced CO₂ activity, good methanol yield, and more importantly, a prolonged stable performance are realized. While tuning the nanoreactor composition besides morphology optimization could further increase the catalytic performance, it is accentuated that the morphological architecture of support further boosts the reaction performance apart from comprehensive compositional optimization. In addition to the found morphological restraints and size-confinement effects imposed by MVmSiO₂, active sites of catalysts are also investigated by exploring the size difference of the confined CuZn alloy nanoparticles in CO₂ hydrogenation employing both in-situ experimental characterizations and density functional theory calculations.     

Study on Flow Behavior and Heat Exchange Characteristics of a Capillary Tube-Suction Line Heat Exchanger

The present research is to develop a homogenous mathematical model to simulate capillary tube-suction line heat exchanger (CT-SL HX) based on the fundamentals of conservations of mass, momentum and energy with comprehensive experimental result validations. The computer model is fully validated by 72 experimental data with error bands of ±15%, ±2°C and ±35% on the mass flow rate prediction, the suction pipe outlet temperature, and the heat exchange estimation respectively. The results suggest that the internal diameter of the capillary tube, and the heat-transfer length of the CT-SL HX have demonstrated an apparent impact on the capillary tube outlet conditions and heat transfer across the segment.     

A new sustainable hydrogen clean energy paradigm

We analyze the feasibility of a novel, hydrogen fuel cell electric generator to provide power with zero noise and emissions for myriad ground based applications. The hydrogen fuel cell electric generator utilizes a novel, scalable apparatus that safely generates hydrogen (H₂) on demand according to a novel method, using a controlled chemical reaction between water (H₂O) and sodium (Na) metal that yields hydrogen gas of sufficient purity for direct use in fuel cells without risk of contaminating sensitive catalysts. The sodium hydroxide (NaOH) byproduct of the hydrogen producing reaction, is collected within the apparatus for later reprocessing by electrolysis, to recover the Na reactant. The detailed analysis shows that the novel, hydrogen fuel cell electric generator will be capable of meeting the clean power requirements for residential and commercial buildings including single family homes and light commercial establishments under a wide range of geographic and climatic conditions.     

专业认证背景下铸造工艺课程设计教学改革的探讨

工程教育专业认证是保证、改进教育质量的重要途经,是以专业全体学生的学习结果为认证的主要目标。铸造工艺课程设计是综合性较强的专业核心课程,对于学生综合能力培养具有重要作用。本文基于对重庆大学材料成型及控制工程专业铸造工艺课程设计课程目标达成情况的分析,对课程教学的教学设计、组织形式、实施方法以及学业成绩评价等方面进行了改进,突出"以学生为中心"的工程应用水平和创新能力的培养。     

Optimal design of an integrated renewable-storage energy system in a mixed-use building

The rise of mixed-use buildings contributes to the sustainable development of cities but are still met with challenges in energy management due to the lack of energy efficiency and sustainability guidelines. The use of integrated renewable-storage energy systems is a more beneficial solution to this problem over individual solutions; however, most design studies only focused on single-type buildings. Thus, this study aims to optimally design an integrated energy system for mixed-use buildings using HOMER Grid. The objective is to minimize the net present costs, subject to capacity limits, energy balances, and operational constraints. Economic metrics were used to evaluate and compare the proposed system to the varying design cases such as business-as-usual, stand-alone renewable source, and stand-alone energy storage. The case study considered a mixed-use building in a tropical area, with a solar photovoltaic system as the renewable energy source and lithium-ion battery as the energy storage system technology. The results show that the integrated system is the most financially attractive design case. It has a levelized cost of electricity of 0.1384 US$ kWh⁻¹, which is significantly less than the 0.2580 US$ kWh⁻¹ baseline. The system also provides electricity cost savings of 294 698 US$ y⁻¹, excess electricity of 35 746 kWh, and carbon emission reduction of 550 tons annually for a mixed-use building with daily average consumption of 4557-kWh and 763-kW peak demand.     

多病床非典病房的气流分布研究

到2003年8月7日止，在全球34个国家和地区相继出现了严重急性呼吸系统综合症(SARS或者非典)，其中，共报告有8422例疑似案例，916例死亡案例。2002年11月到2003年6月间的非典流行中，医院医护人员受感染情况最为严重，世界范围内20％的感染群体为医护人员，香港地区22％的确诊案例为医护人员。因此，为减少交叉感染，加强有关工程控制，特别是在非典病房里进行通风设计是非常必要的。本文总结了非典病房气流分布的最新研究。这项研究由非典特工队于2003年4～7月间完成。非典特工队是由香港工程师协会组织，来自7个专家协会的工程师组成的研究小组。在对香港治疗非典医院的现有空调系统进行了解后，非典特工队首先运用计算流体力学模拟确定了在6个床位的病房里减少交叉感染和改善污染物稀释的通风设计；接着，对新设计在香港大学屋宇设备实验室里的全尺寸非典病房里进行了测试。测试表明，新设计方案在这个接近现实的全尺寸非典病房里运行良好。采用床头回风口回风设计可有效地对病人产生的含病毒颗粒进行局部捕获。根据这项研究，作者提出了原则性的设计建议。2003年里，香港政府和医院管理局医院采纳了非典特工队提出的设计基本原理建造了1200多个床位的可用于非典治疗的新病房。另外，气流分布是复杂的紊流过程，送风格栅结构如导流器或散流器的微小改动以及送风参数如风速、温度和风向的微小变化都会引起气流的改变。适当的设计对于减少病人间、病人与医护人员之间的交叉感染以及有效稀释和排除含病菌颗粒都是至关重要的。     

FixMyStreet Brussels: Socio-Demographic Inequality in Crowdsourced Civic Participation

FixMyStreet (FMS) is a web-based civic participation platform that allows inhabitants to report environmental defects like potholes and damaged pavements to the government. In this paper, we examine the use of FMS in Brussels, the capital city of Belgium. Analyzing a total of 30,041 reports since its inception in 2013, we demonstrate how civic participation on FMS varies between the ethnically diverse districts in Brussels. We compare FMS use to a range of sociodemographic indicators derived from official city statistics as well as geotagged social media data from Twitter. Our statistical analysis revealed several significant differences between the districts that suggested that crowdsourced civic participation platforms tend to marginalize low-income and ethnically diverse communities. In this respect, our findings provide timely evidence to inform the design of more inclusive crowdsourced, civic participation platforms in the future.